Serum metabolomic signatures integrating sphingosine-1-phosphate and tetrahydrocortisone improve prognostic assessment in non-ischemic cardiomyopathy [0.03%]
鞘氨醇-1-磷酸和四氢皮质酮整合的血清代谢标志物可改善非缺血性心肌病预后的评估
Fanglu Wang,Benchen Ye,Ligang Fang et al.
Fanglu Wang et al.
Introduction: Dilated cardiomyopathy (DCM) and left ventricular non-compaction (LVNC) are major non-ischemic cardiomyopathy (NICM) subtypes with heterogeneous outcomes. Conventional clinical and echocardiographic markers ...
Characterization of three new antiproliferative shikimic acid derivatives and known pyrrolizidine alkaloids from Senecio oleosus guided by diagnostic ions and molecular networking [0.03%]
基于诊断离子和分子网络指导的Senecio oleosus中三种新的抗增殖莽草酸衍生物和已知吡咯烷生物碱的鉴定
Nathália da Silva Malaco,Anderson Valdiney Gomes Ramos,Bruno Toschi Valeze et al.
Nathália da Silva Malaco et al.
Introduction: The genus Senecio comprises more than 1,200 species, at least 25 of which are known to be toxic due to the presence of pyrrolizidine alkaloids. In Brazil, approximately 68 species occur, predominantly in rur...
Urinary volatile organic compounds as potential non-invasive markers for childhood obesity [0.03%]
尿挥发性有机化合物可能作为儿童肥胖非侵入式标志物
Adebowale Samuel Oyerinde,Jeremy Carson,Mallory Gibson et al.
Adebowale Samuel Oyerinde et al.
Background: Childhood obesity is a complex disease and adversely affects multiple organ systems and increases the risk for several health problems, including diabetes, cancer, atherosclerosis, and premature cardiovascular...
Lipid reprogramming of stratified squamous epithelium by the high-risk HPV E6 and E6/E7 oncoproteins [0.03%]
高危HPV E6和E6/E7癌蛋白对分化鳞状上皮细胞的脂质重塑作用
Megan E Spurgeon,Taylor E Lange,Alexandra Baty et al.
Megan E Spurgeon et al.
Introduction: High risk human papillomavirus (HPV) infection and genome integration with pronounced expression of the viral E6/E7 oncogenes is the major cause of cervical cancer. Emerging evidence suggests that HPV reprog...
Secondary metabolite profiling of rare Micromonospora spp. from cold desert of NW Himalayas via multi-omics analysis [0.03%]
基于多组学分析的西北喜马拉雅冷沙漠中罕见Micromonospora种特异性次级代谢产物研究
Neha Sharma,Devtulya Chander,Nawaz Hussain et al.
Neha Sharma et al.
Introduction: The genus Micromonospora is a prolific producer of specialized metabolites with pharmacological and agronomic relevance. Natural products derived from the genus Micromonospora have a distinctive chemical div...
Fecal metabolome alterations in infants at risk of developing allergies during the first year of life [0.03%]
高风险婴儿出生后第一年内发生过敏与粪便代谢组变化的关系研究
Mariyana V Savova,Pingping Zhu,Alida Kindt;TEMPO study team;Harm Wopereis et al.
Mariyana V Savova et al.
Introduction: Disturbances in the infant gut microbiome (GM) may increase the risk of developing allergies. This critical developmental period is characterized by rapid microbial colonization, which is influenced by facto...
Association of handgrip strength with the plasma metabolomic profile: secondary analysis of a protein intervention study [0.03%]
握力与血浆代谢谱型的关联：蛋白干预研究的二次分析
Tilde Martinsen,Janine Wirth,Lorraine Brennan
Tilde Martinsen
Introduction: There is interest in the potential impact of increased protein intake on muscle function in older adults. However, there is paucity of information on effects of different protein types. ...
Randomized Controlled Trial
Metabolomics : Official journal of the Metabolomic Society. 2026 Jun 30;22(4):106. DOI:10.1007/s11306-026-02496-4 2026
Next-generation newborn screening: feasibility of combined genetic and biochemical testing for 95 treatable inherited metabolic disorders [0.03%]
下一代新生儿筛查：95种可治疗的遗传性代谢病组合基因和生化检测的可行性研究
Abigail Veldman,C Edel Arar,M B Gea Kiewiet et al.
Abigail Veldman et al.
Introduction: Next-generation sequencing (NGS) is gaining attention in newborn screening (NBS) for its ability to detect treatable genetic disorders, especially those without a biochemical footprint. However, NGS-NBS requ...
A priori sample size determination and power analysis in metabolic phenotyping and integrative metabolomics: an application framework based on a systematic review of literature [0.03%]
基于文献系统综述的代谢表型和整合代谢组学中的样本量计算与功效分析框架研究
Nicola Luigi Bragazzi,Sara Dobani,José Fernando Rinaldi de Alvarenga et al.
Nicola Luigi Bragazzi et al.
In biomedical research, predetermining the appropriate number of samples is essential to ensure the validity of findings, optimize resource allocation, and support meaningful scientific discovery. Accurate sample size estimation is particul...
Untargeted metabolomics and proteomics reveals cocoa-mediated mitigation of valproic acid-induced dysregulation in a zebrafish model of autism: pilot study [0.03%]
未靶向代谢组学和蛋白质组学揭示了可可介导的全氟酸诱导的斑马鱼自闭症模型中失调的缓解：初步研究
Jeffrey Li,Isra&#x;a Haj-Husein,Nathan Ghafari et al.
Jeffrey Li et al.
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by behavioral impairments and limited therapeutic options. Emerging evidence suggests that plant-derived polyphenols may offer n...