Biological Properties, Current Applications and Potential Therapeautic Applications of Brevinin Peptide Superfamily [0.03%]
brevinin多肽家族的生物学特性、现有应用及潜在治疗价值
Fatemeh Zohrab,Saeedeh Askarian,Amin Jalili et al.
Fatemeh Zohrab et al.
The Brevinin peptides are antimicrobial agents obtained from frog skin secretions. Brevinin-2R has attracted many attentions due to its very low hemolytic activity, cationic property, and high affinity to cancer cells. Moreover, it has show...
Arijit Ghosh,Rini Roy,Monoswini Nandi et al.
Arijit Ghosh et al.
Scorpion venom components have multifaceted orientation against bacterial, viral, fungal infections and other neuronal disorders. They can modulate the ion channels (K+, Na+, Cl-, Ca2+) of our body and this concept has been hypothesized in ...
Aaliya Shah,Bilqees Bano
Aaliya Shah
The Cystatins constitute a large group of evolutionary related proteins with diverse biological activities. They have been recently realized as instrumental in myriad of pathophysiological conditions. They have been implicated in various pa...
Solid Phase Synthesis of Dual Labeled Peptides: Development of Cell Permeable Calpain Specific Substrates [0.03%]
固相合成双重标记肽：细胞渗透型钙蛋白特异性底物的开发
Brian M Polster,Rafael Arze,Matthew H Lyttle et al.
Brian M Polster et al.
A step-by-step evaluation of dual-labeled FRET substrates for the protease calpain is reported. The study led to cell permeable selections, with optimized specificity and effectiveness for the target enzyme, and improved stability to non-sp...
Insilico Alpha-Helical Structural Recognition of Temporin Antimicrobial Peptides and Its Interactions with Middle East Respiratory Syndrome-Coronavirus [0.03%]
时空肺炎链球菌抗菌肽的α-螺旋构象及其与中东呼吸综合征冠状病毒的相互作用
Sathish Kumar Marimuthu,Krishnanand Nagarajan,Sathish Kumar Perumal et al.
Sathish Kumar Marimuthu et al.
Many antimicrobial peptides (AMPs) have multiple antimicrobial immunity effects. One such class of peptides is temporins. Temporins are the smallest (AMPs) found in nature and are highly active against gram-positive bacteria. Nowadays, ther...
The Effect of Anti-aging Peptides on Mechanical and Biological Properties of HaCaT Keratinocytes [0.03%]
抗衰老肽对HaCaT角质细胞力学性能及生物学行为的影响
Tomasz Kobiela,Małgorzata Milner-Krawczyk,Monika Pasikowska-Piwko et al.
Tomasz Kobiela et al.
Atomic force microscopy (AFM) and fluorescence microscopy was applied to determine the influence of the anti-aging peptides on the morphology and the mechanical properties of keratinocytes. Immortalized human keratinocytes (HaCaT) were trea...
Apoptotic Effect of Melittin Purified from Iranian Honey Bee Venom on Human Cervical Cancer HeLa Cell Line [0.03%]
从伊朗蜜蜂毒液中分离出来的蜂毒素对人宫颈癌HeLa细胞系的凋亡效应
Hannaneh Zarrinnahad,Amir Mahmoodzadeh,Monireh Parviz Hamidi et al.
Hannaneh Zarrinnahad et al.
Melittin, an amphipathic 26-residue peptide, is the main component of honey bee venom. Studies have been demonstrated that melittin has an inhibitory effect on proliferation of cancer cells. However, the precise mechanism of action is not c...
A Tetra-Orthogonal Strategy for the Efficient Synthesis of Scaffolds Based on Cyclic Peptides [0.03%]
基于环肽的高效合成骨架的四正交策略
Nitin Jain,Simon H Friedman
Nitin Jain
We have developed a straightforward and robust strategy for synthesizing a family of cyclic peptide scaffolds for the presentation of defined moieties in a wide range of orientations. Specifically we are exploring quinoxaline as the moiety,...
Lijing Hao,Di Wen,Hongyan Gou et al.
Lijing Hao et al.
Studies demonstrated that cholecystokinin (CCK) system involved in morphine dependence and withdrawal. Our previous study showed that endogenous CCK system were up-regulated after chronic morphine exposure. Additionally, CCK1 receptor signi...
Citropin 1.1 Trifluoroacetate to Chloride Counter-Ion Exchange in HCl-Saturated Organic Solutions: An Alternative Approach [0.03%]
由盐酸饱和的有机溶液介导的citropin 1.1 trifluoroacetate的 trifluoroacetate到氯离子的 counter-ion交换：一种替代方法
Karol Sikora,Damian Neubauer,Maciej Jaśkiewicz et al.
Karol Sikora et al.
In view of the increasing interest in peptides in various market sectors, a stronger emphasis on topics related to their production has been seen. Fmoc-based solid phase peptide synthesis, although being fast and efficient, provides final p...