Quantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract [0.03%]
年龄相关性核性白内障的发生发展过程中晶状体和房水代谢组变化的定量分析
Vadim V Yanshole,Lyudmila V Yanshole,Olga A Snytnikova et al.
Vadim V Yanshole et al.
Introduction: Metabolites are essential for the proper functioning of the eye lens, they either enter the lens from the aqueous humor (AH), or are synthesized in the lens epithelium. Antioxidants, osmolytes and UV filters...
Metabolomics analysis reveals global acetoin stress response of Bacillus licheniformis [0.03%]
代谢组分析揭示了地衣芽孢杆菌的丙酮酸全球压力响应机制
Honglun Yuan,Yong Xu,Yaozhong Chen et al.
Honglun Yuan et al.
Introduction: Acetoin serves as a high value-added platform with a broad range of applications, and can be effectively produced by Bacillus licheniformis. However, its toxicity to the producing strain hinders the higher a...
Dimitra Diamantidou,Anastasia Zotou,Georgios Theodoridis
Dimitra Diamantidou
Introduction: Mass spectrometry (MS)-based and nuclear magnetic resonance (NMR) spectroscopic analyses play a key role in the field of metabolomics due to their important advantages. The use of metabolomics in wine and gr...
Selective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts [0.03%]
基于丙酮酸脱氢酶及复合物I缺陷的人体皮肤纤维母细胞的选择性半乳糖培养条件及其不同的代谢标志
Damian Hertig,Andrea Felser,Gaëlle Diserens et al.
Damian Hertig et al.
Introduction: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders. ...
Global urinary metabolic profiling of the osteonecrosis of the femoral head based on UPLC-QTOF/MS [0.03%]
基于UPLC-QTOF/MS的股骨头坏死尿液代谢组学研究
Gang Yang,Gang Zhao,Jian Zhang et al.
Gang Yang et al.
Introduction: Osteonecrosis of the femoral head (ONFH), one of the widespread orthopedic diseases with a decrease in bloodstream to the femoral head, is frequently accompanied by cellular death, trabecula fracture, and co...
Untargeted metabolomics analysis of the upper respiratory tract of ferrets following influenza A virus infection and oseltamivir treatment [0.03%]
奧司他韦治疗后流感病毒感染雪貂上呼吸道的非靶向代谢组学分析
David J Beale,Ding Yuan Oh,Avinash V Karpe et al.
David J Beale et al.
Introduction: Influenza is a highly contagious respiratory disease that causes high global morbidity and mortality each year. The dynamics of an influenza infection on the host metabolism, and how metabolism is altered in...
Metabolomics in epidemiologic research: challenges and opportunities for early-career epidemiologists [0.03%]
代谢组学在流行病学研究中的挑战与机遇——对年轻流行病学家的建议
Eline H van Roekel,Erikka Loftfield,Rachel S Kelly et al.
Eline H van Roekel et al.
Background: The application of metabolomics to epidemiologic studies is increasing. Aim of review: Here, we describe the challenges and...
Metabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for Yersinia pestis [0.03%]
代谢组分析揭示了非人类灵长类动物耶尔森氏鼠疫耶尔森氏菌模型中的脂质异常和肝功能障碍
Aarti Gautam,Seid Muhie,Nabarun Chakraborty et al.
Aarti Gautam et al.
Introduction: Pneumonic plague is caused by the aerosolized form of Yersinia pestis and is a highly virulent infection with complex clinical consequences, and without treatment, the fatality rate approaches 100%. The exac...
Metabolomics would like to thank all our referees for their support in 2018 [0.03%]
代谢组学杂志想对所有评审人在2018年的支持表示感谢
Royston Goodacre
Royston Goodacre
Tissue-specific differences in metabolites and transcripts contribute to the heterogeneity of ricinoleic acid accumulation in Ricinus communis L. (castor) seeds [0.03%]
蓖麻种子中蓖麻油酸积累异质性的组织特异性代谢物和转录组差异分析
Drew Sturtevant,Trevor B Romsdahl,Xiao-Hong Yu et al.
Drew Sturtevant et al.
Introduction: Castor (Ricinus communis L.) seeds are valued for their production of oils which can comprise up to 90% hydroxy-fatty acids (ricinoleic acid). Castor oil contains mono-, di- and tri- ricinoleic acid containi...