The functionality of the cysteinyl leukotriene receptor 1 (CysLTR1) in the lung by metabolomics analysis of bronchoalveolar lavage fluid [0.03%]
支气管肺泡灌洗液代谢组学分析揭示半胱氨酰白三烯受体1(CysLTR1)在肺中的功能
Wilson B Adeosun,Sibongiseni K L Poswayo,Suraj P Parihar et al.
Wilson B Adeosun et al.
Introduction: The cysteinyl leukotriene receptor 1 (CysLTR1) is known as a potent lipid mediator with a well-established role in inflammatory regulation and lung disease. While its involvement in immune cell recruitment h...
Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry metabolomic profiling reveals harvest age dependent changes in the roots of Pelargonium sidoides DC [0.03%]
超高效液相色谱-四极杆飞行时间质谱代谢组学揭示了收获年龄依赖性变化对Pelargonium sidoides DC根部的影响
Kundani Khameli,Muinat Nike Lewu,Takalani Mulaudzi et al.
Kundani Khameli et al.
Introduction: Cultivation of medicinal plants provides an opportunity for economic gain and health care accessibility. Ensuring consistent quality plant material is important for plants such as Pelargonium sidoides DC use...
Clinical lipidomics in bacterial sepsis: a systematic review of serum and plasma evaluations [0.03%]
细菌性感染症的临床脂质组学：血清和血浆评估的系统性回顾
Nurul Saadah Ahmad,Rosni Ibrahim,Toh Leong Tan et al.
Nurul Saadah Ahmad et al.
Background: Lipid metabolism plays a central role in host-pathogen interactions and immune regulation during bacterial sepsis, with its dysregulation contributing to organ failure and mortality. Blood-based lipidomics has...
Metabolic phenotypes of doxorubicin-induced cardiotoxicity among patients with breast cancer [0.03%]
乳腺癌患者多柔比星诱发的心脏毒性的代谢表型研究
Amarnath Singh,Se-Ran Jun,Katherine Wallis et al.
Amarnath Singh et al.
Background: Doxorubicin (DOX)-based chemotherapy has improved survival outcomes in breast cancer patients but is often limited by doxorubicin-induced cardiotoxicity (DIC). Currently, no validated biomarkers can predict ea...
Metabolomic signature reveals dysregulated lipoprotein profile in m.3243A>G carriers: a case-control study [0.03%]
代谢组学标志物显示m.3243A>G基因型携带者脂蛋白谱紊乱：一项病例对照研究
Simone Rask Nielsen,Hien Thi Thu Nguyen,Malene Pontoppidan Stoico et al.
Simone Rask Nielsen et al.
Introduction: The pathogenic mitochondrial gene variant m.3243A>G disrupts oxidative phosphorylation and is associated with insulin resistance, both of which may be linked to unfavorable lipid metabolism. However, the met...
Metabolomics in breast cancer: insights into treatment responses, disease progression, and prognostic assessment [0.03%]
代谢组学在乳腺癌中的应用：治疗反应、疾病进展和预后评估的见解
Dyah L Dewi,Elya Manik,Ema Damayanti et al.
Dyah L Dewi et al.
Background: Alterations in metabolic pathways are a hallmark of cancer and play a pivotal role in breast cancer development and progression. The inherent metabolic heterogeneity of breast cancer contributes to differences...
Exploratory NMR-based metabolomics reveals transient lipoprotein changes during prolonged computer gaming [0.03%]
基于NMR的代谢组学探索发现长时间电脑游戏期间脂蛋白的瞬时变化
Kasper Bygum Krarup,Henrik Bygum Krarup,Inge Søkilde Pedersen et al.
Kasper Bygum Krarup et al.
Introduction: Extended computer gaming is characterized by prolonged sedentary activity, disrupted sleep, emotional stress, and unrestricted intake of energy-dense foods and beverages. ...
LC-QQQ serum metabolomics reveals disease-specific metabolic signatures and diagnostic metabolite panels distinguishing polycythaemia vera from secondary polycythaemia [0.03%]
基于LC-QQQ的血清代谢组学研究揭示原发性红细胞增多症与继发性红细胞增多症的特异性代谢标志物及诊断标志物谱panels区分真性红细胞增多症和继发性红细胞增多症的疾病特异性代谢标志
Piotr Halicki,Patrycja Mojsak,Tomasz Pienkowski et al.
Piotr Halicki et al.
Background: Polycythaemia vera (PV) is a clonal myeloproliferative neoplasm driven by activating mutations in the JAK2 gene and is associated with an increased risk of thromboembolic events. Secondary polycythaemia (SP) c...
Anusha Ahlendorf,Asaph Aharoni,Khabat Vahabi et al.
Anusha Ahlendorf et al.
Introduction: The analysis of metabolic profiles using high resolution mass spectrometry (MS) data provides deep insights into biological processes. In metabolomics, MS analysis generates a large number of features that r...
Characterizing the effect of short wavelengths on the floral flavonoid metabolome of medicinal cannabis using a comparative computational metabolomics workflow [0.03%]
基于比较计算元组学的工作流程表征短波长对药用大麻花卉类黄酮元组的影响
Willy Contreras-Avilés,Laura Rosina Torres-Ortega,Ep Heuvelink et al.
Willy Contreras-Avilés et al.
Background: Controlled-environment cultivation of medicinal cannabis (Cannabis sativa L.) typically optimizes light conditions to enhance the biosynthesis of pharmaceutically important metabolites like cannabinoids. Such ...