Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts [0.03%]
宿主对SARS-CoV-2和流感病毒的代谢反应：相似性和差异性
Charles Terra,Olivier Terrier,Audrey Le Gouellec
Charles Terra
Background: SARS-CoV-2 and Influenza virus are two major respiratory viruses, responsible for the COVID-19 and the flu respectively. To achieve their replication, these viruses do not merely hijack host cells; they reprog...
A machine learning‑enhanced serum metabolomics model for non‑invasive detection of gastric cancer [0.03%]
一种机器学习增强的血清代谢组模型，用于非侵入性检测胃癌
Xiaoyu Ye,Jialiang Xing,Limin Niu et al.
Xiaoyu Ye et al.
Background: Gastric cancer (GC) is a leading cause of cancer-related deaths globally, with early detection crucial for improving survival. Current non-invasive biomarkers lack sensitivity in early stages, necessitating mo...
An LC-MS untargeted metabolomic comparison between three blood microsampling devices, whole blood, and plasma [0.03%]
三种血微取样装置、全血和血浆的非靶向代谢组比较研究（LC-MS）
Dennisse Avella,Soile Turunen,Glykeria Avgerinou et al.
Dennisse Avella et al.
Introduction: Blood microsampling (BµS) devices collect less than 100 µL of blood, offering a less invasive and more cost-effective alternative to venipuncture. However, its metabolomic comparability to conventional sam...
Brian L Lee,Alanne Tenório Nunes,Prashanthi Kovur et al.
Brian L Lee et al.
Introduction: Human breast milk is the optimal source of nutrition for newborns and contains hundreds of bioactive compounds that influence infant health and development. Characterizing its composition at scale is importa...
Bioactivity-guided metabolomics reveals discriminant cytotoxic signatures in Siparuna guianensis [0.03%]
生物活性导向代谢组学揭示了Siparuna guianensis中的鉴别细胞毒性标志物
Salva Asghar,Giovanni B Bevilaqua,Gracimerio J Guarneire et al.
Salva Asghar et al.
Introduction: Natural products remain a privileged source of structurally diverse bioactive compounds with potential for the development of safer and more selective anticancer agents. ...
NMR-based metabolomics profile during a soccer season of a sub-elite soccer team [0.03%]
基于核磁共振代谢组学的足球赛季中低级别职业球队运动员体内的代谢轮廓变化分析
Alisson Henrique Marinho,Filipe Antonio de Barros Sousa,Pedro Balikian Junior et al.
Alisson Henrique Marinho et al.
Purpose: This study aimed to characterize metabolomic profiling, match performance, and GPS-derived variables across the competitive season of a sub-elite soccer team. ...
Assessing the metabolomics "dark matter" by a detectable khipu model [0.03%]
可检测胡珀模型在代谢组学“暗物质”评估中的应用
Yuanye Chi,Joshua M Mitchell,Shujian Zheng et al.
Yuanye Chi et al.
Background There is no consensus on how to interpret the large number of unknown features in untargeted metabolomics, which are sometimes referred as the "dark matter". Are these features real compounds or artifacts? Understanding this prob...
Identification of salivary lipid biomarkers for noninvasive diagnosis of reflux esophagitis via UHPLC-MS-based lipidomics [0.03%]
基于UHPLC-MS脂质组学鉴定唾液脂质生物标志物以实现反流性食管炎的无创诊断
Ying Wang,Ying Zhou,Jian Gao et al.
Ying Wang et al.
Introduction: Reflux esophagitis (RE) is a common upper gastrointestinal disorder, and its diagnosis currently relies primarily on invasive endoscopic examination. The lack of reliable non-invasive biomarkers substantiall...
Effect of TMEM18 rs7561317 on metabolome in context of obesity [0.03%]
TMEM18基因rs7561317多态性通过改变肥胖表型的代谢组以影响肥胖发生发展的作用机制研究
Sabiha Farooq,Sobia Rana,Amna Jabbar Siddiqui et al.
Sabiha Farooq et al.
Introduction: TMEM18 has been indicated by genome-wide association studies as a key gene linked to obesity, yet its exact function and connections with major metabolic networks are unknown. ...
The faecal bulk heterogeneity: implications for homogenisation and spot-sampling strategies for metabolomic investigations [0.03%]
粪便样品的异质性：对代谢组学研究中匀浆和抽样策略的影响
Eliska Jenickova,Anna Mascellani Bergo,Chandrama Roy Chowdhury et al.
Eliska Jenickova et al.
Introduction: Faecal metabolomics investigates small molecules in stool to elucidate metabolic pathways and identify potential biomarkers. However, topographical heterogeneity within individual stool specimens poses a cha...