Optimization of a targeted metabolomics kit for dried blood spots analysis and longitudinal comparison with serum [0.03%]
用于干燥血斑分析的靶向代谢组学试剂盒的优化与纵向血清的比较分析
Eleonora Bossi,Cornelia Prehn,Lia Crotti et al.
Eleonora Bossi et al.
Targeted metabolomics kit-based assays are widely used for quantitative metabolic profiling in clinical research. However, they are primarily validated for conventional matrices such as plasma and serum. Their direct application to dried bl...
Metabolic markers of kidney function and oxidative stress are associated with heart failure with preserved ejection fraction (HFpEF) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) [0.03%]
代谢功能标志物和氧化应激与代谢紊乱相关脂肪肝病患者心力衰竭伴射血分数保留型的关联
Kara Wegermann,Mengshu He,Lydia Coulter Kwee et al.
Kara Wegermann et al.
Background and aim: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with heart failure with preserved ejection fraction (HFpEF), independent of shared risk factors. The aim of this study was...
Urinary metabolites and fatigue in a population-based metabolomics study: an exploratory analysis [0.03%]
基于人群的代谢组学研究中疲劳与尿液代谢物的相关性分析：一项探索性分析
Annika Kneipp,Inge Kirchberger,Dennis Freuer et al.
Annika Kneipp et al.
Introduction: Nearly every fifth adult person suffers from chronic fatigue, but its etiology and related mechanisms are poorly understood. Metabolomics data offer new possibilities for identifying metabolites related to d...
Untargeted metabolomics reveals serum metabolites related to energy metabolism and inflammation associated with juvenile dermatomyositis [0.03%]
未靶向代谢组学揭示与系统性硬化症相关的能源代谢和炎症相关联的血清代谢物
Kaylie I Kirkwood-Donelson,Dylan J Johnson,Payam Noroozi Farhadi et al.
Kaylie I Kirkwood-Donelson et al.
Introduction: Juvenile dermatomyositis (JDM) is a rare autoimmune inflammatory myopathy characterized by muscle weakness and distinctive skin rashes. Despite advancements in the clinical understanding of JDM, metabolic di...
Time-dependent plasma metabolic shifts and mechanistic insights into systemic consequences of cerebral ischemia in middle-aged patients [0.03%]
基于中年人脑卒中的时间依赖性血浆代谢变化及系统后遗症的机制见解
Eva Baranovicova,Jana Dluha,Egon Kurca et al.
Eva Baranovicova et al.
Objectives: To investigate how acute ischemic stroke induces systemic metabolic reorganization and to characterize the temporal dynamics of these alterations in relation to stroke severity. ...
Metabolic and lipidomic stability in EDTA plasma from hospitalized patients: impact of refrigerated storage time and additional freeze-thaw cycle [0.03%]
Sander Johannes Thorbjørnsen Guttorm,Liana Gukasyan,Christian Prebensen et al.
Sander Johannes Thorbjørnsen Guttorm et al.
Background: Global metabolomics and lipidomics are increasingly applied in clinical research. Storage variability can compromise analyte stability and omics data quality, especially in clinical settings. While previous st...
Linking metabolism and metastasis: elevated α-hydroxybutyric acid in oral squamous cell carcinoma patients with lymph node metastasis [0.03%]
代谢与转移的关系：口腔鳞癌淋巴结转移患者α-羟基丁酸水平升高
Xiaolian Gu,Philip J Coates,Lixiao Wang et al.
Xiaolian Gu et al.
Introduction: Metabolic reprogramming is a hallmark of cancer. Plasma metabolomics offers a minimally invasive approach for identifying metabolic alterations that may provide insights into tumor progression. ...
Untargeted urinary metabolomics reveals metabolic alterations and severity biomarkers in cardiac surgery-associated acute kidney injury [0.03%]
未靶向尿液代谢组学揭示心脏手术相关急性肾损伤的代谢改变及严重程度生物标志物
Cheng-Chia Lee,Ya-Ju Hsieh,Chih-Hsiang Chang et al.
Cheng-Chia Lee et al.
Introduction: Cardiac surgery-associated acute kidney injury (CS-AKI) is a frequent, serious complication linked to increased morbidity, mortality, and long-term kidney dysfunction. Progress in early detection and effecti...
Metabolomic signatures suggest altered bile acid and energy metabolism in CRB1- retinopathies [0.03%]
代谢标志物提示CRB1突变相关视网膜病变中胆汁酸及能量代谢改变
Ana Catalina Rodriguez-Martinez,Neelima Nair,Jane Skinner et al.
Ana Catalina Rodriguez-Martinez et al.
Introduction: The human CRB1 gene encodes the CRB1 protein, primarily expressed in retinal Muller cells and photoreceptors, where it regulates apical-basal polarity and cellular signalling through its role in adherence ju...
Serum untargeted metabolomics reveals key pathways in feline mammary carcinoma for comparative oncology [0.03%]
基于猫乳腺癌的非靶向血清代谢组学研究及转化医学意义
Hanna Carvalho de Sá,Gabriel Menezes Rodrigues,Vitor de Moraes Pina de Carvalho et al.
Hanna Carvalho de Sá et al.
Background and aims: The development of breast cancer exhibits a heterogeneous and complex character in both felines and humans, which motivates the search for serum biomarkers for diagnosis, prognosis, and therapeutic mo...