Making Ends Meet: Microwave-Accelerated Synthesis of Cyclic and Disulfide Rich Proteins Via In Situ Thioesterification and Native Chemical Ligation [0.03%]
化繁为简——通过原位硫酯化及原位化学肽键形成反应合成高张力环状和二硫丰富的多肽蛋白质的研究
Sunithi Gunasekera,Teshome L Aboye,Walid A Madian et al.
Sunithi Gunasekera et al.
The development of synthetic methodologies for cyclic peptides is driven by the discovery of cyclic peptide drug scaffolds such as the plant-derived cyclotides, sunflower trypsin inhibitor 1 (SFTI-1) and the development of cyclized conotoxi...
Anticancer activity of proapoptotic peptides is highly improved by thermal targeting using elastin-like polypeptides [0.03%]
热致靶向弹性聚肽增强抗肿瘤活性研究
Shama Moktan,Drazen Raucher
Shama Moktan
Inducing apoptosis in cancer cells is an effective strategy for cancer therapy. The cationic α-helix forming KLAKLAKKLAKLAK peptide (KLAK) has been known to induce apoptosis by disrupting the mitochondria. In the present study, we have des...
Novel Detox Gel Depot sequesters β-Amyloid Peptides in a mouse model of Alzheimer's Disease [0.03%]
一种新型的排毒凝胶位点可清除阿尔茨海默病小鼠模型中的β-淀粉样蛋白肽
Ranjini K Sundaram,Chinnaswamy Kasinathan,Stanley Stein et al.
Ranjini K Sundaram et al.
Alzheimer's Disease (AD), a debilitating neurodegenerative disease is caused by aggregation and accumulation of a 39-43 amino acid peptide (amyloid β or Aβ) in brain parenchyma and cerebrovasculature. The rational approach would be to use...
Improving the Fmoc Solid Phase Synthesis of the Cyclic Hexapeptide Complement C5a Antagonist, PMX205 [0.03%]
改进固相合成环肽PMX205（补体C5a拮抗剂）中Fmoc策略的研究
R C Delisle Milton,S C Milton,A R Chamberlin
R C Delisle Milton
The anti-inflammatory drug, PMX205, is an antagonist of the C5a complement receptor and has been shown to be effective in rodent models of amyotrophic lateral sclerosis and Alzheimer's disease. This cyclic hexapeptide (c[Arg-Trp-D-Cha-Pro-O...
Novel Bradykinin Analogues Modified in the N-Terminal Part of the Molecule with a Variety of Acyl Substituents [0.03%]
分子氮端部分具有各种酰基取代物的新型缓激肽类似物
Małgorzata Sleszyńska,Tomasz H Wierzba,Krzysztof Malinowski et al.
Małgorzata Sleszyńska et al.
In the current work we present some pharmacological characteristics of ten new analogues of bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) modified in the N-terminal part of the molecule with a variety of acyl substituents. Of the many ac...
Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities [0.03%]
用于治疗的抗菌多价肽设计原理和结构多样性
S P Liu,L Zhou,R Lakshminarayanan et al.
S P Liu et al.
This review highlights the design principles, progress and advantages attributed to the structural diversity associated with both natural and synthetic multivalent antimicrobial peptides (AMPs). Natural homo- or hetero-dimers of AMPs linked...
Anti-Tumoral Activity of a Short Decapeptide Fragment of the Alzheimer's Abeta Peptide [0.03%]
阿耳茨海默病Abeta肽的一个短十肽片段的抗肿瘤活性
Daniel Paris,Nikunj Patel,Nowell J Ganey et al.
Daniel Paris et al.
The inhibition of angiogenesis is regarded as a promising avenue for cancer treatment. Although some antiangiogenic compounds are in the process of development and testing, these often prove ineffective in vivo, therefore the search for new...
A Simple & Convenient Solid Phase Synthesis of Bacterial Origin Octapeptide Sequence, Glu-Asp-Gly-Asn-Lys-Pro-Gly-Lys-OH [0.03%]
一个简单便捷的固相合成细菌来源八肽序列GlodesgnlkpgkrOH的方法
Riaz A Khan
Riaz A Khan
The repeating octapeptide sequence, Glu-Asp-Gly-Asn-Lys-Pro-Gly-Lys-OH derived from the glycoprotein found in Staphylococcus aureus cell wall is assembled by simple solid phase peptide synthesis methodology using a base labile linker.
Solid Phase Synthesis and Application of Labeled Peptide Derivatives: Probes of Receptor-Opioid Peptide Interactions [0.03%]
固相合成及标记肽衍生物的应用：受体-内啡肽类似物相互作用的探针研究
Jane V Aldrich,Vivek Kumar,Bhaswati Dattachowdhury et al.
Jane V Aldrich et al.
Solid phase synthetic methodology has been developed in our laboratory to incorporate an affinity label (a reactive functionality such as isothiocyanate or bromoacetamide) into peptides (Leelasvatanakij, L. and Aldrich, J. V. (2000) J. Pept...
Solid-Phase Synthesis of Heterobivalent Ligands Targeted to Melanocortin and Cholecystokinin Receptors [0.03%]
针对黑素皮质激素和胆囊收缩素受体的杂双价配体固相合成法
Jatinder S Josan,Josef Vagner,Heather L Handl et al.
Jatinder S Josan et al.
Heteromultivalency provides a route to increase binding avidity and to high specificity when compared to monovalent ligands. The enhanced specificity can potentially serve as a unique platform to develop diagnostics and therapeutics. To dev...