Retraction Note: Knockdown of TRAP1 promotes cisplatin-induced apoptosis by promoting the ROS-dependent mitochondrial dysfunction in lung cancer cells [0.03%]
撤回 notice: 抑制 TRAP1 通过促进 ROS 依赖性线粒体功能障碍促进肺癌细胞顺铂诱导的凋亡
Xiaowei Zhang,Yu Dong,Miao Gao et al.
Xiaowei Zhang et al.
MELK inhibits cuproptosis in diffuse large B-cell lymphoma cells via the PI3K/mTOR/S6K-DLAT signaling axis [0.03%]
MELK通过PI3K/mTOR/S6K-DLAT信号轴抑制弥漫性大B细胞淋巴瘤细胞的铜死亡
Xiaoxiao Wang,Chenchen Wang,Chen Wang et al.
Xiaoxiao Wang et al.
With a wide range of genetic characteristics and metabolic requirements, diffuse large B-cell lymphoma (DLBCL) is an extremely complex cancer. Although maternal embryonic leucine zipper kinase (MELK) has been linked to the development of tu...
Anemoside B4 inhibits mitochondrial dysfunction-related mitophagy in asthma by regulating KAT2B/IRF3 axis [0.03%]
风药B4通过调节KAT2B/IRF3轴抑制哮喘相关的线粒体功能障碍相关自噬
Hao Tang,Ping Li,Mingxia Shang et al.
Hao Tang et al.
Asthma is a classical inflammation-related disease, and its pathogenesis is closely associated with mitochondrial dysfunction and mitophagy. Although Anemoside B4 (AmB4) exhibits anti‑inflammatory properties in various diseases, its role i...
A spatial transit-retention axis reveals adaptive immune organisation in psoriatic disease [0.03%]
空间交通-保留轴揭示了银屑病适应性免疫的组织方式
Caio Santos Bonilha
Caio Santos Bonilha
Spatial organisation of immune cells reflects a balance between tissue anchoring and migratory compatibility, yet how this balance is structured within inflammatory skin disease remains poorly understood. Spatial transcriptomic analyses def...
The role of mitochondrial regulation in macrophage polarization by Ganoderma lucidum polysaccharide for the treatment of colitis-associated colorectal cancer [0.03%]
亮菌多糖通过线粒体调节极化巨噬细胞治疗结肠炎相关性结直肠癌的作用机制研究
Zhaorong Ouyang,Wanqiu Ye,Guolei Wen et al.
Zhaorong Ouyang et al.
Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Ganoderma lucidum polysaccharide (GLP) has shown significant potential in regulating macrophage polarization and treating CRC. However, the role of mitochondrial re...
Nobiletin attenuates self-renewal in cervical cancer cells and spheres through miR-342-3p upregulation and FOXM1 downregulation [0.03%]
诺贝利丁通过上调miR-342-3p和下调FOXM1来减弱宫颈癌细胞和类器官的自我更新能力
Lun Huang,Weifeng Feng,Wenlan Long et al.
Lun Huang et al.
Cervical cancer (CC) cells exhibiting self-renewal properties are regarded as the primary drivers of recurrence. Nobiletin (NOB), a polymethoxy flavonoid derived from citrus, demonstrates effective suppression of cancer stem cell characteri...
Olaparib alleviates diclofenac-induced toxicity in HepG2 cells via modulation of oxidative stress and mitochondrial functions [0.03%]
奥拉帕尼通过调节氧化应激和线粒体功能缓解扑炎痛诱导的肝癌细胞毒性
Mohamed Maki,Viola B Vantus,Balazs Koszegi et al.
Mohamed Maki et al.
Non-steroidal anti-inflammatory agents are widely used for their analgesic, anti-inflammatory, and antipyretic effects, and a prominent representative of the drug family, diclofenac has recently been proposed for cancer therapy. However, ov...
NEFL⁺NEFM⁺ myeloid-reprogrammed cells promote ccRCC progression through CX3CL1-CX3CR1-mediated Tregs chemotaxis [0.03%]
NEFL⁺NEFM⁺髓系重编程细胞通过CX3CL1-CX3CR1介导的Treg募集促进透明细胞肾细胞癌进展
Shuran Zi,Zhenduo Yu,Zhengrunhong Zhao et al.
Shuran Zi et al.
Tumor-associated myeloid cells (TAMCs) fuel immune evasion and progression, yet their roles in clear cell renal cell carcinoma (ccRCC) remain unclear. Single-cell transcriptomic analyses have suggested the emergence of myeloid cells express...
Unveiling muscle fatigue: identifying key gene biomarkers and therapeutic targets [0.03%]
揭秘肌肉疲劳：识别关键基因生物标志物和治疗靶点
Yifei Zhang,Zehan Zhang,Xiaoyao Chen et al.
Yifei Zhang et al.
Muscle fatigue, a potential risk factor for athlete injuries, lacks specific therapeutic targets and diagnostic biomarkers. This study aimed to identify biomarkers or targets for muscle fatigue to develop new diagnostic and treatment approa...
Deciphering the anticancer potential of an entomopathogenic fungus, Cordyceps militaris in Dalton's Lymphoma transplanted murine model: a multidimensional approach involving computational methods and in vivo validation [0.03%]
采用计算方法和体内验证相结合的多维度方法解码达尔顿淋巴瘤移植小鼠模型中昆虫病原真菌虫草素的抗癌潜力
Diksha Dutta,Akalesh Kumar Verma,Namram Sushindrajit Singh et al.
Diksha Dutta et al.
Cordyceps militaris, a medicinal mushroom in traditional Chinese medicine, emerged as a promising source of bioactive compounds, exhibiting potent antioxidant, anti-inflammatory, anticancer, antiviral and immunomodulatory properties. Despit...