Amelioration of doxorubicin-mediated nephrotoxicity through antioxidant and anti-apoptotic mechanisms of 5,4'-dihydroxy-6,8-dimethoxy-7-O-rhamnosylflavone [0.03%]
5,4'-二羟基-6,8-二甲氧基-7-O-鼠李糖 flavone通过抗氧化和抗凋亡机制改善多柔比星引起的肾毒性
Peramaiyan Rajendran,Abdullah Alzahrani,Ramya Sekar et al.
Peramaiyan Rajendran et al.
Doxorubicin (DOX), a cornerstone chemotherapeutic, induces dose-limiting nephrotoxicity through NOX-4-mediated oxidative stress, inflammatory signalling, and apoptosis, thereby compromising its long-term clinical utility. This study investi...
Optimization of RNP-CRISPR for high-efficiency gene editing in mouse intestinal organoids [0.03%]
用于小鼠肠类器官高效基因编辑的RNP-CRISPR优化方法
Xiya Cao,Youyuan He,Haozhe Guo et al.
Xiya Cao et al.
Mouse intestinal organoids are ideal models for investigating intestinal development and diseases. The full potential of these models hinges on the ability to precisely engineer their genome, yet traditional methods for CRISPR-based editing...
Current progress in pathway-targeted therapeutics for Alzheimer's disease: mechanistic insights and windows of opportunity [0.03%]
阿尔茨海默病通路靶向治疗的最新进展：机制见解和时机窗口
Habab Ali Ahmad,Mahnoor Zafar,Tooba Khan et al.
Habab Ali Ahmad et al.
Association between neutrophil percentage-to-albumin ratio and all-cause mortality in patients post-cardiac surgery: a retrospective cohort study [0.03%]
中性粒细胞百分比-白蛋白比率与心脏手术后全因死亡率之间的关联：一项基于回顾性队列的研究
Shu-Bin Lv,Qiong Lv,Di Luo
Shu-Bin Lv
The pivotal role of mitochondria in the pathogenesis and treatment of liver failure: a comprehensive review [0.03%]
线粒体在肝衰竭发病机制和治疗中的关键作用：全面综述
Qing Peng,Liyuan Hao,Shenghao Li et al.
Qing Peng et al.
MALAT1 promotes acetaminophen-induced hepatocyte pyroptosis by stabilizing Rac1 through its interaction with MTDH and the hepatoprotective role of muniziqi saifula [0.03%]
MALAT1通过与MTDH的相互作用稳定Rac1促进对乙酰氨基酚致肝细胞焦亡及 Muniziquisaifula 的保护作用
Yilifanjiang Kuerban,Aman Gul,Zulipikaer Wusiman et al.
Yilifanjiang Kuerban et al.
Huifang Tang,Qian Gao,Shu Xie
Huifang Tang
Liver-specific SLC13A3 modulation alleviates MASLD by regulating NAD+ metabolism [0.03%]
通过调节NAD+代谢特异性调控肝脏SLC13A3可缓解MASLD
Jiangxia Du,Minhui Shen,Yuan Mu et al.
Jiangxia Du et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a prevalent chronic liver disorder with complex pathogenesis and limited therapeutic options. Here, we identif...
Gomisin A and metformin co-treatment attenuates diabetic nephropathy and cardiovascular dysfunction by modulating the AGE/RAGE pathway in a diabetic rat model [0.03%]
gomisin A联合二甲双胍通过调节糖尿病大鼠模型中的AGE/RAGE信号通路缓解糖尿病肾病和心血管功能障碍
S P Ramya Ranjan Nayak,Pratik Pohokar,M Valan Arasu et al.
S P Ramya Ranjan Nayak et al.
Diabetic nephropathy (DN) is a severe complication of type 2 diabetes mellitus (T2DM) that is frequently accompanied by cardiovascular disease (CVD) and chronic kidney disease (CKD). The current therapeutic options for DN and CVD are limite...
MiRNA based liquid biopsy for castration-resistant prostate cancer diagnostics [0.03%]
基于miRNA的液体活检在去势抵抗性前列腺癌诊断中的应用研究
Maria Y Konoshenko,Milena M Saitkulova,Ekaterina V Shutko et al.
Maria Y Konoshenko et al.