Deciphering the interplay between cuproptosis and mitochondrial energy metabolism in thyroid cancer: a multi-omics study for molecular subtyping, prognosis, and tumor microenvironment characterization [0.03%]
铜死亡与甲状腺癌线粒体能量代谢相互作用的解析：分子分型、预后和肿瘤微环境表征的多组学研究
Hongbo Le,Yang Wu,Nan Wu et al.
Hongbo Le et al.
Thyroid cancer (THCA) exhibits substantial heterogeneity in clinical outcomes. The interaction between cuproptosis, a novel copper-dependent form of cell death, and mitochondrial energy metabolism, a key regulator of cellular bioenergetics,...
Effects of LATS1/2 kinases inhibition on lung epithelial cells in a regeneration model [0.03%]
LATS1/2激酶抑制对再生模型中肺上皮细胞的影响
Irina A Govorova,Yulia A Novikova,Oksana I Sutyagina et al.
Irina A Govorova et al.
Research focused on studying Hippo signaling up- and downregulation in a model of mouse lung cell regeneration. The cell-specific role of the activation and inhibition of Hippo signaling is demonstrated at the cellular level within the cont...
COLEC12 promotes pancreatic cancer progression via the activation of the TGF-β signaling pathway [0.03%]
COLEC12通过激活TGF-β信号通路促进胰腺癌进展
Xin Feng,Jian Xu,Qingqing Yang et al.
Xin Feng et al.
Collectin Subfamily Member 12 (COLEC12), a C-type lectin family member with collagen-like and carbohydrate recognition domains, remains poorly characterized in pancreatic cancer (PC). COLEC12 expression was analyzed by bioinformatics and im...
Therapeutic effects of alprostadil on CCl4-induced hepatic fibrosis in rats and investigation of its molecular mechanisms [0.03%]
前列腺素E1类似物艾普拉唑特对四氯化碳所致大鼠肝纤维化的治疗作用及分子机制探讨
Ziqing Shen,Yanfen Zhang,Rongwei Zhao et al.
Ziqing Shen et al.
Hepatic fibrosis (HF) is driven by hepatic stellate cell (HSC) activation. Although cyclic adenosine monophosphate (cAMP) is a key antifibrotic signal, whether pharmacological cAMP elevation acts through protein kinase A (PKA) or exchange p...
Olfactory bulb 6-OHDA neurotoxicity as a model of early cortical dysfunction [0.03%]
嗅球6-OHDA神经毒性作为皮质早期功能障碍模型的方法
Edson Fiorenza-Neto,Bruna B Gattiboni,Karin Almeida et al.
Edson Fiorenza-Neto et al.
The olfactory bulb (OB) is one of the earliest brain regions affected in neurodegenerative diseases such as Parkinson's disease (PD). Its high metabolic rate, dopaminergic modulation, and connectivity with the cortical and limbic regions ma...
Serum miR-197-3p as a diagnostic and prognostic biomarker in traumatic brain injury: involvement in MyD88-dependent microglial polarization [0.03%]
脑创伤后血清miR-197-3p作为诊断和预后生物标志物的作用及对MyD88依赖性的小胶质细胞极化的影响
Yan Xu,Yuan Tian,Liping Wang et al.
Yan Xu et al.
The prognosis and management of severe traumatic brain injury (TBI) remain significant clinical challenges. The role of serum miR-197-3p in TBI remains unclear. This study aimed to explore its potential as a diagnostic and prognostic biomar...
Alginate oligosaccharides promote wound healing and induce macrophage M2 polarisation by activating the PI3K/AKT1 signalling pathway [0.03%]
alginate寡糖促进伤口愈合并诱导巨噬细胞M2极化通过激活PI3K / AKT1信号通路
Lei Liu,Bohan Pan,Zihan Tao et al.
Lei Liu et al.
The objective of this study was to investigate the effects of alginate oligosaccharides on wound cell proliferation, migration, apoptosis, macrophage polarisation, and wound healing. The results of the Cell Counting Kit-8, Transwell method,...
Dysregulated KIF2A correlates with p53 expression pattern in breast cancer [0.03%]
微管相关蛋白KIF2A在乳腺癌中的表达失调及与p53表达模式的相关性研究
Yun Hao,Si-Qin Ma,Ting Xu et al.
Yun Hao et al.
Kinesin family member 2A (KIF2A) and p53 play crucial roles in tumor development and progression. However, their correlation in breast cancer remains unclear. Immunohistochemistry (IHC) was performed on 357 breast cancer specimens to invest...
Enhanced ITGA3 expression induced by helicobacter pylori infection facilitates gastric cancer progression via NF-κB and Smad4 [0.03%]
幽门螺旋杆菌通过NF-κB和Smad4促进ITGA3表达增强从而促进胃癌进展
Yuanxin Xing,Yan Chu,Wenshuai Zhu et al.
Yuanxin Xing et al.
Helicobacter pylori (H. pylori) infection is a key risk factor in the onset and progression of gastric cancer (GC). The integrin subunit alpha 3 (ITGA3) is frequently upregulated in various malignancies and may influence cell proliferation ...
Editorial Expression of Concern: Chloride channels and mast cell function: pioneering new frontiers in IBD therapy [0.03%]
社论关注：氯通道和肥大细胞功能：在IBD治疗方面开拓新领域
Ahmed M Aljameeli,Bader Alsuwayt,Deepak Bharati et al.
Ahmed M Aljameeli et al.