Downhill running induced DNA damage enhances mitochondrial membrane permeability by facilitating ER-mitochondria signaling [0.03%]
下坡跑引起的DNA损伤通过促进内质网-线粒体信号转导提高线粒体膜通透性
Junping Li,Binting Zhao,Shengju Chen et al.
Junping Li et al.
To observe whether downhill running can lead to DNA damage in skeletal muscle cells and changes in mitochondrial membrane permeability and to explore whether the DNA damage caused by downhill running can lead to changes in mitochondrial mem...
Participation and performance characteristics in half-marathon run: a brief narrative review [0.03%]
半程马拉松比赛的参与和表现特征：简要叙述性评论
Pantelis Theodoros Nikolaidis,Beat Knechtle
Pantelis Theodoros Nikolaidis
Half-marathon (HM) is a running sport of increasing popularity in both sexes and in all age groups worldwide during the last years. Many studies have examined several aspects of HM, such as performance and participation trends, sex and age ...
Utility of the burmese Python as a model for studying plasticity of extreme physiological systems [0.03%]
缅甸蟒蛇在研究极端生理系统可塑性方面的应用价值
Yuxiao Tan,Thomas G Martin,Brooke C Harrison et al.
Yuxiao Tan et al.
Non-traditional animal models present an opportunity to discover novel biology that has evolved to allow such animals to survive in extreme environments. One striking example is the Burmese python (Python molurus bivittatus), which exhibits...
Kenton P Arkill,C Charles Michel,Elizabeth V M Rider et al.
Kenton P Arkill et al.
John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvemen...
Recent studies of the molecular mechanism of lusitropy due to phosphorylation of cardiac troponin I by protein kinase A [0.03%]
蛋白激酶A磷酸化心肌 Troponin I 的若干卢西特里作用的分子机制的研究
Steven Marston
Steven Marston
Ca2+ acts on troponin and tropomyosin to switch the thin filament on and off, however in cardiac muscle a more graded form of regulation is essential to tailor cardiac output to the body's needs. This is achieved by the action of adrenaline...
Daryl M Okamura,Elizabeth D Nguyen,Sarah J Collins et al.
Daryl M Okamura et al.
Fibrosis-driven solid organ failure is a major world-wide health burden with few therapeutic options. Spiny mice (genus: Acomys) are terrestrial mammals that regenerate severe skin wounds without fibrotic scars to evade predators. Recent st...
The effect of gender and obesity in modulating cross-bridge function in cardiac muscle fibers [0.03%]
性别和肥胖对心肌纤维交叉桥功能调节的影响
Jing Xi,Yuanchao Ye,Mohamad Mokadem et al.
Jing Xi et al.
The effect of obesity on cross-bridge (CB) function was investigated in mice lacking functional Melanocortin-4 Receptor (MC4R-/-), the loss of which causes dilated cardiomyopathy (DCM) in humans and mice. Skinned cardiac muscle fibers from ...
Calcium and strontium contractile activation properties of single skinned skeletal muscle fibres from elderly women 66-90 years of age [0.03%]
单个去皮骨骼肌纤维的钙和锶收缩激活特性（作者：66-90岁老年女性）
Susan M Ronaldson,D George Stephenson,Stewart I Head
Susan M Ronaldson
The single freshly skinned muscle fibre technique was used to investigate Ca2+- and Sr2+-activation properties of skeletal muscle fibres from elderly women (66-90 years). Muscle biopsies were obtained from the vastus lateralis muscle. Three...
Christian Aalkjær,Tobias Wang
Christian Aalkjær
Giraffes are the highest living animals on Earth and therefore are challenged by gravity more than any other species. In particular the cardiovascular system needs to adapt to this challenge. Giraffes have a mean blood pressure around 200 m...
Mechanisms of eccentric contraction-induced muscle damage and nutritional supplementations for mitigating it [0.03%]
离心收缩引起肌肉损伤的机制及营养补充的缓解作用
Keita Kanzaki,Daiki Watanabe,Jiayu Shi et al.
Keita Kanzaki et al.
Eccentric contraction (ECC) often results in large and long-lasting force deficits accompanied by muscle soreness, primarily due to muscle damage. In this sense, exercises that involve ECC are less desirable. Paradoxically, exercise trainin...