Metabolomics profiling of acute myelogenous leukemia patients to identify systemic differences associated with in vitro sensitivity to SYK inhibitors [0.03%]
急性髓系白血病患者代谢组学谱分析以识别SYK抑制剂体外敏感性相关的系统差异
Marte Karen Brattås,Kimberley Joanne Hatfield,Kristin Paulsen Rye et al.
Marte Karen Brattås et al.
Introduction: Acute myelogenous leukemia (AML) is a heterogeneous hematological malignancy. Despite therapeutic advances, high relapse rates and poor survival persist, underscoring the need for new treatment strategies. S...
Serum and urine metabolomic profiling in Miniature Schnauzer dogs with and without calcium oxalate urolithiasis [0.03%]
钙草酸尿石症小型 schnauzer 犬血清和尿液代谢组学特征分析
Emily L Coffey,Andres Gomez,Nicole M Tate et al.
Emily L Coffey et al.
Introduction: Calcium oxalate (CaOx) urolithiasis is associated with metabolic disorders, including dyslipidemia. Improved understanding of underlying metabolic derangements is needed. The Miniature Schnauzer presents an ...
Plasma 1H NMR-based metabolomic analysis reveals the lipid regulating effect of novel carboxamide derivatives in hyperlipidemic rats [0.03%]
基于全血浆1H核磁共振代谢组学分析评价新型羧酸胺衍生物调节高血脂症模型大鼠血脂水平的作用
Mohammad Alwahsh,Rahaf Alejel,Lama Hamadneh et al.
Mohammad Alwahsh et al.
Background: Hyperlipidemia refers to the abnormal elevation in the levels of one or more plasma lipids and lipoproteins. Aims: The purp...
Exploiting predictive metabolomics of pearl millet phenotypic traits using untargeted profiling across a Brazilian germplasm panel [0.03%]
利用无目标分析在巴西种质面板中发掘珍珠粟表型性状预测代谢组学
Mariana Pinheiro Costa Pimentel,Alexandre Martins Abdão Dos Passos,Sylvain Prigent et al.
Mariana Pinheiro Costa Pimentel et al.
Introduction: Pearl millet is a high nutritional cereal recognised for its agro-climatic resilience, making it relevant for food security under climate change scenarios. Phenotypic traits are indicative of crop performanc...
Univariate- and machine learning-based plasma metabolite signature differentiates PSC-IBD from IBD and is predicted to be driven by gut microbial changes [0.03%]
基于单变量和机器学习的血浆代谢标志物可区分PSC-IBD与IBD且预测由肠道微生物变化驱动
Joanna C Wolthuis,Johannes P D Schultheiss,Stefanía Magnúsdóttir et al.
Joanna C Wolthuis et al.
Introduction: Inflammatory bowel disease (IBD) is a group of chronic inflammatory conditions of the gastrointestinal tract comprising two major phenotypes, Crohn's disease (CD) and ulcerative colitis (UC). Up to 8% of pat...
Targeted metabolomics reveals the impact of glucose and pyruvate on energy metabolism and storage potential of stallion spermatozoa [0.03%]
靶向代谢组学揭示葡萄糖和丙酮酸对公马精细胞能量代谢及储能潜力的影响
Laura Becerro-Rey,Francisco Eduardo Martín-Cano,Antonio Silva-Rodríguez et al.
Laura Becerro-Rey et al.
Introduction: Oxidative phosphorylation is the main source of ATP for the stallion spermatozoa. Consequently, metabolites that favor mitochondrial function are receiving increased interest. However, glycolysis itself may ...
Multi-omics analyses reveal novel metabolic signatures of post-traumatic deep vein thrombosis in patients with coronary heart disease [0.03%]
多组学分析揭示冠心病患者的创伤后深静脉血栓形成的新代谢标志物
Mukhtar Aliyu,Kun Zhang,Wei Huang et al.
Mukhtar Aliyu et al.
Background: Post-traumatic Deep vein thrombosis (pt-DVT) is a serious health issue that often leads to considerable morbidity and mortality especially in patients with coronary heart disease (CHD). Diagnosis of DVT in a c...
Chemical diversity and species differentiation in Brazilian Vanilla: insights from LC-HRMS/MS metabolomics [0.03%]
巴西香荚兰的化学多样性和物种分化：基于LC-HRMS/MS代谢组学的见解
Gesiane S Lima,Giovanni B Bevilaqua,Hugo G Machado et al.
Gesiane S Lima et al.
Introduction: Vanilla species represent a taxonomically complex and economically important group of orchids, yet species discrimination and chemotaxonomic characterization remain challenging due to high intrageneric metab...
Correction: What's in a name? Metabolite identification: challenges and pitfalls in untargeted metabolomics [0.03%]
纠正：名称背后的意义——代谢物鉴定：非靶向代谢组学中的挑战与陷阱
Georgios Theodoridis,Oliver Fiehn,Michal Holčapek et al.
Georgios Theodoridis et al.
Outcomes and future activities of the 'Pan-European network in Lipidomics and EpiLipidomics - EpiLipidNET' [0.03%]
泛欧洲脂质组学和表观遗传脂质组学网络(EpiLipidNET) 的成果及其未来活动方向
Julia Kuligowski,Justine Bertrand-Michel,Amaury Cazenave-Gassiot et al.
Julia Kuligowski et al.
Background: Lipidomics and its branch epilipidomics are rapidly advancing fields that explore the roles of native and modified lipids (e.g., oxidized, nitrated and halogenated lipid species), respectively, in biological s...