Molecular Chimera in Cancer Drug Discovery: Beyond Antibody Therapy, Designing Grafted Stable Peptides Targeting Cancer [0.03%]
癌症药物发现中的分子嵌合体：超越抗体疗法，设计嫁接的稳定肽以对抗癌症
Arpan Chowdhury,Prajesh Shrestha,Seetharama D Jois
Arpan Chowdhury
Background: Several cancer therapies are being developed, and given the variability of different cancer types, the goal of these therapies is to remove the invasive tumor from the body, kill the cancer cells, or else reta...
Isolation of Peptide Ligands for the HIV Capsid Protein p24 by Phage-Display [0.03%]
噬菌体展示技术用于HIV衣壳蛋白p24的肽配体分离
Jerry Woo,Emily Orozco,Srinivas S Thota et al.
Jerry Woo et al.
Purpose: Isolate renewable and cost-efficient affinity reagents that will facilitate the detection of p24, the capsid protein of Human Immunodeficiency Virus (HIV), by screening phage-displayed combinatorial peptide libra...
Synthetic studies of the mutant proinsulin syndrome demonstrate correlation between folding efficiency and age of diabetes onset [0.03%]
合成研究突变胰岛素原综合征发现折叠效率与糖尿病发病年龄相关性
Balamurugan Dhayalan,Yen-Shan Chen,Chun-Lun Ni et al.
Balamurugan Dhayalan et al.
Purpose: Heterozygous mutations in the insulin gene can give rise to a monogenic diabetes syndrome due to toxic misfolding of the variant proinsulin in the endoplasmic reticulum (ER) of pancreatic β-cells. Clinical mutat...
Alleviation of LPS-induced Endothelial Injury due to GHRH Antagonist Treatment [0.03%]
生长抑素作用下脂多糖诱导的内皮细胞损伤的缓解机制研究
Saikat Fakir,Khadeja-Tul Kubra,Mohammad Shohel Akhter et al.
Saikat Fakir et al.
Background: GHRH is produced in the hypothalamus and affects various tissues beyond the pituitary, including the lungs. GHRH antagonists exert anti-inflammatory properties in several experimental models of disease, but th...
Deferoxamine has the Potential to Improve the COVID-19-Related Inflammatory Response in Diabetic Patients [0.03%]
去铁敏有可能改善糖尿病患者的COVID-19相关炎症反应
Motahareh Zeinivand,Masoomeh Sharifi,Gholamhossein Hassanshahi et al.
Motahareh Zeinivand et al.
The clinical state of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been considered a pandemic disease (COVID-19) that is rapidly spreading worldwide. Despite all global efforts, the only treatment for COVID-19 is support...
Advances in Computational and Bioinformatics Tools and Databases for Designing and Developing a Multi-Epitope-Based Peptide Vaccine [0.03%]
用于设计和开发基于多表位的肽疫苗的计算和生物信息工具及数据库的研究进展
Mohammad Mahfuz Ali Khan Shawan,Ashish Ranjan Sharma,Sajal Kumar Halder et al.
Mohammad Mahfuz Ali Khan Shawan et al.
A vaccine is defined as a biologic preparation that trains the immune system, boosts immunity, and protects against a deadly microbial infection. They have been used for centuries to combat a variety of contagious illnesses by means of subs...
Strategic Approaches to Improvise Peptide Drugs as Next Generation Therapeutics [0.03%]
肽药物的即兴策略作为下一代治疗方案
Panchali Barman,Shubhi Joshi,Sheetal Sharma et al.
Panchali Barman et al.
In recent years, the occurrence of a wide variety of drug-resistant diseases has led to an increase in interest in alternate therapies. Peptide-based drugs as an alternate therapy hold researchers' attention in various therapeutic fields su...
Analysis of the Differential Expression and Antiviral Activity of Porcine Interferon-α In Vitro [0.03%]
猪 interferon-α 的差异表达及其体外抗病毒活性分析
Jianyu Fang,Qingxian Zhang,Yanyan Xi et al.
Jianyu Fang et al.
Porcine interferon α (poIFN-α) is a crucial cytokine that can prevent and treat viral infections. Seventeen functional porcine IFN-α subtypes were found in the porcine genome. In this study, multiple sequence alignment was performed to a...
Ahmed Hussain,Shashwati Ghosh Sachan
Ahmed Hussain
Microbes are helpful and destructive to human health and other living organisms. Microbes can be eliminated by using antibiotics against them, but their capability to resist regularly encountering antibiotics makes them more injurious. Micr...
Recombinant Insulin-Like Growth Factor 1 Dimers: Receptor Binding Affinities and Activation Abilities [0.03%]
重组胰岛素样生长因子1二聚体：受体结合亲和力及激活能力
Jingjing Lin,Seiya Asai,Irena Selicharová et al.
Jingjing Lin et al.
Insulin-like growth factor 1 (IGF-1) and its IGF-1 receptor (IGF-1R) belong to an important biological system that is involved in the regulation of normal growth, but that has also been recognized as playing a role in cancer. IGF-1R antagon...