Development and classification of RNA aptamers for therapeutic purposes: an updated review with emphasis on cancer [0.03%]
用于治疗目的的RNA适配子的发展和分类：最新综述，并强调癌症方面的内容
Mahtab Razlansari,Somayeh Jafarinejad,Abbas Rahdar et al.
Mahtab Razlansari et al.
Today, RNA aptamers are being considered promising theranostic tools against a wide variety of disorders. RNA aptamers can fold into complex shapes and bind to diverse nanostructures, macromolecules, cells, and viruses. It is possible to is...
CEP55 predicts the poor prognosis and promotes tumorigenesis in endometrial cancer by regulating the Foxo1 signaling [0.03%]
CEP55通过调节Foxo1信号促进子宫内膜癌肿瘤发生并预示不良预后
Xinping Zhang,Quanxiao Xu,Enping Li et al.
Xinping Zhang et al.
Endometrial cancer is a common gynecologic cancer, which is relevant to many differentially expressed genes. Centrosomal protein 55 (CEP55) was proved to be aberrantly expressed in several cancers. However, the function of CEP55 in endometr...
Baicalein sensitizes triple negative breast cancer MDA-MB-231 cells to doxorubicin via autophagy-mediated down-regulation of CDK1 [0.03%]
黄芩素通过自噬介导下调CDK1使三阴性乳腺癌MDA_MB_231细胞对多柔比星敏感
Fang Hua,Yi-Yi Xiao,Xin-Hui Qu et al.
Fang Hua et al.
Triple negative breast cancer (TNBC) is a kind of refractory cancer with poor response to conventional chemotherapy. Recently, the combination of baicalein and doxorubicin was reported to exert a synergistic antitumor effect on breast cance...
Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise [0.03%]
多发性硬化症患者中的呼吸系统问题作为SARS-CoV-2感染期间的风险因素：运动的潜在作用
Omid Razi,Ana Maria Teixeira,Bakhtyar Tartibian et al.
Omid Razi et al.
Coronavirus disease-2019 (COVID-19) is associated with cytokine storm and is characterized by acute respiratory distress syndrome (ARDS) and pneumonia problems. The respiratory system is a place of inappropriate activation of the immune sys...
Pooled evidence from preclinical and clinical studies for stem cell-based therapy in ARDS and COVID-19 [0.03%]
针对ARDS和COVID-19基于干细胞治疗的临床前和临床研究的汇集证据
Dhanashree Murugan,Loganathan Rangasamy
Dhanashree Murugan
COVID-19 has severely devastated many lives across the globe. It has been speculated that stem cell-based therapy for COVID-19 treatment could be able to subsidize the effects. In preclinical and clinical studies, stem cell-based therapy ha...
Luteoloside pretreatment attenuates anoxia-induced damage in cardiomyocytes by regulating autophagy mediated by 14-3-3η and the AMPKα-mTOR/ULK1 pathway [0.03%]
芹菜素通过调节14-3-3η和AMPKα-mTOR/ULK1通路介导的自噬来减轻心肌细胞缺氧引起的损伤
Tianhong Hu,Lin Wen,Liang Wang et al.
Tianhong Hu et al.
The relation between ischemia and heart failure is well demonstrated, and several studies suggested that realizing the physiological role of autophagy will be of great importance. Luteoloside (Lut) is one of the main components of Lonicera ...
Correction: Protein kinase CK2 - diverse roles in cancer cell biology and therapeutic promise [0.03%]
纠正：蛋白激酶CK2 - 在癌症细胞生物学中的多种作用及治疗前景
Janeen H Trembley,Betsy T Kren,Muhammad Afzal et al.
Janeen H Trembley et al.
Published Erratum
Molecular and cellular biochemistry. 2023 Jul;478(7):1659. DOI:10.1007/s11010-022-04608-9 2023
The role of Nod-like receptor protein 3 inflammasome activated by ion channels in multiple diseases [0.03%]
离子通道激活的NOD样受体蛋白3炎症小体在多种疾病中的作用
Xiaolin Xu,Xianli Wu,Gengyu Yue et al.
Xiaolin Xu et al.
The inflammasome is a multimeric protein complex located in the cytoplasm that is activated by many factors and subsequently promotes the release of proinflammatory factors such as interleukin (IL)-1β and IL-18, resulting in a series of in...
The downstream PPARγ target LRRC1 participates in early stage adipocytic differentiation [0.03%]
下游的PPARγ靶标LRRC1参与早期脂肪细胞分化过程
Xinping Wang,Jianyun Liu,Ting Wang et al.
Xinping Wang et al.
LRRC1 is a regulator of cellular polarity that is expressed at high levels in a range of tumor tissue types. Here, we conducted an analysis of the previously unexplored role of LRRC1 as a component of the adipogenic differentiation network....
Fibroblasts and mouse breast cancer cells can form cellular aggregates in improved soft agar culture medium [0.03%]
成纤维细胞和小鼠乳腺癌细胞可以在改良的软琼脂培养基中形成细胞团
Xiangnan Zhang,Shuo Liang,Enze Wang et al.
Xiangnan Zhang et al.
We aimed to build cellular aggregates of TS/A and normal fibroblasts (LX-2) or CAFs (ME-iLX-2), verifying the value of this model in the screening of anticancer drugs and demonstrating the effect of CD44 on aggregate formation. We improved ...