Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A [0.03%]
蛋白激酶C抑制心室肌细胞功率输出并削弱蛋白激酶A诱导的肌小节反应
Aaron C Hinken,Laurin M Hanft,Sarah B Scruggs et al.
Aaron C Hinken et al.
Following activation by G-protein-coupled receptor agonists, protein kinase C (PKC) modulates cardiac myocyte function by phosphorylation of intracellular targets including myofilament proteins cardiac troponin I (cTnI) and cardiac myosin b...
J F Olivera,Gonzalo Pizarro
J F Olivera
Ca²⁺ influx across the plasma membrane upon drastic reduction of the sarcoplasmic reticulum Ca²⁺ content was studied in voltage clamped frog skeletal muscle fibers. Depletion was produced by the application of 30 μM cyclopiazonic acid ...
Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro [0.03%]
体外心肌肌球蛋白结合蛋白C的N端区域的致病性研究
Suresh Govindan,Jason Sarkey,Xiang Ji et al.
Suresh Govindan et al.
Cardiac myosin binding protein-C (cMyBP-C) plays a role in sarcomeric structure and stability, as well as modulating heart muscle contraction. The 150 kDa full-length (FL) cMyBP-C has been shown to undergo proteolytic cleavage during ischem...
Structure, interactions and function of the N-terminus of cardiac myosin binding protein C (MyBP-C): who does what, with what, and to whom? [0.03%]
心脏肌球蛋白结合蛋白C(N端-Myl-BP-C):谁在做什么，与谁互动，目的是什么？
Mark Pfuhl,Mathias Gautel
Mark Pfuhl
The thick filament protein myosin-binding protein-C shows a highly modular architecture, with the C-terminal region responsible for tethering to the myosin and titin backbone of the thick filament. The N-terminal region shows the most signi...
Specific effects of endurance and sprint training on protein expression of calsequestrin and SERCA in mouse skeletal muscle [0.03%]
有氧和高强度训练对小鼠骨骼肌糖钙蛋白和SERCA蛋白质表达的特异性影响
Sanni Kinnunen,Satu Mänttäri
Sanni Kinnunen
Calsequestrin (CSQ) is the main Ca²⁺ binding protein inside the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. The present study demonstrates the specific effects of different training regimens on CSQ isoform 1 (CSQ1, the pri...
Coupling of kinesin ATP turnover to translocation and microtubule regulation: one engine, many machines [0.03%]
驱动蛋白ATP转换与移动和微管调节的耦合：一个引擎，多种设备
Claire T Friel,Jonathon Howard
Claire T Friel
The cycle of ATP turnover is integral to the action of motor proteins. Here we discuss how variation in this cycle leads to variation of function observed amongst members of the kinesin superfamily of microtubule associated motor proteins. ...
Developmental regulation of MURF E3 ubiquitin ligases in skeletal muscle [0.03%]
肌肉萎缩素E3泛素连接酶的肌细胞表达及调节机制研究进展
Sue Perera,Baljinder Mankoo,Mathias Gautel
Sue Perera
The striated muscle-specific tripartite motif (TRIM) proteins TRIM63/MURF1, TRIM55/MURF2 and TRIM54/MURF3 can function as E3 ubiquitin ligases in ubiquitin-mediated muscle protein turnover. Despite the well-characterised role of MURF1 in sk...
Axial distribution of myosin binding protein-C is unaffected by mutations in human cardiac and skeletal muscle [0.03%]
人的心肌和骨骼肌中的肌球蛋白结合蛋白-C的轴向分布不受突变的影响
Anupama Vydyanath,Christina A Gurnett,Steve Marston et al.
Anupama Vydyanath et al.
Myosin binding protein-C (MyBP-C), a major thick filament associated sarcomeric protein, plays an important functional and structural role in regulating sarcomere assembly and crossbridge formation. Missing or aberrant MyBP-C proteins (both...
Impact of the carbazole derivative wiskostatin on mechanical stability and dynamics of motile cells [0.03%]
卡唑衍生物wiskostatin对运动细胞机械稳定性和动力学的影响
Eva K B Pfannes,Matthias Theves,Christian Wegner et al.
Eva K B Pfannes et al.
Many essential functions in eukaryotic cells like phagocytosis, division, and motility rely on the dynamical properties of the actin cytoskeleton. A central player in the actin system is the Arp2/3 complex. Its activity is controlled by mem...
A possible role of the cholinergic and purinergic receptor interaction in the regulation of the rat urinary bladder function [0.03%]
胆碱能和嘌呤受体相互作用在大鼠膀胱功能调节中可能的作用
Ágnes Jenes,Ferenc Ruzsnavszky,Andrea Telek et al.
Ágnes Jenes et al.
The contractile activation of the upper (dome) and lower (base) parts of the urinary bladder show some differences. Cellular mechanisms that might be responsible for cholinergic effects blocking non-adrenergic non-cholinergic contractions i...