Garima Agarwal,Reema Gabrani
Garima Agarwal
Despite rapid advances in the human healthcare, the infection caused by certain viruses results in high morbidity and mortality accentuate the importance for development of new antivirals. The existing antiviral drugs are limited, due to th...
In-Silico Proteomic Exploratory Quest: Crafting T-Cell Epitope Vaccine Against Whipple's Disease [0.03%]
基于计算蛋白质组学的探索性研究：开发治疗惠普尔病的T细胞表位疫苗
Amit Joshi,Vikas Kaushik
Amit Joshi
Whipple's disease is one of the rare maladies in terms of spread but very fatal one as it is linked with many disorders (like Gastroenteritis, Endocarditis etc.). Also, current regimens include less effective drugs which require long durati...
Insight into Evolution and Conservation Patterns of B1-Subfamily Members of GPCR [0.03%]
G蛋白偶联受体B1亚家族的进化与保护规律探究
Chiranjib Chakraborty,Ashish Ranjan Sharma,Garima Sharma et al.
Chiranjib Chakraborty et al.
The diverse, evolutionary architectures of proteins can be regarded as molecular fossils, tracing a historical path that marks important milestones across life. The B1-subfamily of GPCRs (G-protein-coupled receptors) are medically significa...
In Silico Modeling of Crimean Congo Hemorrhagic Fever Virus Glycoprotein-N and Screening of Anti Viral Hits by Virtual Screening [0.03%]
克里米亚-刚果出血热病毒糖蛋白N的计算机建模及虚拟筛选抗病毒先导物
Sobia Ahsan Halim,Sobia Aziz,Mohammad Ilyas et al.
Sobia Ahsan Halim et al.
Crimean-Congo hemorrhagic fever (CCHF) is a widespread zoonotic viral disease, caused by a tick-born virus Crimean-Congo hemorrhagic fever virus (CCHFV). This disease is endemic in Middle East, Asia, Africa and South-Eastern Europe with the...
Study of the Binding Pattern of HLA Class I Alleles of Indian Frequency and cTAP Binding Peptide for Chikungunya Vaccine Development [0.03%]
印度HLA-I等位基因频率和cTAP结合肽的结合模式研究以开发 chickungunya疫苗
Prashant Saxena,Sanjay Mishra
Prashant Saxena
Chikungunya is a mosquito-borne disease, caused by the member of the Togaviridae family belongs to the genus alphavirus, making it a major threat in all developing countries as well as some developed countries. The mosquito acts as a vector...
Outer Membrane Protein, Oma87 Prevents Acinetobacter baumannii Infection [0.03%]
外膜蛋白Oma87阻止鲍曼不动杆菌感染
Iraj Rasooli,Raziyeh Abdolhamidi,Abolfazl Jahangiri et al.
Iraj Rasooli et al.
Acinetobacter baumannii is one of the most problematic pathogens in clinical settings. Emerging of its antibiotic-resistant strains persuade researchers to find alternative treatment options such as immunization against the notorious nosoco...
Exploring Lassa Virus Proteome to Design a Multi-epitope Vaccine Through Immunoinformatics and Immune Simulation Analyses [0.03%]
通过免疫信息学和免疫模拟分析探索拉沙病毒蛋白质组以设计多表位疫苗
Sifat Bin Sayed,Zulkar Nain,Md Shakil Ahmed Khan et al.
Sifat Bin Sayed et al.
Lassa virus (LASV) is responsible for a type of acute viral haemorrhagic fever referred to as Lassa fever. Lack of adequate treatment and preventive measures against LASV resulted in a high mortality rate in its endemic regions. In this stu...
Molecular Modelling and Insilico Engineering of PapMV-CP Towards Display and Development of Capripox Viral Like Particles Based on Immunogenic P32 Envelop Protein is the Homologous of the Vaccinia-Viral H3L Gene: An Insilico Approach [0.03%]
基于免疫原性P32包膜蛋白的山羊痘病毒样颗粒的展示及开发：一种反向计算方法（以痘病毒H3L基因为同源物）
Burranboina Kiran Kumar,K M Kumar,G B Manjunatha Reddy et al.
Burranboina Kiran Kumar et al.
Viral-like particles are assembled from capsid protein structural subunits of different viruses and have ability to establish research in biomedicals, like construction of novel safety vaccines, gene therapy vectors by delivering systems fo...
Characterization of Angiotensin Converting Enzyme-2 (ACE2) in Human Urine [0.03%]
人尿液中血管紧张素转换酶-2（ACE2）的特征分析
Rebecca A Lew,Fiona J Warner,Iresha Hanchapola et al.
Rebecca A Lew et al.
Angiotensin converting enzyme-2 (ACE2) is a recently described membrane-bound carboxypeptidase identified by its homology to ACE, the enzyme responsible for the formation of the potent vasoconstrictor angiotensin II (Ang II). ACE2 inactivat...
Production of a Monoclonal Antibody Targeting the M Protein of MERS-CoV for Detection of MERS-CoV Using a Synthetic Peptide Epitope Formulated with a CpG-DNA-Liposome Complex [0.03%]
基于合成肽表位的CpG-DNA-脂质体佐剂制备抗MERS-CoV M蛋白单克隆抗体用于直接检测MERS-CoV病毒感染的新方法
Byoung Kwon Park,Su In Lee,Joon-Yong Bae et al.
Byoung Kwon Park et al.
The Middle East respiratory syndrome-related coronavirus (MERS-CoV) contains four major structural proteins, the spike glycoprotein, nucleocapsid phosphoprotein, membrane (M) glycoprotein and small envelope glycoprotein. The M protein of ME...