Deciphering barley's stress response: metabolomic strategies and phenotypic implications under multiple abiotic stresses [0.03%]
麦类环境应答解析——多逆境胁迫下的代谢组学策略及表型效应
Michał Kempa,Anetta Kuczyńska,Piotr Ogrodowicz et al.
Michał Kempa et al.
Introduction: Plants are mainly influenced by abiotic stresses acting in combination rather than a single stress acting alone. In the present study leaf metabolomic profiles as well as changes in phenome and yield of four...
Understanding the metabolome of four stress-relieving and cognitive-enhancing medicinal plants: a comprehensive HR-LC-ESI-MS/MS analysis [0.03%]
四种缓解压力和改善认知的药用植物代谢组的研究：全面的高分辨率液相色谱-串联质谱分析
Muhammad Noman Khan,Syed Muhammad Zaki Shah,Saeedur Rahman et al.
Muhammad Noman Khan et al.
Purpose: High-resolution liquid chromatography–mass spectrometry (HR-LC-MS/MS) enables comprehensive metabolite profiling of medicinal plants. This study aimed to characterize the metabolomes of four stress-relieving and...
Polar microcystins or arginine methyl ester can serve as sensitive reference materials for system suitability tests in untargeted metabolomics using reversed-phase LC-MS: A case study [0.03%]
极性微囊藻毒素或精氨酸甲酯可作为反相液相色谱质谱Untargeted代谢组学系统适用性测试的敏感参考物质：一项案例研究
Tommy Melzer,Georg Pohnert,Nico Ueberschaar
Tommy Melzer
Introduction: LC-MS system suitability test (SST) is crucial for reliable data acquisition especially in untargeted metabolomics. Objectives: ...
Asymmetric dimethylguanidino valeric acid as an independently associated risk factor for early hypertriglyceridemia and dyslipidemia [0.03%]
不对称双甲基瓜尔酸伐伦酸作为早期高甘油三酯血症和血脂异常的独立危险因素
Yueyuan Han,Qianling Xiong,Jiahui Wang et al.
Yueyuan Han et al.
Introduction: Hypertriglyceridemia (HTG) is a crucial risk factor for cardiovascular disease, metabolic syndrome, and type 2 diabetes. However, its early detection remains challenging due to the dynamic fluctuations in pl...
Impact of sulfamethoxazole, trimethoprim, diclofenac, carbamazepine, and their mixture on the metabolism of Lemna minor: a targeted metabonomic study [0.03%]
四种医药和个人护理用品及其混合物对苦草代谢影响的靶向代谢组学研究
Rofida Wahman,Peter Schröder,Geoffroy Duporté et al.
Rofida Wahman et al.
Introduction: Metabolomics is an analytical profiling technique that measures and compares large numbers of metabolites in biological samples, providing insight into metabolic mechanisms. There are few studies concerning ...
Metabolomic profiling in phenylketonuria: a systematic review of human studies [0.03%]
苯酮尿症代谢组学谱分析：人类研究的系统综述
Arnau Gonzalez-Rodriguez,Mireia Urpi-Sarda,Blanca Barrau-Martinez et al.
Arnau Gonzalez-Rodriguez et al.
Background: Phenylketonuria (PKU) is a rare metabolic disorder caused by a deficiency in the enzyme phenylalanine hydroxylase, leading to the accumulation of phenylalanine (Phe). Raised Phe levels can result in neurocogni...
Application of untargeted plasma metabolomics and machine learning to construct a diagnostic model for hypertrophic cardiomyopathy: a case-control study [0.03%]
基于非靶向血浆代谢组学和机器学习构建肥厚型心肌病诊断模型的病例对照研究
Ruoxuan Li,Bo Wang,Bo Shan et al.
Ruoxuan Li et al.
Background: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease. Recent metabolomics studies have revealed pathogenic mechanisms and provided new perspectives for diagnosis. ...
Multiplexed LC-MS analysis reveals novel insights into grapevine defense mechanisms by expanding metabolome coverage [0.03%]
多重LC-MS分析通过扩展代谢组覆盖范围揭示了对葡萄vine防御机制的新见解
Pedro G Vásquez-Ocmín,Amelie Pérez,Ana Romeo-Oliván et al.
Pedro G Vásquez-Ocmín et al.
Introduction: Grapevine trunk diseases (GTDs), such as esca, pose a major threat to viticulture worldwide and are associated with complex biochemical responses in woody tissues. Comprehensive metabolome coverage remains a...
Exploring metabolic signatures in urine using NMR for improved prognosis of gliomas [0.03%]
基于核磁共振尿液代谢组学的胶质瘤预后研究
Aditi Pandey,Aanchal Datta,Rajeev Verma et al.
Aditi Pandey et al.
Introduction: Gliomas represent the tumors of the central nervous system that originate from glial cells. Overall survival predictions and treatment regimen selection are based on accurate tumor diagnosis and grading. How...
Artificial intelligence to investigate metabolomics data for precision medicine [0.03%]
人工智能研究代谢组学数据的精准医疗
Antony Shenouda,Sahana Senthilkumar,Youssef Mourad et al.
Antony Shenouda et al.
Background: Metabolomic data offers insights into disease mechanisms, diagnostics, and therapeutic targets by analyzing metabolic profiles. In analyzing these profiles, traditional bioinformatic and statistical approaches...