Gender specific decrease of a set of circulating N-acylphosphatidyl ethanolamines (NAPEs) in the plasma of Parkinson's disease patients [0.03%]
帕金森病患者血浆中一组循环N-酰基磷脂醇乙醇胺(NAPEs)的性别特异性下降
Zeeshan Hamid,Abdul Basit,Silvia Pontis et al.
Zeeshan Hamid et al.
Introduction: Current markers of Parkinson's disease (PD) fail to detect the early progression of disease state. Conversely, current omics techniques allow the investigation of hundreds of molecules potentially altered by...
Sex and puberty-related differences in metabolomic profiles associated with adiposity measures in youth with obesity [0.03%]
肥胖青少年与肥胖相关的代谢组学谱系中性别和青春期相关差异的探讨
Christoph Saner,Brooke E Harcourt,Ahwan Pandey et al.
Christoph Saner et al.
Background: Specific patterns of metabolomic profiles relating to cardiometabolic disease are associated with increased weight in adults. In youth with obesity, metabolomic data are sparse and associations with adiposity ...
Addressing the pitfalls when designing intervention studies to discover and validate biomarkers of habitual dietary intake [0.03%]
谨防设计用于发现和验证反映常规膳食摄入生物标志物的干预研究时出现失误
A J Lloyd,N D Willis,T Wilson et al.
A J Lloyd et al.
Introduction: Dietary exposure monitoring within populations is reliant on self-reported measures such as Food Frequency Questionnaires and diet diaries. These methods often contain inaccurate information due to participa...
Randomized Controlled Trial
Metabolomics : Official journal of the Metabolomic Society. 2019 May 2;15(5):72. DOI:10.1007/s11306-019-1532-3 2019
High-resolution MS/MS metabolomics by data-independent acquisition reveals urinary metabolic alteration in experimental colitis [0.03%]
基于数据非依赖性采集的高分辨率多级质谱代谢组学研究实验性结肠炎的尿液代谢变化
Zhixiang Yan,Ting Li,Bin Wei et al.
Zhixiang Yan et al.
Introduction: Traditional high-resolution MS1 based untargeted metabolomics suffers from low sensitivity, while low-resolution MS/MS based multiple reaction monitoring increases sensitivity at the cost of metabolite cover...
Metabolic perturbations caused by depletion of nephronophthisis factor Anks6 in mIMCD3 cells [0.03%]
肾脏萎缩因子Anks6缺失对mIMCD3细胞代谢的扰动效应
Manuel Schlimpert,Simon Lagies,Barbara Müller et al.
Manuel Schlimpert et al.
Introduction: Nephronophthisis (NPH) is an inherited form of cystic kidney disease with various extrarenal manifestations accounting for the largest amount of endstage renal disease in childhood. Patient mutations of Anks...
An integrated genomic and metabolomic approach for defining survival time in adult oligodendrogliomas patients [0.03%]
整合基因组和代谢组方法定义成人少突胶质瘤患者的生存期
Caroline Bund,Mariana Guergova-Kuras,A Ercument Cicek et al.
Caroline Bund et al.
Introduction: The identification of frequent acquired mutations shows that patients with oligodendrogliomas have divergent biology with differing prognoses regardless of histological classification. A better understanding...
Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging [0.03%]
采用质谱成像法评估nitisinone诱导的高酪氨酸血症对阿尔卡تون尿症小鼠模型脑组织单胺神经递质的影响
A S Davison,N Strittmatter,H Sutherland et al.
A S Davison et al.
Objective: Nitisinone induced hypertyrosinaemia is a concern in patients with Alkaptonuria (AKU). It has been suggested that this may alter neurotransmitter metabolism, specifically dopamine and serotonin. Herein mass spe...
Impact of different elicitors on grapevine leaf metabolism monitored by 1H NMR spectroscopy [0.03%]
不同诱导子对葡萄叶代谢影响的核磁共振研究
Aleksandra Burdziej,Grégory Da Costa,Louis Gougeon et al.
Aleksandra Burdziej et al.
Introduction: Grapevine protection is an important issue in viticulture. To reduce pesticide use, sustainable disease control strategies are proposed, including a promising alternative method based on the elicitor-trigger...
Royston Goodacre
Royston Goodacre
Roxana Coras,Arthur Kavanaugh,Tristan Boyd et al.
Roxana Coras et al.
Introduction: Eicosanoids are biological lipids that serve as both activators and suppressors of inflammation. Eicosanoid pathways are implicated in synovitis and joint destruction in inflammatory arthritis, yet they migh...