Immunoinformatics Approach to Design a Novel Subunit Vaccine Against Visceral Leishmaniasis [0.03%]
免疫信息学在设计新的子单位利什曼病疫苗中的应用
Alireza Lari,Niloofar Lari,Atefeh Biabangard
Alireza Lari
Visceral leishmaniasis (VL) infection is mostly caused by Leishmania donovani and affects countries worldwide. Despite the need for a safe and effective vaccine against leishmaniasis due to the increased drug resistance, however, no vaccine...
Pierce into Structural Changes of Interactions Between Mutated Spike Glycoproteins and ACE2 to Evaluate Its Potential Biological and Therapeutic Consequences [0.03%]
探究突变的刺突糖蛋白与ACE2相互作用的结构变化及其潜在的生物学和治疗学后果
Zahra Sadat Hashemi,Mahboubeh Zarei,Shaden M H Mubarak et al.
Zahra Sadat Hashemi et al.
The structural consequences of ongoing mutations on the SARS-CoV-2 spike-protein remains to be fully elucidated. These mutations could change the binding affinity between the virus and its target cell. Moreover, obtaining new mutations woul...
In-Silico Design of a Novel Tridecapeptide Targeting Spike Protein of SARS-CoV-2 Variants of Concern [0.03%]
针对SARS-CoV-2关切变异株刺突蛋白的新型十三肽药物的计算机辅助设计
Sajjan Rajpoot,Kundan Solanki,Ashutosh Kumar et al.
Sajjan Rajpoot et al.
Several mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have increased the transmission and mortality rate of coronavirus disease-19 (COVID-19) across the globe. Although many vaccines have been developed, a large ...
In Silico Analysis of Inhibiting Papain-like Protease from SARS-CoV-2 by Using Plant-Derived Peptides [0.03%]
基于植物源多肽的SARS-CoV-2蛋白酶抑制作用的计算机模拟分析研究
Mohammad Moradi,Reza Golmohammadi,Ali Najafi et al.
Mohammad Moradi et al.
SARS-CoV-2 is a corona virus that has been the cause for one of the deadliest pandemics of history, started since 2019. Suppressing the activity of the critical enzymes in the SARS-CoV-2 could potentially inhibit a vital step in viral life ...
Head and Neck Squamous Cell Carcinoma: Risk Factors, Molecular Alterations, Immunology and Peptide Vaccines [0.03%]
头颈部鳞状细胞癌：危险因素、分子改变、免疫学及肽疫苗
Zhe Sun,Xiaodong Sun,Zhanwei Chen et al.
Zhe Sun et al.
Head and neck squamous cell carcinoma (HNSCC) arises from the epithelial lining of the oral cavity, hypopharynx, oropharynx, and larynx. There are several potential risk factors that cause the generation of HNSCC, including cigarette smokin...
In-Silico Vaccine Design Based on a Novel Vaccine Candidate Against Infections Caused by Acinetobacter baumannii [0.03%]
基于新型疫苗候选物质的鲍曼不动杆菌感染疫苗的计算机辅助设计
Kashaf Khalid,Sidra Irum,Sidra Rahmat Ullah et al.
Kashaf Khalid et al.
Acinetobacter baumannii is notorious for causing serious infections of the skin, lungs, soft tissues, bloodstream, and urinary tract. Despite the overwhelming information available so far, there has still been no approved vaccine in the mar...
In-Silico Validation of Prosopis ciniraria Therapeutic Peptides Against Fungal Cell Wall: Better Treatment Strategy for Fungal Diseases [0.03%]
Prosopis ciniraria治疗真菌细胞壁的 therapeutic肽的仿真验证：更好的治疗真菌疾病的策略
Amit Joshi,Dilip Singh Solanki,Praveen Gehlot et al.
Amit Joshi et al.
Prosopis cineraria commonly known as Druce are valuable herb that holds antibacterial role, antifungal properties. We identified different peptides from this plant by deploying CADD (Computer-aided-drug-designing) approaches, these peptide ...
l-asparaginase: Need for an Expedition from an Enzymatic Molecule to Antimicrobial Drug [0.03%]
L-天冬酰胺酶：从酶分子到抗菌药物的探索需求
Archana Vimal,Awanish Kumar
Archana Vimal
Enzymes play a vital role in the biological system as a catalyst for biochemical reactions. They have a wide range of commercial applications in many areas like the pharmaceutical industry, food industry, etc. l-asparaginase is one of the c...
Aleksei Kuznetsov,Piret Arukuusk,Heleri Härk et al.
Aleksei Kuznetsov et al.
We study the effect of the peptide QAKTFLDKFNHEAEDLFYQ on the kinetics of the SARS-CoV-2 spike protein S1 binding to angiotensin-converting enzyme 2 (ACE2), with the aim to characterize the interaction mechanism of the SARS-CoV2 virus with ...
Evaluation and Designing of Epitopic-Peptide Vaccine Against Bunyamwera orthobunyavirus Using M-Polyprotein Target Sequences [0.03%]
使用M-多聚蛋白靶序列对Bunyamwera正布尼亚病毒的表位肽疫苗进行评估与设计
Pratik Ghosh,Manojit Bhattacharya,Prasanta Patra et al.
Pratik Ghosh et al.
Bunyamwera orthobunyavirus and its serogroup can cause several diseases in humans, cattle, ruminants, and birds. The viral M-polyprotein helps the virus to enter the host body. Therefore, this protein might serve as a potential vaccine targ...