Modulation of Oral Bioavailability and Metabolism for Closely Related Cyclic Hexapeptides [0.03%]
调控环形六肽类似物的口服吸收和代谢研究
Thomas Vorherr,Ian Lewis,Joerg Berghausen et al.
Thomas Vorherr et al.
Abstract: Recently, a variety of studies concerned with the permeability and oral bioavailability of cyclic peptides have been reported. In particular, strategies aiming at modifying peptides to maintain or to enhance sol...
The Analysis of Cu(II)/Zn(II) Cyclopeptide System as Potential Cu,ZnSOD Mimic Center [0.03%]
作为Cu,ZnSOD模拟催化中心的Cu(II)/Zn(II)环肽体系的理论研究
Aleksandra Kotynia,Tomasz Janek,Żaneta Czyżnikowska et al.
Aleksandra Kotynia et al.
In this paper are presented the features of copper (II) and zinc (II) heteronuclear complexes of the cyclic peptide-c(HKHGPG)2. The coordination properties of ligand were studied by potentiometric, UV-Vis and CD spectroscopic methods. These...
The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding [0.03%]
三种新型唾液肽类似物的协调能力：结构修饰对铜结合的影响
Aleksandra Kotynia,Edward Krzyżak,Elżbieta Kamysz et al.
Aleksandra Kotynia et al.
Three novel analogues of salivary peptides as sialorphin (QHNPR) and opiorphin (QRFSR) were synthesized by the solid-phase method. The sequences of these ligands were following: AHNPR, QANPR and QRFPR. The aim of our work was investigation ...
Nebulized Delivery of the MAPKAP Kinase 2 Peptide Inhibitor MMI-0100 Protects Against Ischemia-Induced Systolic Dysfunction [0.03%]
MAPKAP 蛋白激酶 2 抑制剂肽 MMI-0100 雾化给药可预防缺血引起的收缩功能障碍
David I Brown,Brian C Cooley,Megan T Quintana et al.
David I Brown et al.
Acute myocardial infarction (AMI) results in systolic dysfunction, myocarditis and fibrotic remodeling, which causes irreversible pathological remodeling of the heart. Associated cell death and inflammation cause cytokine release, which act...
Peptides with 6-Aminohexanoic Acid: Synthesis and Evaluation as Plasmin Inhibitors [0.03%]
含有6-氨基己酸肽的合成及纤溶酶抑制剂活性评估
Maciej Purwin,Agnieszka Markowska,Irena Bruzgo et al.
Maciej Purwin et al.
Fifteen new peptide derivatives of ɛ-aminocaproic acid (EACA) containing the known fragment -Ala-Phe-Lys- with an affinity for plasmin were synthesised in the present study. The synthesis was carried out a solid phase. The following compou...
Aleksandra Marciniak,Marek Cebrat,Justyna Brasuń
Aleksandra Marciniak
Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abil...
Iwona M Rybakowska,Stanisław Bakuła,Krystian Kaletha
Iwona M Rybakowska
Similar symptoms observed in Myasthenia gravis (MG) can be also detected in the case of skeletal muscle AMP-deaminase deficiency. We compared the activity and expression of AMP-deaminase (AMPD) products in skeletal muscles of MG patients an...
Maciej Jaskiewicz,Malgorzata Orlowska,Gabriela Olizarowicz et al.
Maciej Jaskiewicz et al.
Increasing resistance to conventional antibiotics among microorganisms is one of the leading problems of medicine nowadays. Antimicrobial peptides are compounds exhibiting both antibacterial and antifungal activities. However, it is difficu...
Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation [0.03%]
S-烷基化获得的p53依赖型癌症治疗的桥联类似物
Ewa D Micewicz,Shantanu Sharma,Alan J Waring et al.
Ewa D Micewicz et al.
A small library of anticancer, cell-permeating, stapled peptides based on potent dual-specific antagonist of p53-MDM2/MDMX interactions, PMI-N8A, was synthesized, characterized and screened for anticancer activity against human colorectal c...
Multiple Bacteriophage Selection Strategies for Improved Affinity of a Peptide Targeting ERBB2 [0.03%]
用于提高靶向ERBB2肽亲和力的多种噬菌体选择策略
Benjamin M Larimer,Jeanne M Quinn,Kevin Kramer et al.
Benjamin M Larimer et al.
Due to the heterogeneity of ERBB2-expression between tumors and over the course of treatment, a non-invasive molecular imaging agent is needed to accurately detect overall ERBB2 status. Peptides are a highly advantageous platform for molecu...