Effects of membrane cholesterol-targeting chemicals on skeletal muscle contractions evoked by direct and indirect stimulation [0.03%]
靶向膜胆固醇的化学物质对直接和间接刺激诱发的骨骼肌收缩的影响
Nikita S Fedorov,Artem I Malomouzh,Alexey M Petrov
Nikita S Fedorov
Cholesterol is one of the major components of plasma membrane, where its distribution is nonhomogeneous and it participates in lipid raft formation. In skeletal muscle cholesterol and lipid rafts seem to be important for excitation-contract...
IFRD2, a target of miR-2400, regulates myogenic differentiation of bovine skeletal muscle satellite cells via decreased phosphorylation of ERK1/2 proteins [0.03%]
miR-2400靶基因IFRD2通过降低ERK1/2磷酸化水平促进牛肌卫星细胞向分化方向发育的研究
Zhian Gong,Xiaoyu Zhang,Jingxuan Cui et al.
Zhian Gong et al.
The proliferation and differentiation of skeletal muscle satellite cells is a complex physiological process involving various transcription factors and small RNA molecules. This study aimed to understand the regulatory mechanisms underlying...
The effects of exercise and mitochondrial transplantation alone or in combination against Doxorubicin-induced skeletal muscle atrophy [0.03%]
运动和线粒体移植单独或联合应用对阿霉素诱导的骨骼肌萎缩的作用
Gokhan Burcin Kubat,Oner Ulger,Ozbeyen Atalay et al.
Gokhan Burcin Kubat et al.
Doxorubicin (DOX) is a chemotherapy drug used to treat various types of cancer, but it is associated with significant side effects such as skeletal muscle atrophy. Exercise has been found to prevent skeletal muscle atrophy through the modul...
Josh E Baker
Josh E Baker
Accurate models of muscle contraction are important for understanding both muscle performance and the therapeutics that enhance physiological function. However, models are only accurate and meaningful if they are consistent with physical la...
Danicamtiv affected isometric force and cross-bridge kinetics similarly in skinned myocardial strips from male and female rats [0.03%]
丹尼卡替伏对雄性和雌性大鼠去甲肾上腺素条等张力和跨桥动力学的影响相似
Peter O Awinda,Blake J Vander Top,Kyrah L Turner et al.
Peter O Awinda et al.
Myotropes are pharmaceuticals that have recently been developed or are under investigation for the treatment of heart diseases. Myotropes have had varied success in clinical trials. Initial research into myotropes have widely focused on ani...
AMPK and glucose deprivation exert an isoform-specific effect on the expression of Na+,K+-ATPase subunits in cultured myotubes [0.03%]
AMPK和葡萄糖剥夺对培养的肌管中Na +，K + -ATP酶亚基表达的异构体特异性影响
Anja Vidović,Klemen Dolinar,Alexander V Chibalin et al.
Anja Vidović et al.
In skeletal muscle, Na+,K+-ATPase (NKA), a heterodimeric (α/β) P-type ATPase, has an essential role in maintenance of Na+ and K+ homeostasis, excitability, and contractility. AMP-activated protein kinase (AMPK), an energy sensor, increase...
ANKRD1 expression is aberrantly upregulated in the mdm mouse model of muscular dystrophy and induced by stretch through NFκB [0.03%]
ANKRD1在mdm肌营养不良小鼠模型中异常高表达并通过NF-κB由牵张诱导表达
Michael A Lopez,Patricia S Pardo,Junaith S Mohamed et al.
Michael A Lopez et al.
The muscular dystrophy with myositis (mdm) mouse model results in a severe muscular dystrophy due to an 83-amino-acid deletion in the N2A region of titin, an expanded sarcomeric protein that functions as a molecular spring which senses and ...
Validation of a novel western blot assay to monitor patterns and levels of alpha dystroglycan in skeletal muscle of patients with limb girdle muscular dystrophies [0.03%]
用于监测肢带型肌营养不良患者骨骼肌中α- dystroglycan模式和水平的一种新型Western印迹测定的验证
Thulashitha Rajasingham,Hector M Rodriguez,Andreas Betz et al.
Thulashitha Rajasingham et al.
The cell membrane protein, dystroglycan, plays a crucial role in connecting the cytoskeleton of a variety of mammalian cells to the extracellular matrix. The α-subunit of dystroglycan (αDG) is characterized by a high level of glycosylatio...
Arginine ingestion inhibits phagocyte invasion in eccentrically contracted rat fast-twitch muscle [0.03%]
鸟氨酸摄入抑制外周血细胞向离心收缩大鼠快肌纤维的浸润
Keita Kanzaki,Masanobu Wada
Keita Kanzaki
Eccentric contraction (ECC) has been shown to induce leukocyte invasion into skeletal muscle, resulting in muscle inflammation. This study aimed to investigate whether prior ingestion of L-arginine (ARG), a nitric oxide precursor, inhibits ...
Biomechanical evaluation of flash-frozen and cryo-sectioned papillary muscle samples by using sinusoidal analysis: cross-bridge kinetics and the effect of partial Ca2+ activation [0.03%]
采用正弦分析法对速冻切片的乳头肌样品进行生物力学评价：横桥动力学和部分Ca2+激活的影响
Jing Xi,Han-Zhong Feng,Jian-Ping Jin et al.
Jing Xi et al.
We examined the integrity of flash-frozen and cryo-sectioned cardiac muscle preparations (introduced by Feng and Jin, 2020) by assessing tension transients in response to sinusoidal length changes at varying frequencies (1-100 Hz) at 25 °C...