Peptide Affinity Chromatography Applied to Therapeutic Antibodies Purification [0.03%]
多肽亲和层析在治疗性抗体纯化中的应用
Gabriela R Barredo-Vacchelli,Silvana L Giudicessi,María C Martínez-Ceron et al.
Gabriela R Barredo-Vacchelli et al.
The interest in therapeutic monoclonal antibodies (mAbs) has significantly grown in the pharmaceutical industry, exceeding 100 FDA mAbs approved. Although the upstream processing of their industrial production has been significantly improve...
Armamentarium of Cryoprotectants in Peptide Vaccines: Mechanistic Insight, Challenges, Opportunities and Future Prospects [0.03%]
肽疫苗中的冷冻保护剂的工具箱：机理洞察、挑战、机遇和未来展望
Harshita Dalvi,Aditi Bhat,Akshaya Iyer et al.
Harshita Dalvi et al.
Vaccines are designed to leverage the immune system and produce long-lasting protection against specific diseases. Peptide vaccines are regarded as safe and effective way of circumventing problems such as mild allergic reactions associated ...
Implementation of Vaccinomics and In-Silico Approaches to Construct Multimeric Based Vaccine Against Ovarian Cancer [0.03%]
疫苗组学和基于计算机模拟方法在卵巢癌多聚体疫苗构建中的实现
Muhammad Sufyan,Farah Shahid,Faiza Irshad et al.
Muhammad Sufyan et al.
One of the most common gynecologic cancers is ovarian cancer and ranked third after the other two most common cancers: cervical and uterine. The highest mortality rate has been observed in the case of ovarian cancer. To treat ovarian cancer...
Evaluation of Cell-Penetrating Peptides as Mucosal Immune Enhancers for Nasal Vaccination [0.03%]
细胞穿膜肽作为鼻用疫苗的粘膜免疫增强子的评估
Yadira Lobaina,Dioslaida Urquiza,Hilda Garay et al.
Yadira Lobaina et al.
Cell-penetrating peptides (CPPs) have been evaluated as enhancers in drug delivery, their addition in medical formulations favors drug absorption allowing obtaining the pharmacological effect with lower doses. In vaccine formulations their ...
Design of Monovalent and Chimeric Tetravalent Dengue Vaccine Using an Immunoinformatics Approach [0.03%]
使用免疫信息学方法设计单价和嵌合四价登革疫苗
Neeraj Kumar Dixit
Neeraj Kumar Dixit
An immunoinformatics technique was used to predict a monovalent amide immunogen candidate capable of producing therapeutic antibodies as well as a potent immunogen candidate capable of acting as a universal vaccination against all dengue fe...
Subtractive Proteomics and Immuno-informatics Approaches for Multi-peptide Vaccine Prediction Against Klebsiella oxytoca and Validation Through In Silico Expression [0.03%]
减法蛋白质组学和免疫信息学方法用于克雷伯氏氧土杆菌多肽疫苗预测及通过计算机模拟表达进行验证
Qudsia Yousafi,Humaira Amin,Shabana Bibi et al.
Qudsia Yousafi et al.
Klebsiella oxytoca is a gram-negative bacterium. It is opportunistic in nature and causes hospital acquired infections. Subtractive proteomics and reverse vaccinology approaches were employed to screen out the best proteins for vaccine desi...
A Comprehensive in Silico Analysis for Identification of Immunotherapeutic Epitopes of HPV-18 [0.03%]
人乳头瘤病毒18型免疫治疗表位的综合仿真分析
Bharti Gupta,Anoop Kumar,Parikipandla Sridevi
Bharti Gupta
Human papillomavirus (HPV) remains the major cause of cervical cancer, globally. High risk HPV (Hr-HPV) 16 and 18 together account for more than 70% of cervical cancer cases, whereas the hr-HPV-18 is the second most prevalent hr-HPV type, c...
Integrated Multi-omics, Virtual Screening and Molecular Docking Analysis of Methicillin-Resistant Staphylococcus aureus USA300 for the Identification of Potential Therapeutic Targets: An In-Silico Approach [0.03%]
甲氧西林耐药金黄色葡萄球菌USA300的综合多组学、虚拟筛选和分子对接分析以鉴定潜在治疗靶点的一种基于计算机的方法
Shakilur Rahman,Amit Kumar Das
Shakilur Rahman
Staphylococcus aureus infection is a leading cause of mortality and morbidity in community, hospital and live-stock sectors, especially with the widespread emergence of methicillin-resistant S. aureus (MRSA) strains. To identify new drug mo...
Viral 3CLpro as a Target for Antiviral Intervention Using Milk-Derived Bioactive Peptides [0.03%]
以病毒3CLpro为靶标使用乳源生物活性肽进行抗病毒干预
Yasaman Behzadipour,Maryam Gholampour,Somayeh Pirhadi et al.
Yasaman Behzadipour et al.
Viruses of the picornavirus-like supercluster mainly achieve cleavage of polyproteins into mature proteins through viral 3-chymotrypsin proteases (3Cpro) or 3-chymotrypsin-like proteases (3CLpro). Due to the essential role in processing vir...
Computational Design and Analysis of a Multi-epitope Against Influenza A virus [0.03%]
针对甲型流感病毒的多表位计算设计与分析
Samaneh Rostaminia,Seyed Soheil Aghaei,Behrokh Farahmand et al.
Samaneh Rostaminia et al.
Influenza A viruses are among the most studied viruses, however no effective prevention against influenza infection has been developed. So, designing an effective vaccine against Influenza A virus is a critical issue in the field of medical...