Identification of chemotypes in bitter melon by metabolomics: a plant with potential benefit for management of diabetes in traditional Chinese medicine [0.03%]
基于代谢组学的苦瓜化学类型鉴定及其在传统中医药中用于糖尿病防治的潜在价值研究
Shuaizhen Zhou,Pierre-Marie Allard,Christian Wolfrum et al.
Shuaizhen Zhou et al.
Introduction: Bitter melon (Momordica charantia, Cucurbitaceae) is a popular edible medicinal plant, which has been used as a botanical dietary supplement for the treatment of diabetes and obesity in Chinese folk medicine...
A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics [0.03%]
对来自异质性生物样品的目标代谢组数据进行大规模分析可提供代谢物动态的见解
Ho-Joon Lee,Daniel M Kremer,Peter Sajjakulnukit et al.
Ho-Joon Lee et al.
Introduction: We previously developed a tandem mass spectrometry-based label-free targeted metabolomics analysis framework coupled to two distinct chromatographic methods, reversed-phase liquid chromatography (RPLC) and h...
Multiple metabolic pathways are predictive of ricin intoxication in a rat model [0.03%]
多种代谢通路预测蓖麻毒素致大鼠中毒的效果
Riccardo V D&#x;Elia,Sarah A Goodchild,Catherine L Winder et al.
Riccardo V D&#x;Elia et al.
Introduction: Exposure to ricin can be lethal and treatments that are under development have short windows of opportunity for administration after exposure. It is therefore essential to achieve early detection of ricin ex...
Metabolomic profiling of the excretory-secretory products of hookworm and whipworm [0.03%]
钩虫和 whipworm 的代谢组学分析及分泌物排泄物的概况
Phurpa Wangchuk,Konstantinos Kouremenos,Ramon M Eichenberger et al.
Phurpa Wangchuk et al.
Introduction: Soil-transmitted helminths infect billions of people, livestock and companion animals worldwide, and chronic infections with these nematodes represent a major health burden in many developing countries. On t...
Metabolomic profiling suggests systemic signatures of premature aging induced by Hutchinson-Gilford progeria syndrome [0.03%]
代谢组学特征分析提示Hutchinson-Gilford早老症综合症引起的全身性衰老迹象
Gustavo Monnerat,Geisa Paulino Caprini Evaristo,Joseph Albert Medeiros Evaristo et al.
Gustavo Monnerat et al.
Introduction: Hutchinson-Gilford Progeria Syndrome (HGPS) is an extremely rare genetic disorder. HGPS children present a high incidence of cardiovascular complications along with altered metabolic processes and an acceler...
Metabolic profiling in children with autism spectrum disorder with and without mental regression: preliminary results from a cross-sectional case-control study [0.03%]
自闭症谱系障碍儿童代谢轮廓的测定：横断面病例对照研究的初步结果（具/不具备精神倒退）
O D Rangel-Huerta,A Gomez-Fernández,M J de la Torre-Aguilar et al.
O D Rangel-Huerta et al.
Introduction: It is challenging to establish the mechanisms involved in the variety of well-defined clinical phenotypes in autism spectrum disorder (ASD) and the pathways involved in their pathogeneses. ...
Untargeted metabolomic analysis of coronary artery disease patients with diastolic dysfunction show disturbed oxidative pathway [0.03%]
未目标代谢组学分析冠心病合并舒张功能障碍患者显示氧化途径紊乱
Tamkeen Fatima,Satwat Hashmi,Ayesha Iqbal et al.
Tamkeen Fatima et al.
Introduction: Left ventricular diastolic dysfunction (LVDD) is common in patients with coronary artery disease (CAD) with prevalence estimates of 34% and constitutes a predictor of all-cause mortality. Although diastolic ...
Targeted metabolomics to investigate antimicrobial activity of itaconic acid in marine molluscs [0.03%]
靶向代谢组学研究衣康酸对海洋软体动物的抗菌活性
Thao Van Nguyen,Andrea C Alfaro
Thao Van Nguyen
Introduction: Itaconic acid (ITA) has recently been identified as an antimicrobial metabolite in mammalian immune cells. The presence of ITA was also reported in different tissues of marine molluscs, indicating its role a...
Comprehensive metabolomic and proteomic analyses reveal candidate biomarkers and related metabolic networks in atrial fibrillation [0.03%]
全面代谢组学和蛋白质组学分析揭示了房颤中的候选生物标志物及相关代谢网络
Juntuo Zhou,Lijie Sun,Liwen Chen et al.
Juntuo Zhou et al.
Introduction: Atrial fibrillation (AF) is an abnormal heart rhythm characterized by an irregular beating of the atria and is associated with an increased risk of heart failure, dementia, and stroke. Currently, the perturb...
Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study [0.03%]
童年期间接触全氟烷基物质的代谢组学研究：横断面研究
Samantha L Kingsley,Douglas I Walker,Antonia M Calafat et al.
Samantha L Kingsley et al.
Introduction: Exposure to perfluoroalkyl substances (PFAS), synthetic and persistent chemicals used in commercial and industrial processes, are associated with cardiometabolic dysfunction and related risk factors includin...