Lineage-based primary muscle fiber type diversification independent of MEF2 and NFAT in chick embryos [0.03%]
鸡胚原肌管谱系依赖的肌纤维类型的分化独立于MEF2和NFAT的作用
Jillian Theobald,Joseph X DiMario
Jillian Theobald
Differences in primary avian skeletal muscle fiber types are based on myoblast cell lineages and independent of innervation. To understand the basis for this mode of myogenesis, embryonic myoblasts specifically committed to the formation of...
Thomas M Butler,Marion J Siegman
Thomas M Butler
Permeabilized anterior byssus retractor muscles (ABRM) from Mytilus edulis were used as a simple system to test whether there is a stretch dependent activation of a kinase as has been postulated for titin and the mini-titin twitchin. The AB...
Myosin binding protein-C: an essential protein in skeletal and cardiac muscle [0.03%]
肌球蛋白结合蛋白C：骨骼肌和心肌中的重要结构蛋白
Pradeep K Luther,Anupama Vydyanath
Pradeep K Luther
Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation [0.03%]
肌钙蛋白-κ表达诱导扩张型心肌病并抑制心肌细丝张力的机制涉及跨桥依赖激活和肌钙蛋白磷酸化改变
Chehade N Karam,Chad M Warren,Sudarsan Rajan et al.
Chehade N Karam et al.
Tropomyosin-kappa (TPM1-κ) is a newly discovered tropomyosin (TM) isoform that is exclusively expressed in the human heart and generated by an alternative splicing of the α-TM gene. We reported that TPM1-κ expression was increased in the...
The basketweave form of the Z-band is expanded relative to the small-square form [0.03%]
Z线的篮状结构形式相对于小方格形式被扩展
Robert J Perz-Edwards
Robert J Perz-Edwards
Tissue procurement strategies affect the protein biochemistry of human heart samples [0.03%]
取样策略影响人体心脏样本的蛋白质化学性质
Lori A Walker,Allen M Medway,John S Walker et al.
Lori A Walker et al.
The ability to analyze the biochemical properties of human cardiac tissue is critical both to an understanding of cardiac pathology and also to the development of novel pharmacotherapies. However current strategies for tissue procurement ar...
More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease [0.03%]
与缺血性心脏病相比，扩张型心肌病具有更为严重的细胞表型
Nazha Hamdani,Attila Borbély,Sophie P G R Veenstra et al.
Nazha Hamdani et al.
Activation of the β-adrenergic receptor (βAR) pathway is the main mechanism of the heart to increase cardiac output via protein kinase A (PKA)-mediated phosphorylation of cellular target proteins, and perturbations therein may contribute ...
Crossbridge and filament compliance in muscle: implications for tension generation and lever arm swing [0.03%]
肌原纤维的力学顺应性对横桥力和力臂长度变化的影响
Gerald Offer,K W Ranatunga
Gerald Offer
The stiffness of myosin heads attached to actin is a crucial parameter in determining the kinetics and mechanics of the crossbridge cycle. It has been claimed that the stiffness of myosin heads in the anterior tibialis muscle of the common ...
Rapid decrease in active tension generated by C2C12 myotubes after termination of artificial exercise [0.03%]
终止人工运动后C2C12肌管主动张力快速下降
Hideaki Fujita,Minoru Hirano,Kazunori Shimizu et al.
Hideaki Fujita et al.
We found that the active tension of C2C12 myotubes that had been subjected to artificial exercise for ~10 days decreased rapidly after termination of the artificial exercise. When differentiated C2C12 myotubes were subjected to continuous 1...
Ian Curtis Smith,Jian Huang,Joe Quadrilatero et al.
Ian Curtis Smith et al.
X-linked muscular dystrophy of the mouse (mdx) has been reported to progressively remodel skeletal muscle to preferentially reduce fast fiber composition. Despite this, mdx muscle displays normal levels of posttetanic potentiation (PTP). Si...