Metabolic insights into the pathophysiology of tuberculous meningitis in FFPE postmortem human brain tissue [0.03%]
关于结核性脑膜炎病理生理的代谢见解——来自FFPE石蜡包埋人脑组织的视角
Abisola R Isaiah,Du Toit Loots,Aurelia A Williams et al.
Abisola R Isaiah et al.
Background: Tuberculous meningitis (TBM), caused by Mycobacterium tuberculosis, is the most severe form of extrapulmonary tuberculosis and isassociated with high morbidity and mortality, particularly when diagnosis is del...
Analysis of serum NMR metabolomics in fibrotic diseases of the myocardium [0.03%]
心肌纤维化疾病血清NMR代谢组学分析
Mark V Füzesi,Ella J Zhang,Rajshree Ghosh Biswas et al.
Mark V Füzesi et al.
Introduction: Heart failure accounts for more than 43% of annual deaths worldwide, and isdriven by widespread pathological remodeling, in which myocardial fibrosis plays an important role. Currently, accurate clinical dia...
Select plasma oxylipins as potential biomarkers of effective indomethacin treatment response in preterm infants with patent ductus arteriosus [0.03%]
选择血浆氧脂素作为早产儿动脉导管未闭有效吲哚美辛治疗反应潜在生物标志物的筛选
Khanh C K Nguyen,Cindy H T Yeung,Allison Scott et al.
Khanh C K Nguyen et al.
Objectives: Patent ductus arteriosus (PDA) is one of the most common heart conditions in preterm infants, and indomethacin treatment is used for PDA closure. However, its efficacy varies among patients. This pilot study a...
Targeted and Untargeted Urinary Metabolomic Analyses of Organophosphate Pesticides Exposure and Attention-Deficit/Hyperactivity Disorder in Children [0.03%]
儿童有机磷农药暴露和注意缺陷多动障碍的靶向和非靶向尿代谢组分析
Hsin-Yun Tseng,Chi-Jen Lo,Boopathi Subramani et al.
Hsin-Yun Tseng et al.
Introduction: Exposure to organophosphate pesticides (OPs) has been associated with increased oxidative stress and a higher risk of attention-deficit/hyperactivity disorder (ADHD). However, metabolic insights underlying A...
Multivariate analysis of metabolomic data to identify biological pathways modified by a clinical intervention [0.03%]
多元分析代谢组数据以识别临床干预措施所修改的生物通路
Rachel M Wood,Laura J Corbin,Jane M Blazeby et al.
Rachel M Wood et al.
Introduction: High throughput metabolomic assays offer a huge opportunity to quantify the cellular processes underlying disease and intervention pathways. However, the multi-dimensional inter-relatedness between these pro...
Urinary and cellular volatile organic compounds as biomarkers for urological cancers: a systematic review of GC-MS-based volatolomics [0.03%]
尿液和细胞挥发性有机化合物作为泌尿系统癌症的生物标志物：基于GC-MS的挥发组学的系统评价
Boyu Xie,Qing Wen
Boyu Xie
Introduction: Volatile organic compounds (VOCs) in human biofluids are promising non-invasive cancer biomarkers. However, their potential in urological cancers, including prostate, bladder, and kidney cancers is less expl...
Integrated workflow for univariate and multivariate evaluation of batch correction reliability [0.03%]
单变量和多变量评估批次修正可靠性的集成工作流程
Elfried Salanon,Blandine Comte,Delphine Centeno et al.
Elfried Salanon et al.
Introduction: Assessing batch correction methods remains a major challenge in metabolomics, as no consensus currently exists for a generic and reliable evaluation strategy. Given the strong influence of batch effects on d...
Broad-coverage targeted lipidomics reveals stage-specific lipid metabolic profiles and diagnostic and prognostic marker panels in ischemic stroke [0.03%]
基于靶向脂质组学的脑梗死阶段特异性脂质代谢特征及诊断和预后标志物研究
Haoran Huang,Liu Liu,Can Zhao et al.
Haoran Huang et al.
Background: Ischemic stroke (IS) is a major cause of mortality and disability globally, with challenges in early diagnosis and prognosis prediction. Dysregulated lipid metabolism is key to IS pathophysiology, but comprehe...
Integrative multi-omics analysis unravels the metabolic landscape and reveals serum biomarkers for early diagnosis of hyperuricemia [0.03%]
整合多组学分析解析高尿酸血症代谢图谱并发现血清生物标志物
Xin Sun,Baoying Gong,Ye Sun et al.
Xin Sun et al.
Background: Hyperuricemia (HUA) is a major risk factor for gout and multiple metabolic disorders. Although serum uric acid (UA) is the gold standard for HUA diagnosis, it fails to reflect early metabolic disturbances and ...
Pre-diagnostic metabolites in peripheral blood of Langerhans cell histiocytosis children with posterior pituitary involvement [0.03%]
兰伯病伴视神经受累患儿外周血中疾病预测代谢产物研究
Na Li,Xiaoxi Zhao,Lu Shi et al.
Na Li et al.
Background: Langerhans cell histiocytosis (LCH) is an inflammatory and neoplastic disorder. The levels of metabolites in the plasma of children with LCH have not been studied and may be related to disease progression. ...