Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity [0.03%]
条状肌 tropomyosin 型别不同地调节心脏性能和细肌丝钙敏感度
Ganapathy Jagatheesan,Sudarsan Rajan,Rafeeq P H Ahmed et al.
Ganapathy Jagatheesan et al.
Tropomyosin (TM) plays a central role in calcium mediated striated muscle contraction. There are three muscle TM isoforms: alpha-TM, beta-TM, and gamma-TM. alpha-TM is the predominant cardiac and skeletal muscle isoform. beta-TM is expresse...
Nitric oxide regulates stretch-induced proliferation in C2C12 myoblasts [0.03%]
一氧化氮调节C2C12肌细胞的机械张力诱导增殖作用
Quinlyn A Soltow,Vitor A Lira,Jenna L Betters et al.
Quinlyn A Soltow et al.
Mechanical stretch of skeletal muscle activates nitric oxide (NO) production and is an important stimulator of satellite cell proliferation. Further, cyclooxygenase (COX) activity has been shown to promote satellite cell proliferation in re...
Nonmuscle myosin IIA with a GFP fused to the N-terminus of the regulatory light chain is regulated normally [0.03%]
N端荧光素酶标记的非肌肉肌球蛋白IIA的功能研究
Andras Kengyel,Wendy A Wolf,Rex L Chisholm et al.
Andras Kengyel et al.
Nonmuscle myosin II plays a crucial role in a variety of cellular processes (e.g., polarity formation, cell motility, and cytokinesis). It is composed of two heavy chains, two regulatory light chains and two essential light chains. The ATPa...
CT-GalNAc transferase overexpression in adult mice is associated with extrasynaptic utrophin in skeletal muscle fibres [0.03%]
CT-GalNAc转移酶在成年小鼠中的过表达与骨骼肌纤维的细胞外泛素有关
Margaret Durko,Carol Allen,Josephine Nalbantoglu et al.
Margaret Durko et al.
Duchenne muscular dystrophy is a genetic muscle disease characterized by the absence of sub-sarcolemmal dystrophin that results in muscle fibre necrosis, progressive muscle wasting and is fatal. Numerous experimental studies with dystrophin...
Low-intensity electrical stimulation ameliorates disruption of transverse tubules and neuromuscular junctional architecture in denervated rat skeletal muscle fibers [0.03%]
低强度电刺激改善去神经大鼠骨骼肌纤维横小管和神经肌肉接头结构的紊乱
Kounosuke Tomori,Yukiko Ohta,Tomie Nishizawa et al.
Kounosuke Tomori et al.
We determine the effects of direct electrical stimulation (ES) on the histological profiles in atrophied skeletal muscle fibers after denervation caused by nerve freezing. Direct ES was performed on the tibialis anterior (TA) muscle after d...
Investigation of changes in skeletal muscle alpha-actin expression in normal and pathological human and mouse hearts [0.03%]
正常及病理人心肌和小鼠心肌中骨骼肌α-actin表达变化的初步研究
O&#x;Neal Copeland,Kristen J Nowak,Nigel G Laing et al.
O&#x;Neal Copeland et al.
We have developed a quantitative antibody-based assay to measure the content of skeletal muscle alpha-actin relative to cardiac alpha-actin. We found 21 +/- 2% skeletal muscle alpha-actin content in normal heart muscle of adult man and mous...
Influence of 14-day hind limb unloading on isolated muscle spindle activity in rats [0.03%]
大鼠14天悬吊去负荷对孤立肌梭活动的影响
Xue Hong Zhao,Xiao Li Fan,Xin Ai Song et al.
Xue Hong Zhao et al.
During hind limb unloading (HU), the soleus is often in a shortened position and the natural physiological stimulus of muscle spindles is altered, such that muscle spindle activity also changes. Using isolated spindle conditions, the presen...
In vitro motility of native thin filaments from Drosophila indirect flight muscles reveals that the held-up 2 TnI mutation affects calcium activation [0.03%]
果蝇间接飞行肌原生细丝的体外滑动实验表明，2号TnI突变影响钙激活作用
P G Vikhorev,N N Vikhoreva,A Cammarato et al.
P G Vikhorev et al.
A procedure for the isolation of regulated native thin filaments from the indirect flight muscles (IFM) of Drosophila melanogaster is described. These are the first striated invertebrate thin filaments to show Ca-regulated in vitro motility...
Seven days of muscle re-loading and voluntary wheel running following hindlimb suspension in mice restores running performance, muscle morphology and metrics of fatigue but not muscle strength [0.03%]
七天的肌肉再加载和自愿跑步恢复了小鼠的跑步表现、肌肉形态和疲劳指标，但未恢复肌肉力量
Andrea M Hanson,Louis S Stodieck,Cara M A Cannon et al.
Andrea M Hanson et al.
In this study, we examined the effects of 2-week hindlimb un-loading in mice followed by re-ambulation with voluntary access to running wheels. The recovery period was terminated at a time point when physical performance--defined by velocit...
Two inhibitors of store operated Ca2+ entry suppress excitation contraction coupling in frog skeletal muscle [0.03%]
两种储积操作的Ca2+进入抑制剂可抑制蛙骨骼肌的兴奋收缩耦联
J Fernando Olivera,Gonzalo Pizarro
J Fernando Olivera
Two drugs, 2-APB and SKF-96365, commonly used to block Store Operated Ca(2+) Entry (SOCE) were found to have inhibitory effects at different levels of the Excitation Contraction Coupling (ECC) process in frog skeletal muscle fibers. Treatme...