F Jauregui-Huerta,Y Ruvalcaba-Delgadillo,R Gonzalez-Castañeda et al.
F Jauregui-Huerta et al.
A growing body of evidence suggests that glial cells are involved in practically all aspects of neural function. Glial cells regulate the homeostasis of the brain, influence the development of the nervous system, modulate synaptic activity,...
The Oncogenic Potential of Mesenchymal Stem Cells in the Treatment of Cancer: Directions for Future Research [0.03%]
有关癌症治疗中间质干细胞致癌潜能的研究方向
Eric N Momin,Guillermo Vela,Hasan A Zaidi et al.
Eric N Momin et al.
Mesenchymal stem cells (MSCs) represent a promising new approach to the treatment of several diseases that are associated with dismal outcomes. These include myocardial damage, graft versus host disease, and possibly cancer. Although the po...
Immunobiology of herpes simplex virus and cytomegalovirus infections of the fetus and newborn [0.03%]
HSV和CMV对胎儿和新生儿的免疫生物学影响
William J Muller,Cheryl A Jones,David M Koelle
William J Muller
Immunologic "immaturity" is often blamed for the increased susceptibility of newborn humans to infection, but the precise mechanisms and details of immunologic development remain somewhat obscure. Herpes simplex virus (HSV) and cytomegalovi...
Peripheral Tolerization of Effector and Memory T Cells: Implications for Autoimmunity and Tumor-Immunity [0.03%]
效应和记忆T细胞的外周耐受：对自身免疫和肿瘤免疫的意义
Adam J Adler
Adam J Adler
Due to the random generation of T cell antigen receptors, a large fraction of developing T cells have the potential to recognize self-determinants. To prevent this self-reactive T cell repertoire from mediating autoimmunity, the immune syst...
Leptin and Inflammation [0.03%]
瘦素与炎症关系研究进展
Noriko Iikuni,Queenie Lai Kwan Lam,Liwei Lu et al.
Noriko Iikuni et al.
The past few years of research on leptin have provided important information on the link between metabolism and immune homeostasis. Adipocytes influence not only the endocrine system but also the immune response through several cytokine-lik...
The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous System [0.03%]
鼠冠状病毒感染中枢神经系统的炎症和脱髓鞘的生物学：持续性感染
Martin P Hosking,Thomas E Lane
Martin P Hosking
Multiple Sclerosis (MS) is an immune-mediated demyelinating disease of humans. Although causes of MS are enigmatic, underlying elements contributing to disease development include both genetic and environmental factors. Recent epidemiologic...
Beyond Stressed Self: Evidence for NKG2D Ligand Expression on Healthy Cells [0.03%]
超越压力自我：健康细胞表达NKG2D配体的证据
Robert A Eagle,Insiya Jafferji,Alexander D Barrow
Robert A Eagle
The activity of cytotoxic lymphocytes is regulated by the opposing function of stimulatory and inhibitory cell surface receptors. According to the now classical model of Natural Killer (NK) cell activity, the ligands for inhibitory receptor...
Heterogeneity in the CD4 T Cell Compartment and the Variability of Neonatal Immune Responsiveness [0.03%]
CD4T细胞亚群的异质性与新生儿免疫反应的可变性
Becky Adkins
Becky Adkins
Over the past decade, it has become clear that T cell immune responses in both murine and human neonates are very heterogeneous, running the gamut from poor or deviant responsiveness to mature, adult-like inflammatory function. How this var...
Regulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversity and Consequences for Immunity [0.03%]
革兰氏阳性菌对凋亡的调控：机制多样性及其对免疫的影响
Glen C Ulett,Elisabeth E Adderson
Glen C Ulett
Apoptosis, or programmed cell death (PCD), is an important physiological mechanism, through which the human immune system regulates homeostasis and responds to diverse forms of cellular damage. PCD may also be involved in immune counteracti...
Activation and Costimulation of Intestinal T Cells: Independent and Collaborative Involvement of CD43, OX40, and Ly-6C [0.03%]
肠T细胞活化和共刺激：CD43、OX40和Ly-6C的独立及协作参与作用
Dina Montufar-Solis,John R Klein
Dina Montufar-Solis
T cells are present in large numbers in the epithelial lining of the small and large intestine of humans and mice. Those cells, referred to as intraepithelial lymphocytes (IELs), are critical for maintaining an effective mucosal immune resp...