Immunogenic Epitope-Based Vaccine Prediction from Surface Glycoprotein of MERS-CoV by Deploying Immunoinformatics Approach [0.03%]
基于免疫信息学方法的MERS-CoV表面糖蛋白免疫原性表位疫苗的设计预测
Truc Ly Nguyen,Youngho Lee,Heebal Kim
Truc Ly Nguyen
Middle East respiratory syndrome coronavirus (MERS-CoV) has caused a high mortality rate since its emergence in 2012 in the Middle East. Currently, no effective drug or vaccine is available for MERS-CoV. Supportive care and prevention are t...
A Novel Multiepitope Vaccine Against Bladder Cancer Based on CTL and HTL Epitopes for Induction of Strong Immune Using Immunoinformatics Approaches [0.03%]
基于免疫信息学方法的诱导强力免疫的新型多抗原表位膀胱癌疫苗设计：以CTL和HTL表位为基础
Ehsan Jahangirian,Ghadir A Jamal,MohammadReza Nouroozi et al.
Ehsan Jahangirian et al.
Bladder cancer is well-known cancer in two forms of muscle-invasive and non-muscle-invasive bladder cancer which is responsible for annual deaths worldwide. Common therapies methods are somewhat successful; however, these methods have the l...
Role of Polypeptide Inflammatory Biomarkers in the Diagnosis and Monitoring of COVID-19 [0.03%]
肽类炎症生物标志物在COVID-19诊断和监测中的作用
Aparajita Sen,Arti Nigam,Meenakshi Vachher
Aparajita Sen
The COVID-19 (coronavirus disease 2019) pandemic that took over the world in December 2019 has had everlasting devastating impacts on the lives of people globally. It manifests a huge symptom spectrum ranging from asymptomatic to critically...
Exploring Structural Mechanism of COVID-19 Treatment with Glutathione as a Potential Peptide Inhibitor to the Main Protease: Molecular Dynamics Simulation and MM/PBSA Free Energy Calculations Study [0.03%]
基于分子动力学模拟和MM/PBSA自由能计算的探究：谷胱甘肽作为治疗COVID-19的主蛋白酶潜在肽类抑制剂的结构机制研究
Abderahmane Linani,Khedidja Benarous,Leila Bou-Salah et al.
Abderahmane Linani et al.
The 2019-novel coronavirus has unfolded everywhere in the world and obliged a billion human beings in open confinement, whereas many treatments, and vaccines have been proposed towards this pandemic. The main protease (Mpro) is an attractiv...
Chikungunya Virus Vaccine Development: Through Computational Proteome Exploration for Finding of HLA and cTAP Binding Novel Epitopes as Vaccine Candidates [0.03%]
基孔肯雅病毒疫苗研发：通过计算蛋白质组学探索寻找HLA和cTAP结合的新表位作为候选疫苗
Priti Sharma,Pawan Sharma,Sheeba Ahmad et al.
Priti Sharma et al.
Chikungunya virus is a major arbovirus of great public health concern in the whole world, but no vaccine is yet available, still advance therapeutic treatment and effective vaccines are in progress. The present multistep screening and struc...
Molecular Characterization and Designing of a Novel Multiepitope Vaccine Construct Against Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌多表位疫苗的分子设计及特征分析研究
Jyotirmayee Dey,Soumya Ranjan Mahapatra,Sibabratta Patnaik et al.
Jyotirmayee Dey et al.
Abstract: Pseudomonas aeruginosa, an ESKAPE pathogen causes many fatal clinical diseases in humans across the globe. Despite an increase in clinical instances of Pseudomonas infection, there is currently no effective vacc...
Protective Effects of Phoenixin-14 Peptide in the Indomethacin-Induced Duodenal Ulcer: An Experimental Study [0.03%]
凤凰宁14肽对吲哚美辛致十二指肠溃疡的保护作用研究
Yaser Zandeh-Rahimi,Negar Panahi,Saeed Hesaraki et al.
Yaser Zandeh-Rahimi et al.
Phoenixin-14 (PNX-14) is a newly identified neuropeptide with potential anti-inflammatory effects in the gastrointestinal tract. In this study, we evaluated the protective effect of PNX-14 against the formation of experimental indomet...
Viral Prefusion Targeting Using Entry Inhibitor Peptides: The Case of SARS-CoV-2 and Influenza A virus [0.03%]
利用进入抑制肽针对病毒融合前状态的研究：以SARS-CoV-2和甲型流感病毒为例
Yasaman Behzadipour,Shiva Hemmati
Yasaman Behzadipour
In this study, peptide entry inhibitors against the fusion processes of severe acute respiratory syndrome coronavirus-2 (SCV2) and influenza A virus (IAV) were designed and evaluated. Fusion inhibitor peptides targeting the conformational s...
In silico Design and Characterization of Multi-epitopes Vaccine for SARS-CoV2 from Its Spike Protein [0.03%]
基于SARS-CoV2的刺突蛋白的多表位疫苗的计算机设计与鉴定
Gunderao H Kathwate
Gunderao H Kathwate
COVID 19 is a disease caused by a novel coronavirus, SARS-CoV2 originated in China most probably of Bat origin. Multiepitopes vaccine would be useful in eliminating SARS-CoV2 infections as asymptomatic patients are in large numbers. In resp...
VirVACPRED: A Web Server for Prediction of Protective Viral Antigens [0.03%]
VirVACPRED：一个用于预测保护性病毒抗原的网络服务器
Jesús Herrera-Bravo,Jorge G Farías,Fernanda Parraguez Contreras et al.
Jesús Herrera-Bravo et al.
Viral antigens are key in the development of vaccines that prevent or eradicate infections caused by these pathogens. Bioinformatics tools are modern alternatives that facilitate the discovery of viral antigens, reducing the costs of experi...