Joseph D Lamplot,Sahitya Denduluri,Jiaqiang Qin et al.
Joseph D Lamplot et al.
Osteosarcoma (OS) is the most common non-hematologic malignant tumor of bone in adults and children. As sarcomas are more common in adolescents and young adults than most other forms of cancer, there are a significant number of years of lif...
Biological and Clinical Implications of Clonal Heterogeneity and Clonal Evolution in Multiple Myeloma [0.03%]
浆细胞瘤的克隆异质性和克隆演化对生物学和临床治疗的意义
Giada Bianchi,Irene M Ghobrial
Giada Bianchi
Clonal heterogeneity and clonal evolution have emerged as critical concepts in the field of oncology over the past four decades, largely thanks to the implementation of novel technologies such as comparative genomic hybridization, whole gen...
Amy A Mrazek,Joseph R Carmical,Thomas G Wood et al.
Amy A Mrazek et al.
Cells in the stromal microenvironment facilitate colorectal cancer (CRC) progression and "co-evolve" with the epithelial cancer cells. Genetic and epigenetic differences between normal colorectal mucosa fibroblasts (NF) and carcinoma-associ...
Douglas G McNeel,Jordan T Becker,Laura E Johnson et al.
Douglas G McNeel et al.
Delivery of plasmid DNA encoding an antigen of interest has been demonstrated to be an effective means of immunization, capable of eliciting antigen-specific T cells. Plasmid DNA vaccines offer advantages over other anti-tumor vaccine appro...
Testicular Germ Cell Tumors: A Paradigm for the Successful Treatment of Solid Tumor Stem Cells [0.03%]
睾丸生殖细胞肿瘤：成功治疗实体瘤干细胞的典范
Caryl J Giuliano,Sarah J Freemantle,Michael J Spinella
Caryl J Giuliano
Treatment of testicular germ cell tumors (TGCTs) has been a success primarily due to the exquisite responsiveness of this solid tumor to cisplatin-based therapy. Despite the promise of cure for the majority of TGCT patients, the effectivene...
Beta-adrenergic signaling in the development and progression of pulmonary and pancreatic adenocarcinoma [0.03%]
β肾上腺素能信号在肺和胰腺腺癌的发展和进展中的作用
Hildegard M Schuller,Hussein A N Al-Wadei
Hildegard M Schuller
Small airway epithelial cells from, which most pulmonary adenocarcinomas (PACs) derive, and pancreatic duct epithelia, from which pancreatic ductal adenocarcinomas (PDACs) originate, share the ability to synthesize and release bicarbonate. ...
Ticiana Leal,Julie E Chang,Minesh Mehta et al.
Ticiana Leal et al.
As therapeutic options and supportive care for the treatment of neoplastic disease have improved, there has been an associated increase in the incidence of leptomeningeal disease. In this review, the clinical presentation, natural history, ...
Frederick Arce,Karine Breckpot,Mary Collins et al.
Frederick Arce et al.
Delivery of tumour-associated antigens (TAA) in a way that induces effective, specific immunity is a challenge in anti-cancer vaccine design. Circumventing tumour-induced tolerogenic mechanisms in vivo is also critical for effective immunot...
microRNAs, Gap Junctional Intercellular Communication and Mesenchymal Stem Cells in Breast Cancer Metastasis [0.03%]
乳腺癌转移中微小核糖核酸、缝隙连接通讯及间充质干细胞的作用
Larissa A Gregory,Rachel A Ricart,Shyam A Patel et al.
Larissa A Gregory et al.
The failed outcome of autologous bone marrow transplantation for breast cancer opens the field for investigations. This is particularly important because the bone marrow could be a major source of cancer cells during tertiary metastasis. Th...
Shuping Li,Soichiro Ibaragi,Guo-Fu Hu
Shuping Li
Angiogenin (ANG), a 14 kDa angiogenic ribonuclease, is upregulated in human prostate cancers, especially in hormone refractory diseases, and is the highest upregulated gene in Akt-driven prostate intraepithelial neoplasia (PIN) in mice. ANG...