Calcium-dependent signaling mechanisms and soleus fiber remodeling under gravitational unloading [0.03%]
钙依赖性信号机制和失重引起的腓肠肌纤维重塑
Boris S Shenkman,T L Nemirovskaya
Boris S Shenkman
The decrease in postural muscle fiber size, diminishing of their contractile properties, slow-to-fast shift in myosin heavy chain expression pattern are known to be the main consequences of gravitational unloading. The Ca(2+) role in these ...
Myosin regulatory light chain phosphorylation inhibits shortening velocities of skeletal muscle fibers in the presence of the myosin inhibitor blebbistatin [0.03%]
肌球蛋白抑制剂blebbistatin存在时，肌球蛋白调节轻链磷酸化会抑制骨骼肌纤维的收缩速度
Melanie Stewart,Kathy Franks-Skiba,Roger Cooke
Melanie Stewart
Phosphorylation of skeletal myosin regulatory light chain (RLC) occurs in fatigue and may play a role in the inhibition of shortening velocities observed in vivo. Forces and shortening velocities were measured in permeabilized rabbit psoas ...
Kenneth C Holmes,William Lehman
Kenneth C Holmes
We argue that the overall behavior of tropomyosin on F-actin cannot be easily discerned by examining thin filaments reduced to their smallest interacting units. In isolation, the individual interactions of actin and tropomyosin, by themselv...
Caroline A Sewry
Caroline A Sewry
Congenital myopathies are a molecularly, pathologically and clinically heterogenous group of disorders defined by hypotonia and muscle weakness, that usually present at birth or early childhood, in association with a characteristic morpholo...
Regulation of fast skeletal muscle activity by SERCA1 vicinal-cysteines [0.03%]
SERCA1邻近半胱氨酸调节快速骨骼肌活性
Rocío Alvarez,Pável Vázquez,Francisco Pérez et al.
Rocío Alvarez et al.
During prolonged skeletal muscle contractions free radicals are produced that may lead to fatigue. Vicinal cysteines, known as a Vicinal-thiol groups react preferentially among them depending on redox potential. Therefore, we examined the r...
Multiplicity of experimental approaches to therapy for genetic muscle diseases and necessity for population screening [0.03%]
遗传性肌肉疾病的治疗实验手段多样性和人群筛查的必要性
Nigel G Laing
Nigel G Laing
Currently a multiplicity of experimental approaches to therapy for genetic muscle diseases is being investigated. These include replacement of the missing gene, manipulation of the gene message, repair of the mutation, upregulation of an al...
Back to square one: what do we know about the functions of muscle LIM protein in the heart? [0.03%]
重回起点：肌肉LIM蛋白在心脏中的功能知多少？
Katja Gehmlich,Christian Geier,Hendrik Milting et al.
Katja Gehmlich et al.
Muscle LIM Protein (MLP) is small, just 198 amino acid long protein, which is specifically expressed in slow skeletal muscle and cardiac tissues. This article will focus on the cardiac functions of MLP: the current knowledge about localisat...
Pedro Veliça,Chris M Bunce
Pedro Veliça
Muscle regeneration is a tightly orchestrated process where activated satellite cells (myoblasts) respond to external stimuli in order to proliferate, differentiate and fuse to damaged myofibers. Simultaneously, the injured tissue undergoes...
Richard Tregear
Richard Tregear