Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53-HDM2 Protein-Protein Interaction [0.03%]
p53-HDM2蛋白-蛋白相互作用的肽、拟肽和小分子拮抗剂
Peter M Fischer
Peter M Fischer
Modulation of intracellular protein-protein interactions has been - and remains - a challenging goal for the discovery and development of small-molecule therapeutic agents. Progress in the pharmacological targeting and understanding at the ...
Peptide and Peptide-Like Modulators of 20S Proteasome Enzymatic Activity in Cancer Cells [0.03%]
用于调节癌细胞中20S蛋白酶体酶活性的肽和类肽调控剂
Carlos García-Echeverría
Carlos García-Echeverría
The involvement of the ubiquitin-proteasome pathway in the degradation of critical intracellular regulatory proteins suggested a few years ago the potential use of proteasome inhibitors as novel therapeutic agents being applicable in many d...
Protein Kinase C Regulates the Cell Surface Activity of Endothelin-Converting Enzyme-1 [0.03%]
蛋白激酶C调控内皮素转化酶-1的细胞表面活性
A Ian Smith,Rebecca A Lew,Walter G Thomas et al.
A Ian Smith et al.
The potent vasoconstrictor endothelin is a 21 amino acid peptide whose principal physiological function is to regulate vascular tone. The generation of endothelin is crucially dependent on the local presence and activity of endothelin conve...
Sushil K Sharma,Christopher Straub,Leigh Zawel
Sushil K Sharma
Inhibitor of apoptosis proteins (IAPs) such as XIAP subvert apoptosis by binding and inhibiting caspases. Because occupation of the XIAP BIR3 peptide binding pocket by Smac abolishes the XIAP-caspase 9 interaction, it is a proapoptotic even...
The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs [0.03%]
利用噬菌体肽展示技术开发靶向肿瘤的药物
Lauren R H Krumpe,Toshiyuki Mori
Lauren R H Krumpe
Monoclonal antibodies have been successfully utilized as cancer-targeting therapeutics and diagnostics, but the efficacies of these treatments are limited in part by the size of the molecules and non-specific uptake by the reticuloendotheli...
Development of Grb2 SH2 Domain Signaling Antagonists: A Potential New Class of Antiproliferative Agents [0.03%]
Grb2 SH2结构域信号拮抗剂的开发——一类新的抗增殖剂
Terrence R Burke
Terrence R Burke
Aberrant signaling through protein-tyrosine kinase (PTK)-dependent pathways is associated with several proliferative diseases. Accordingly, PTK inhibitors are being developed as new approaches for the treatment of certain cancers. Growth fa...