Muscle injury induced by different types of contractions in dystrophic mdx mice [0.03%]
不同收缩类型引起的杜氏型mdx小鼠肌肉损伤
Jianwei Lou,Wenbo Bi,Wei Li et al.
Jianwei Lou et al.
Studies on comparing the effect of lengthening, isometric and shortening contractions on dystrophin-deficient muscles are unavailable. We hypothesized that different types of contractions lead to different extents to which dystrophin-defici...
Structure and dynamics of the actin-based smooth muscle contractile and cytoskeletal apparatus [0.03%]
基于肌动蛋白的平滑肌收缩和细胞骨架装置的结构与动力学
William Lehman,Kathleen G Morgan
William Lehman
The thin filaments of differentiated smooth muscle cells are composed of actin and tropomyosin isoforms and numerous ancillary actin-binding proteins that assemble together into distinct thin filament classes. These different filament class...
Ralph Knöll
Ralph Knöll
Myosin binding protein C (MYBPC) is a crucial component of the sarcomere and an important regulator of muscle function. While mutations in different myosin binding protein C (MYBPC) genes are well known causes of various human diseases, suc...
Lessons from calsequestrin-1 ablation in vivo: much more than a Ca(2+) buffer after all [0.03%]
钙调素-1活体缺失的启示：不仅仅是钙离子缓冲剂
Feliciano Protasi,Cecilia Paolini,Marta Canato et al.
Feliciano Protasi et al.
Calsequestrin type-1 (CASQ1), the main sarcoplasmic reticulum (SR) Ca(2+) binding protein, plays a dual role in skeletal fibers: a) it provides a large pool of rapidly-releasable Ca(2+) during excitation-contraction (EC) coupling; and b) it...
Diederik W D Kuster,Amira Cholid Bawazeer,Ruud Zaremba et al.
Diederik W D Kuster et al.
Perturbations in sarcomeric function may in part underlie systolic and diastolic dysfunction of the failing heart. Sarcomeric dysfunction has been ascribed to changes in phosphorylation status of sarcomeric proteins caused by an altered bal...
Myosin VI in PC12 cells plays important roles in cell migration and proliferation but not in catecholamine secretion [0.03%]
肌球蛋白VI在PC12细胞中的作用及其在细胞迁移和增殖中的重要作用以及其不参与儿茶酚胺分泌的作用机制研究
Łukasz Majewski,Magdalena Sobczak,Anna Wasik et al.
Łukasz Majewski et al.
Myosin VI (MVI) is the only known myosin walking towards minus end of actin filaments and is believed to play distinct role(s) than other myosins. We addressed a role of this unique motor in secretory PC12 cells, derived from rat adrenal me...
Belinda Bullard,Annalisa Pastore
Belinda Bullard
The rapid movement of the wings in small insects is powered by the indirect flight muscles. These muscles are capable of contracting at up to 1,000 Hz because they are activated mechanically by stretching. The mechanism is so efficient that...
cMyBP-C as a promiscuous substrate: phosphorylation by non-PKA kinases and its potential significance [0.03%]
兼性底物cMyBP-C：非PKA激酶介导的磷酸化及其潜在意义
Sonya C Bardswell,Friederike Cuello,Jonathan C Kentish et al.
Sonya C Bardswell et al.
It is now generally accepted that phosphorylation of cMyBP-C is critically important in maintaining normal cardiac function. Although much of the work to date on phospho-regulation of cMyBP-C has focused on the role of protein kinase A (PKA...
Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice [0.03%]
肾上腺素应激揭示了Mybpc3目标敲入小鼠的隔室肥大和蛋白酶体损伤
Saskia Schlossarek,Friederike Schuermann,Birgit Geertz et al.
Saskia Schlossarek et al.
Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric septal hypertrophy and is often caused by mutations in MYBPC3 gene encoding cardiac myosin-binding protein C. In contrast to humans, who are already affected at the heterozygo...