Inhibition of prostaglandin synthesis reduces the induction of MyoD expression in rat soleus muscle [0.03%]
抑制前列腺素合成可减少大鼠腓肠肌MyoD的诱导表达
M Monda,C Vicidomini,An Viggiano et al.
M Monda et al.
MyoD is a myogenic regulatory factor with a critical role in skeletal muscle development and regeneration. As muscle regeneration comes with an inflammatory process, it has been proposed that the inflammatory cells can play an important rol...
Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylation [0.03%]
心肌血流减少时收缩力下降与肌钙蛋白I磷酸化改变相关
Bridgette Christopher,Gresin O Pizarro,Bryson Nicholson et al.
Bridgette Christopher et al.
A rat model of low myocardial blood flow was established to test the hypothesis that post-translational changes to proteins of the thin and thick muscle filaments correlate with decreased cardiac contractility. Following 3 days of low blood...
Local calcium signals induced by hyper-osmotic stress in mammalian skeletal muscle cells [0.03%]
高渗压力诱导的哺乳动物骨骼肌细胞内钙信号响应研究
Simona Apostol,Daniel Ursu,Frank Lehmann-Horn et al.
Simona Apostol et al.
Strenuous activitiy of skeletal muscle leads to temporary osmotic dysbalance and isolated skeletal muscle fibers exposed to osmotic stress respond with characteristic micro-domain calcium signals. It has been suggested that osmotic stress t...
Direct visualisation and kinetic analysis of normal and nemaline myopathy actin polymerisation using total internal reflection microscopy [0.03%]
直接使用全内反射荧光显微镜观测正常和肌束病肌球蛋白聚合状况及其动力学分析
Juan-Juan Feng,Dmitry S Ushakov,Michael A Ferenczi et al.
Juan-Juan Feng et al.
Actin filaments were formed by elongation of pre-formed nuclei (short crosslinked actin-HMM complexes) that were attached to a microscope cover glass. By using TIRF illumination we could see actin filaments at high contrast despite the pres...
Altered fast- and slow-twitch muscle fibre characteristics in female mice with a (S248F) knock-in mutation of the brain neuronal nicotinic acetylcholine receptor [0.03%]
脑神经烟碱型乙酰胆碱受体(S248F)基因敲入突变小鼠的快肌纤维和慢肌纤维表型发生改变
David J Cannata,David I Finkelstein,Ilse Gantois et al.
David J Cannata et al.
We generated a mouse line with a missense mutation (S248F) in the gene (CHRNA4) encoding the alpha4 subunit of neuronal nicotinic acetylcholine receptor (nAChR). Mutant mice demonstrate brief nicotine induced dystonia that resembles the cli...
Is high concentration of parvalbumin a requirement for superfast relaxation? [0.03%]
高浓度的神经营养蛋白是否是超强快速舒张的必要条件？
Boris A Tikunov,Lawrence C Rome
Boris A Tikunov
It is generally thought that the rapid relaxation of fast muscles is facilitated by the Ca(2+) binding protein parvalbumin (Parv). Indeed superfast swimbladder (SWB) muscle of toadfish contains the largest concentration of this protein ever...
Paul Pfleiderer,Marius P Sumandea,Vitalyi O Rybin et al.
Paul Pfleiderer et al.
Phosphorylation of cardiac troponin is a key mechanism involved in regulation of contractile function. In vitro kinase assays revealed that lysates prepared from resting cardiomyocytes contain cardiac troponin I (cTnI) and cTnT kinase activ...
Christiane Look,Ingo Morano,Valéria Lamounier-Zepter
Christiane Look
Obesity is a major risk factor for metabolic syndrome and cardiovascular disorders. Obesity related heart disease is the most serious complication of human obesity. Despite several investigations the pathophysiological mechanisms involved r...
Sabine J van Dijk,Nazha Hamdani,Ger J M Stienen et al.
Sabine J van Dijk et al.
Many changes in morphology, biochemical properties and myocyte function occur during development to heart failure. Most changes may be compensatory, yet unable to prevent cardiac dysfunction in the long run. This illustrates that it is impo...
From genotype to phenotype: a longitudinal study of a patient with hypertrophic cardiomyopathy due to a mutation in the MYBPC3 gene [0.03%]
从基因型到表型：MYBPC3基因突变所致肥厚性心肌病患者的纵向研究
Adam Jacques,Anita C Hoskins,Jonathan C Kentish et al.
Adam Jacques et al.
Many of the links between the genotype and phenotype in hypertrophic cardiomyopathy remain unexplained. In this unique longitudinal study we have investigated a patient with classical clinical phenotypic features of hypertrophic obstructive...