Morphological characteristics of cardiac calcium release units in animals with metabolic and circulatory disorders [0.03%]
代谢和循环紊乱动物心脏钙释放单位的形态特征
Kelly F McGrath,Atsumu Yuki,Yasutaka Manaka et al.
Kelly F McGrath et al.
Metabolic and circulatory disorders such as diabetes and hypertension are associated with cardiac dysfunction. Research on these types of experimental animals has observed abnormal calcium (Ca(2+)) sparks and waves in cells; a potential mec...
The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling [0.03%]
脊椎动物肌肉Z线：肌节结构和信号转导的结合位点
Pradeep K Luther
Pradeep K Luther
The Z-disc, appearing as a fine dense line forming sarcomere boundaries in striated muscles, when studied in detail reveals crosslinked filament arrays that transmit tension and house myriads of proteins with diverse functions. At the Z-dis...
Ryanodine modification of RyR1 retrogradely affects L-type Ca(2+) channel gating in skeletal muscle [0.03%]
ryanodine对RYR1的修饰使L型Ca(2+)通道在骨骼肌中的门控发生逆向改变
R A Bannister,K G Beam
R A Bannister
In skeletal muscle, there is bidirectional signalling between the L-type Ca(2+) channel (1,4-dihydropyridine receptor; DHPR) and the type 1 ryanodine-sensitive Ca(2+) release channel (RyR1) of the sarcoplasmic reticulum (SR). In the case of...
Characterization of secophalloidin-induced force loss in cardiac myofibrils [0.03%]
Secophalloidin引起心肌丝力产生障碍的特征研究
Anna E Bukatina,Gary C Sieck,Kenneth B Campbell et al.
Anna E Bukatina et al.
Secophalloidin (SPH) is known to cause in cardiac myofibrils force without Ca(2+) (half-maximal effect approximately 2 mM) followed by irreversible loss of Ca(2+)-activated force. At maximal Ca(2+) activation, SPH increases force (half-maxi...
Mechanical properties of intact single fibres from wild-type and MLC/mIgf-1 transgenic mouse muscle [0.03%]
野生型和MLC/mIGF-1转基因小鼠肌肉的完整单纤维力学性能
Barbara Colombini,Giulia Benelli,Marta Nocella et al.
Barbara Colombini et al.
The effects of overexpression of the local form of insulin like growth factor-1 (mIgf-1) on skeletal muscle were investigated by comparing the mechanical properties of single intact fibres from the flexor digitorum brevis of wild-type (WT) ...
V Salnikov,Y O Lukyanenko,W J Lederer et al.
V Salnikov et al.
Ryanodine receptors (RyRs) are the major ion channels in the sarcoplasmic reticulum responsible for Ca2+ release in muscle cells. Localization of RyRs is therefore critical to our understanding of Ca2+ cycling and Ca2+-dependent processes w...
Tetanic depression and catch-like effect in fast motor units of the rat medial gastrocnemius at linearly increasing and decreasing stimulation frequencies [0.03%]
大鼠胫骨前肌线性增加和减少刺激频率时快速运动神经元单位的强直抑郁和类似捕鱼的效果
Dawid Łochyński,Jan Celichowski
Dawid Łochyński
The forces developed by fast resistant (FR) and fast fatigable (FF) motor units of the rat medial gastrocnemius during trains of electrical stimuli at linearly increasing or decreasing frequency were measured at the instantaneous frequency ...
Back to the future: new techniques show that forgotten phosphorylation sites are present in contractile proteins of the heart whilst intensively studied sites appear to be absent [0.03%]
回溯过去，展望未来：新的技术表明，遗忘的磷酸化位点存在于心脏收缩蛋白中，而备受研究的位点则似乎不存在
Steven B Marston,Jeffrey W Walker
Steven B Marston
Thermal preconditioning prevents fiber type transformation of the unloading induced-atrophied muscle in rats [0.03%]
热预处理可防止失重所致大鼠肌纤维类型转换
Isao Takeda,Hidemi Fujino,Shinichiro Murakami et al.
Isao Takeda et al.
Muscle atrophy is accompanied by a slow-to-fast transformation of the slow muscle, e.g., the soleus muscle, which is characterized by a decrease in the expression of the slow myosin heavy chain (MyHC) isoform. Heat stress before hindlimb un...
Different fibre populations distinguished by their calcium transient characteristics in enzymatically dissociated murine flexor digitorum brevis and soleus muscles [0.03%]
不同钙瞬变特征的纤维群在番木瓜蛋白酶消化法分离的小鼠足底和腓肠肌中的分布
Juan C Calderón,Pura Bolaños,Sonia H Torres et al.
Juan C Calderón et al.
Enzymatically dissociated flexor digitorum brevis (FDB) and soleus fibres from mouse were used to compare the kinetics of electrically elicited Ca2+ transients of slow and fast skeletal muscle fibres, using the fast Ca2+ dye MagFluo4-AM, at...