Integrative multi-omics and machine learning reveal glycolysis-related biomarkers driving vascular remodeling in pulmonary arterial hypertension [0.03%]
整合多组学和机器学习发现驱动肺动脉高压血管重塑的糖酵解相关生物标志物
Hongyi Tian,Zihua Liu,Junrui He et al.
Hongyi Tian et al.
Metabolic reprogramming toward aerobic glycolysis, a phenomenon analogous to the Warburg effect, is increasingly recognized as a hallmark of pulmonary arterial hypertension (PAH). However, how glycolytic activation orchestrates pulmonary va...
Netrin-1 protects against doxorubicin-induced cardiotoxicity by suppressing ferroptosis via the UNC5B-LKB1/CaMKKβ-AMPK-NRF2 axis [0.03%]
NETRIN-1通过UNC5B-LKB1/CaMKKβ-AMPK-NRF2轴抑制铁死亡来预防多柔比星致心脏毒性
Wei Lu,Haibo Wu,Yanqing Wang et al.
Wei Lu et al.
Doxorubicin (DOX)-induced cardiotoxicity is strongly associated with ferroptosis and oxidative stress, yet the endogenous protective mechanisms remain incompletely understood. This study aimed to determine whether Netrin-1 protects against ...
Mechanistic insights into mesenchymal stem cell therapy for cognitive impairments in Alzheimer's disease models: a systematic review and meta-analysis [0.03%]
间充质干细胞治疗阿尔茨海默病模型认知障碍的机制研究系统评价和元分析
Haniyeh Kariminejad-Farsangi,Hadis Kariminejad-Farsangi,Yousof Mir et al.
Haniyeh Kariminejad-Farsangi et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatment options that primarily offer symptomatic relief. Mesenchymal stem cells (MSCs) have shown promise in preclinical studies due to their neuroprotectiv...
Single-cell transcriptomics reveals glycolytic heterogeneity and identifies STC2 as a key regulator of metabolic reprogramming in osteosarcoma [0.03%]
单细胞转录组揭示了骨肉瘤中的糖酵解异质性并鉴定出STC2是代谢重编程的关键调节因子
Xu Hu,Qinfen Wang,Shishui Lin
Xu Hu
Osteosarcoma (OS) exhibits profound metabolic reprogramming, yet the specific cellular subpopulations and regulatory networks governing glycolysis within the tumor microenvironment remain elusive. We integrated single-cell RNA sequencing (s...
UCHL1-mediated deubiquitination of GLOD4 regulates mitochondrial homeostasis and PTC malignant progression via GLO1 [0.03%]
UCHL1介导的GLOD4去泛素化通过GLO1调节线粒体稳态和PTC恶性进展
Lei Cai,Li-Yuan Qian,Wei Wu et al.
Lei Cai et al.
Papillary thyroid carcinoma (PTC) is prone to metastasis, and patients with metastatic PTC have a poor prognosis. This study aimed to investigate the function of GLOD4 in PTC. Cancerous and paracancerous tissues were collected from patients...
N-glycosylation of ERLIN2 promotes hepatocellular carcinoma progression by enhancing CCNB1 stability [0.03%]
ERLIN2的N-糖基化通过增强CCNB1稳定性促进肝癌进展
Sijie Li,Huanhuan Huang,Jiahui Feng et al.
Sijie Li et al.
Hepatocellular carcinoma (HCC) ranks among the most lethal cancers, and its dismal prognosis underscores the urgent need to elucidate the underlying carcinogenic mechanisms. Endoplasmic reticulum lipid rafts associated protein 2 (ERLIN2), a...
Flavonoids as functional food-derived modulators of the gut microbiota-NF-κB axis in metabolic dysfunction-associated steatotic liver disease [0.03%]
黄酮类化合物作为功能性食品来源的调节肠道微生物群-NF-κB轴在与代谢功能异常相关的肝脂肪变性疾病中的作用
Lunasmrita Saikia,Partha Pratim Dutta,Douglas Law et al.
Lunasmrita Saikia et al.
Metabolically Dysfunctional-Associated Steatotic Liver Disease (MASLD) is increasingly recognised as a gut-liver axis disorder driven by sustained activation of pro-inflammatory signalling networks, particularly the NF-κB pathway. Flavonoi...
Chronic bisphenol A exposure activates the cGAS-STING-NLRP3 axis driving persistent hippocampal neuroinflammation and cognitive impairment [0.03%]
慢性双酚A暴露激活cGAS-STING-NLRP3轴驱动海马体持续性神经炎症和认知障碍
Veena V Tom,Sumit Mallick,Athira Sasidharan et al.
Veena V Tom et al.
Bisphenol A (BPA), a main component of polycarbonate plastics and epoxy resins, has been reported to cause chronic neuroinflammation and cognitive impairment in animal models. However, the precise molecular mechanisms of BPA-induced chronic...
Renoprotective effects of vitamin D and thymoquinone, alone and in combination, in a rat co-treatment model of gentamicin-induced acute kidney injury [0.03%]
维生素D和藤黄酸联合用及其单独使用对庆大霉素致急性肾损伤的保护作用： rats 中模型的研究
Bassem Refaat,Ahmed M El-Sebaey,Anmar Khan et al.
Bassem Refaat et al.
To investigate the prophylactic (co-treatment) effects of vitamin D (VD), thymoquinone (TQ), and their combination against gentamicin (GM)-induced acute kidney injury (AKI). Forty male Wistar rats were divided into five groups: negative con...
Inhibition of the mitochondrial pyruvate carrier attenuates the integrated stress response activation in a cellular model of Huntington's disease [0.03%]
抑制线粒体丙酮酸载体可减轻亨廷顿舞蹈病细胞模型中综合应激反应的激活
Ângela Oliveira,Liliana M Almeida,Jorge M A Oliveira et al.
Ângela Oliveira et al.
Mitochondrial pyruvate carrier (MPC) inhibition was found protective in models of neurodegenerative diseases, such as Alzheimer's and Parkinson's. However, little is known about MPC as a potential therapeutic target in Huntington's disease ...