Influence of Dimerization of Lipopeptide Laur-Orn-Orn-Cys-NH2 and an N-terminal Peptide of Human Lactoferricin on Biological Activity [0.03%]
两性肽单元二聚化对生物活性的影响研究——以环状脂肽十二烷基-L-正亮-L-鸟-L-半胱氨酰胺和人乳铁蛋白N末端短肽为例
Elżbieta Kamysz,Emilia Sikorska,Małgorzata Dawgul et al.
Elżbieta Kamysz et al.
Lactoferrin (LF) is a naturally occurring antimicrobial peptide that is cleaved by pepsin to lactoferricin (LFcin). LFcin has an enhanced antimicrobial activity as compared to that of LF. Recently several hetero- and homodimeric antimicrobi...
Biochemical and Cellular Specificity of Peptide Inhibitors of G Protein-Coupled Receptor Kinases [0.03%]
G蛋白偶联受体激酶肽抑制剂的生化和细胞特异性
Faiza Baameur,Richard A Hammitt,Jacqueline Friedman et al.
Faiza Baameur et al.
Identifying novel allosteric inhibitors of G protein-coupled receptor kinases (GRKs) would be of considerable use in limiting both the extent of desensitization of GPCRs as well as downstream positive regulation through GRKs. Several peptid...
A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection at the Level of Cell Entry [0.03%]
一种新的抗人Radixin肽通过作用于细胞进入水平抑制丙型肝炎病毒感染
Terence N Bukong,Karen Kodys,Gyongyi Szabo
Terence N Bukong
Hepatitis C virus infection of hepatocytes is a multistep process involving the interaction between viral and host cell molecules. Recently, we identified ezrin-moesin-radixin proteins and spleen tyrosine kinase (SYK) as important host ther...
The Evaluation of Dipeptidyl Peptidase (DPP)-IV, α-Glucosidase and Angiotensin Converting Enzyme (ACE) Inhibitory Activities of Whey Proteins Hydrolyzed with Serine Protease Isolated from Asian Pumpkin (Cucurbita ficifolia) [0.03%]
亚洲南瓜丝氨酸蛋白酶降解乳清蛋白的DPP-IV、α-糖苷酶和血管紧张素转换酶（ACE）抑制活性评价
Babij Konrad,Dąbrowska Anna,Szołtysik Marek et al.
Babij Konrad et al.
In the present study, whey protein concentrate (WPC-80) and β-lactoglobulin were hydrolyzed with a noncommercial serine protease isolated from Asian pumpkin (Cucurbita ficifolia). Hydrolysates were further fractionated by ultrafiltration u...
Structure-Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3) [0.03%]
靶向信号转导及转录激活因子3的Src同源序列2结构域的磷肽模拟前药的构效关系研究
Pijus K Mandal,Zhiyong Ren,Xiaomin Chen et al.
Pijus K Mandal et al.
Signal transducer and activator of transcription 3 (Stat3) transmits signals from growth factors and interleukin-6 family cytokines by binding to their receptors via its Src homology 2 (SH2) domain. This results in phosphorylation of Tyr705...
Synthesis of Fmoc-Gly-Ile Phosphinic Pseudodipeptide: Residue Specific Conditions for Construction of Matrix Metalloproteinase Inhibitor Building Blocks [0.03%]
芴甲氧羰酰甘氨酰异亮磷肽的合成：基质金属蛋白酶抑制剂构建模块反应条件的位点特异性研究
Manishabrata Bhowmick,Gregg B Fields
Manishabrata Bhowmick
The efficient synthesis of an Fmoc-Gly-Ile phosphinic pseudodipeptide was desired as an eventual building block for construction of matrix metalloproteinase inhibitors. A Michael-type addition reaction of bis(tri-methylsilyl) phosphonite wi...
Age-Related Changes in the Mechanical Properties of Human Fibroblasts and Its Prospective Reversal After Anti-Wrinkle Tripeptide Treatment [0.03%]
人类成纤维细胞的机械性能老化变化及其在抗皱三肽治疗后的逆转研究
Ida Dulińska-Molak,Monika Pasikowska,Katarzyna Pogoda et al.
Ida Dulińska-Molak et al.
One of an essential characteristic of human skin are time dependent mechanical properties. Here, we demonstrate that stiffness of human dermal fibroblast correlates with age and it can be restored after anti-wrinkle tripeptide treatment. Th...
Yi Kong,Yu Shao,Hao Chen et al.
Yi Kong et al.
Centipedes have been used as traditional medicine for thousands of years in China. Centipede venoms consist of many biochemical peptides and proteins. Factor Xa (FXa) is a serine endopeptidase that plays the key role in blood coagulation, a...
Determination of Hexapeptide ALA-ASP-LEU-LYS-PRO-THR by MALDI MS [0.03%]
MALDI质谱法测定六肽ALA-ASP-LEU-LYS-PRO-THR
Anna Olejnik,Izabela Nowak,Krystian Eitner et al.
Anna Olejnik et al.
The hexapeptide ALA-ASP-LEU-LYS-PRO-THR is currently widely used as an active ingredient in commercially available creams. Therefore, the proper analytical procedure to detect this compound is a very important issue. This paper presents the...
Synthesis and Biological Activity of N-Sulfonyltripeptides with C-Terminal Arginine as Potential Serine Proteases Inhibitors [0.03%]
具有C末端精氨酸的N-磺酰基三肽的合成及其作为丝氨酸蛋白酶抑制剂的活性研究
Agnieszka Markowska,Magdalena Bruzgo,Ewa Gorodkiewicz et al.
Agnieszka Markowska et al.
Tripeptides of the general X-SO2-d-Ser-AA-Arg-CO-Y formula, where X = α-tolyl, p-tolyl, 2,4,6-triisopropylphenyl; AA = alanine, glycine, norvaline and Y = OH, NH-(CH2)5NH2 were obtained and tested for their effect on the amidolytic activit...