The factors between BMI and diabetic nephropathy and protective role of the FGF21-SIRT1 axis in diabetic nephropathy [0.03%]
BMI与糖尿病肾病之间的因素及FGF21-SIRT1轴在糖尿病肾病中的保护作用
Chao Liu,Qiu Zhang,Yi Zhang
Chao Liu
Obesity and diabetic nephropathy (DN) represent escalating global health burdens. Glomerular mesangial cell (MC) injury, driven by lipotoxicity from free fatty acids like palmitic acid (PA), is central to DN pathogenesis. Fibroblast growth ...
Naringenin inhibits endothelial-mesenchymal transition and alleviates myocardial fibrosis in rats by regulating the AKT/GSK3β/β-catenin pathway [0.03%]
柚皮素通过调节AKT/GSK3β/β-链蛋白信号通路抑制内皮间质转化并缓解大鼠心肌纤维化
Kai Huang,Chongyu Shao,Huifen Zhou et al.
Kai Huang et al.
Endothelial-mesenchymal transition (EndMT) is increasingly recognized as a critical factor contributing to myocardial fibrosis, which ultimately leads to cardiac dysfunction. Naringenin (NAR), a major flavonoid derived from citrus fruits, e...
P2Y12-AMPKα2 signaling contributes to cardiomyocyte senescence in doxorubicin-induced heart failure [0.03%]
氯吡格雷-AMPKα2信号转导参与阿霉素致心力衰竭中心肌细胞衰老
Qianqian Niu,Huidan Wang,Mengyao Zhao et al.
Qianqian Niu et al.
Doxorubicin (DOX)-induced cardiotoxicity is closely associated with oxidative stress, DNA damage, and senescence-related cardiac injury. This study evaluated the protective effects of Floralozone against DOX-induced cardiac injury and explo...
Synthesis and multilevel evaluation of benzimidazole-based anticancer compounds: DNA/serum albumin interaction, and in-depth theoretical insights [0.03%]
基于苯并咪唑的抗癌症化合物的合成及多级评价：DNA/血清白蛋白相互作用及深入理论见解
Sevgi Kundu,Senem Akkoc,Yalçın Erzurumlu et al.
Sevgi Kundu et al.
Within the scope of this investigation, two novel compounds (3a and 3b) were designed and synthesized in two steps. Compounds 3a and 3b were tested utilizing the MTT study to evaluate their in vitro cytotoxic activity against healthy human ...
Hijacking the cytoskeleton: association of HCV polymerase with α/β-tubulin and its potential relation to the viral replication and cell proliferation [0.03%]
寨卡病毒利用宿主细胞骨架的机制及其与登革病毒的比较研究
Ahmed A Ali
Ahmed A Ali
Hepatitis C virus (HCV) manipulates host cellular pathways to create favourable conditions that support its replication and persistence. Identifying virus-host interactions helps to prevent disease progression and supports the development o...
RBM15 promotes hyperglycemia-induced retinal endothelial cell injury by regulating FOXO3 stability via m6A modification [0.03%]
RBM15通过m６A修饰调控FOXO３稳定性促进高糖诱导的视网膜内皮细胞损伤
Yang Yu,Yuqing Ren,Su Dong et al.
Yang Yu et al.
Diabetic retinopathy (DR), a common microvascular complication of diabetes mellitus, is a leading cause of vision loss among working-age adults. Although N6-methyladenosine (m6A), a prevalent post-transcriptional mRNA modification, is emerg...
Network pharmacology and experimental verification to explore the therapeutic mechanism of esketamine in postoperative cognitive dysfunction [0.03%]
基于网络药理学和实验验证的氯胺酮术后认知功能障碍治疗机制研究
Yifei Zhan,Shuai Liu,Yan Li et al.
Yifei Zhan et al.
Postoperative Cognitive Dysfunction (POCD) is one of the most common perioperative complications, which has already become a significant challenge for postoperative patient management. Esketamine has demonstrated promising therapeutic poten...
Pharmacological effect of rhCC16 on COPD: anti-senescence via the PI3K-AKT-mTOR pathway [0.03%]
人rhCC16蛋白的药理学效应及其对COPD治疗中抗衰老的作用机制研究
Rui Gao,Shuo Wu,Chu-Lin Zhang et al.
Rui Gao et al.
Cigarette smoke (CS) is a major risk factor for chronic obstructive pulmonary disease (COPD). CS exposure disrupts the oxidant‑antioxidant balance in the lungs, which may contribute to cellular senescence - a process implicated in the init...
Correction to: Puerarin alleviates myocardial ischemia-reperfusion injury by enhancing FUNDC1-mediated mitophagy [0.03%]
Correction to：大豆异黄酮朴克素通过增强FUNDC1介导的线粒体自噬来缓解心肌缺血再灌注损伤
Na Feng,Anhua Zhang,Lingling Yao et al.
Na Feng et al.
Published Erratum
Molecular and cellular biochemistry. 2026 Jun 19. DOI:10.1007/s11010-026-05596-w 2026
CCL3 promotes oxaliplatin resistance in gastric cancer via CCR5-mediated tumor cell survival and macrophage M2 polarization [0.03%]
CCL3通过CCR5介导的肿瘤细胞存活和巨噬细胞M2极化促进胃癌耐药性
Xun Cheng,Zhe Qin
Xun Cheng
Although oxaliplatin (Oxa)-based chemotherapy is a standard treatment for gastric cancer (GC), its clinical efficacy is frequently limited by the development of Oxa resistance. Chemokine CCL3 is linked to tumor growth, which can result in t...