Inflammatory Cyclooxygenase Activity and PGE2 Signaling in Models of Alzheimer's Disease [0.03%]
阿尔茨海默病模型中的炎症环氧合酶活性和PGE2信号转导
Jenny U Johansson,Nathaniel S Woodling,Ju Shi et al.
Jenny U Johansson et al.
The inflammatory response is a fundamental driving force in the pathogenesis of Alzheimer's disease (AD). In the setting of accumulating immunogenic Aß peptide assemblies, microglia, the innate immune cells of the brain, generate a non-res...
Scott W McPherson,Neal D Heuss,Ute Lehman et al.
Scott W McPherson et al.
Regulatory T cells (Tregs) are generated to antigens (Ag) found in the retina. Some Tregs are the result of ectopic expression of the retinal Ags in the thymus, where developing T cells are committed to enter the regulatory lineage. However...
Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections [0.03%]
趋化因子和免疫细胞在寄生虫感染中的作用及运输机制
Kathryn E McGovern,Emma H Wilson
Kathryn E McGovern
Parasites are diverse eukaryotic pathogens that can have complex life cycles. Their clearance, or control within a mammalian host requires the coordinated effort of the immune system. The cell types recruited to areas of infection can comba...
Do you see what I see: Recognition of protozoan parasites by Toll-like receptors [0.03%]
你是否能看到我的看见： toll样受体对原生动物寄生虫的识别
Debopam Ghosh,Jason S Stumhofer
Debopam Ghosh
Toll-like receptors (TLRs) are important for recognizing a variety of pathogens, including protozoan parasites, and initiating innate immune responses against them. TLRs are localized on the cell surface as well as in the endosome, and are ...
NKT Cell Subsets Can Exert Opposing Effects in Autoimmunity, Tumor Surveillance and Inflammation [0.03%]
NKT细胞亚群在自身免疫、肿瘤监视和炎症中可以产生相反的作用
Rachael Viale,Randle Ware,Igor Maricic et al.
Rachael Viale et al.
The innate-like natural killer T (NKT) cells are essential regulators of immunity. These cells comprise at least two distinct subsets and recognize different lipid antigens presented by the MHC class I like molecules CD1d. The CD1d-dependen...
Sean Lund,Hannah H Walford,Taylor A Doherty
Sean Lund
Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory and gastrointestinal tissue as well as in skin. Studies from...
Ryan A Zander,Noah S Butler
Ryan A Zander
Parasite-driven dysfunctional adaptive immunity represents an emerging hypothesis to explain the chronic or persistent nature of parasitic infections, as well as the observation that repeated exposure to most parasitic organisms fails to en...
Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection [0.03%]
效应T细胞和效应记忆T细胞在慢性感染中的分化方向
Michael M Opata,Robin Stephens
Michael M Opata
As effector memory T cells (Tem) are the predominant population elicited by chronic parasitic infections, increasing our knowledge of their function, survival and derivation, as phenotypically and functionally distinct from central memory a...
Alternatively Activated Macrophages Revisited: New Insights into the Regulation of Immunity, Inflammation and Metabolic Function following Parasite Infection [0.03%]
重新审视交替激活的巨噬细胞：后寄生虫感染免疫、炎症和代谢功能调节的新见解
Jessica C Jang,Meera G Nair
Jessica C Jang
The role of macrophages in homeostatic conditions and the immune system range from clearing debris to recognizing and killing pathogens. While classically activated macrophages (CAMacs) are induced by T helper type 1 (Th1) cytokines and exh...
Nicolas Villarino,Nathan W Schmidt
Nicolas Villarino
Parasitic protozoa are major threats to human health affecting millions of people around the world. Control of these infections by the host immune system relies on a myriad of immunological mechanisms that includes both humoral and cellular...