Diagnostic and therapeutic potential of serum fatty acids in hyperlipidemia: evidence from three cohorts of patients with coronary atherosclerotic heart disease [0.03%]
来自冠状动脉粥样硬化性心脏病患者的三项队列研究证明血脂异常诊断及治疗中血清脂肪酸的潜在价值
Haiyan Cao,Furong Zhao,Hongbo Liu et al.
Haiyan Cao et al.
Background: Hyperlipidemia is a major risk factor for coronary atherosclerotic heart disease (CAHD). However, conventional lipid profiling fails to fully reflect the complexity of lipid metabolism. Furthermore, while lipi...
Reduced lipid metabolite abundance in human pancreatic cancer and matched serum samples following neoadjuvant FOLFIRINOX treatment [0.03%]
新辅助FOLFIRINOX治疗后人类胰腺癌和配对血清样本中脂质代谢物丰度降低
Manoj Amrutkar,Sander Johannes Thorbjørnsen Guttorm,Knut Jørgen Labori et al.
Manoj Amrutkar et al.
Introduction: Exploiting the full potential of neoadjuvant treatment (NAT) in pancreatic ductal adenocarcinoma (PDAC) is hampered by the lack of biomarkers for treatment response. Dysregulated lipid metabolism has been su...
Characterizing the tuberculosis and type 2 diabetes mellitus comorbidity in a South African cohort using untargeted GCxGC-TOFMS metabolomics [0.03%]
应用无人值守的GCxGC-TOFMS代谢组学表征南非结核病和2型糖尿病共病患者
Karla Reinecke,Léanie Kleynhans,Katharina Ronacher et al.
Karla Reinecke et al.
Introduction: Tuberculosis (TB) and type 2 diabetes mellitus (T2DM) are highly prevalent diseases resulting in high mortality rates globally. Furthermore, T2DM increases susceptibility to TB and vice versa, worsening dise...
NMR-based urinary biomarkers in pediatric primary mitochondrial disorders and chronic kidney disease: shared mitochondrial dysfunction, diverging biosignatures [0.03%]
基于尿液生物标志物的儿童原发性线粒体病和慢性肾脏疾病的核磁共振研究：共有的线粒体功能障碍，不同的生物签名
Margarida Paiva Coelho,João E Rodrigues,Teresa Costa et al.
Margarida Paiva Coelho et al.
Background: Renal involvement is a recognized feature of primary mitochondrial disorders (PMD), either at presentation or during the disease course. Simultaneously, the metabolomic fingerprint of chronic kidney disease (C...
Women in metabolomics [0.03%]
代谢组学研究中的女性科学家
Royston Goodacre
Royston Goodacre
Annelaure Damont,Anaïs Legrand,Kathleen Rousseau et al.
Annelaure Damont et al.
Introduction: Analysis of specific pathways of metabolic flux is usually achieved by administering stable isotope-labeled precursors and measuring their incorporation into selected metabolites by high-resolution mass spec...
Dried blood spots capture a wide range of metabolic pathways and biological changes associated with exercise [0.03%]
干燥血痕可捕获广泛的代谢途径和与运动相关的生物变化
Karen L DeBalsi,Kelli D Goodman,Laura J Sommerville et al.
Karen L DeBalsi et al.
Background: Metabolomics is poised to significantly advance our ability to diagnose and characterize disease, identify diagnostic and prognostic biomarkers, and monitor a patient's response to treatment. Despite these ben...
Evidence of cancer: a systematic review of metabolomics in extracellular vesicles for cancer biomarker detection [0.03%]
癌症的证据：外泌体代谢组学在癌症生物标志物检测中的系统性研究综述
Megan Mayhew,Oliver Megram,Simmie Roshan et al.
Megan Mayhew et al.
Background: The early detection of cancer remains a critical challenge in clinical oncology, with significant implications for patient survival rates and treatment outcomes. Research focus has shifted to developing minima...
In vitro production significantly reduces metabolic differences among bovine embryos [0.03%]
体外生产显著降低了牛胚胎之间的代谢差异
Denis Laloë,Julie Gatien,Camille Dupuy et al.
Denis Laloë et al.
Introduction: Although the in vitro production of bovine embryos now exceeds in vivo production, the quality of in vitro-produced embryos remains inferior. Metabolomic analysis of the spent culture medium used for embryos...
Lipidomic fingerprints reveal sex-, age-, and disease-dependent differences in the TgF344-AD transgenic rats [0.03%]
脂质组指纹揭示TgF344-AD转基因大鼠中性別、年龄和疾病依赖性的差异
Chunyuan Yin,Alida Kindt,Amy Harms et al.
Chunyuan Yin et al.
Background: Gathering information on Alzheimer's disease (AD) progression in human poses significant challenges due to the lengthy timelines and ethical considerations involved. Animal AD models provide a valuable alterna...