Characterizations of myosin essential light chain's N-terminal truncation mutant Δ43 in transgenic mouse papillary muscles by using tension transients in response to sinusoidal length alterations [0.03%]
正弦长度变化引起的肌小节张力反应在转基因小鼠乳头肌中表征肌球蛋白必要轻链的N-末端截短突变体Δ43的作用机制
Li Wang,Priya Muthu,Danuta Szczesna-Cordary et al.
Li Wang et al.
Cross-bridge kinetics were studied at 20 °C in cardiac muscle strips from transgenic (Tg) mice expressing N-terminal 43 amino acid truncation mutation (Δ43) of myosin essential light chain (ELC), and the results were compared to those fro...
The troponin I: inhibitory peptide uncouples force generation and the cooperativity of contractile activation in mammalian skeletal muscle [0.03%]
抑制肽切断哺乳动物骨骼肌中力生成和收缩激活的合作关系
Fred Schachat,Philip W Brandt
Fred Schachat
Hodges and his colleagues identified a 12 amino acid fragment of troponin I (TnI-ip) that inhibits Ca(2+)-activated force and reduces the effectiveness Ca(2+) as an activator. To understand the role of troponin C (TnC) in the extended coope...
Mechanism of force enhancement during stretching of skeletal muscle fibres investigated by high time-resolved stiffness measurements [0.03%]
通过高时间分辨刚度测量研究肌肉拉伸增强的机制
Marta Nocella,Maria Angela Bagni,Giovanni Cecchi et al.
Marta Nocella et al.
Stretching of active muscles leads to a great enhancement of the force developed without increased ATP consumption. The mechanism of force enhancement is still debated and it is not clear if it is due to increased crossbridge strain or to a...
Marion J Siegman,Sandra Davidheiser,Susan U Mooers et al.
Marion J Siegman et al.
This study determined the factors that limit force production and shortening in two smooth muscles having very different relationships between active and passive force as a function of muscle length. The rat anococcygeus muscle develops act...
Myopodin is an F-actin bundling protein with multiple independent actin-binding regions [0.03%]
肌节蛋白是一种具有多个独立结合位点的F-肌动蛋白聚合物蛋白质
Anja Linnemann,Padmanabhan Vakeel,Eduardo Bezerra et al.
Anja Linnemann et al.
The assembly of striated muscle myofibrils is a multistep process in which a variety of proteins is involved. One of the first and most important steps in myofibrillogenesis is the arrangement of thin myofilaments into ordered I-Z-I brushes...
Toshio Yanagida,Yoshiharu Ishii
Toshio Yanagida
Single molecule measurements have shown that a muscle myosin step is driven by biased Brownian movement. Furthermore, they have also demonstrated that in response to strain in the backward direction a detached myosin head preferentially att...
Conformational changes at the nucleotide site in the presence of bound ADP do not set the velocity of fast Drosophila myosins [0.03%]
与ADP结合时作用于核苷酸位点的构象变化不能设定快速果蝇肌球蛋白的速度
Catherine C Eldred,Nariman Naber,Edward Pate et al.
Catherine C Eldred et al.
The conformational changes in myosin associated with ADP release and their influence on actin sliding velocity are not understood. Following actin binding, the myosin active site is in equilibrium between a closed and open ADP bound state, ...
Contribution of oxidative stress to pathology in diaphragm and limb muscles with Duchenne muscular dystrophy [0.03%]
氧化应激对杜氏肌营养不良膈肌和四肢肌肉病理的贡献
Jong-Hee Kim,Hyo-Bum Kwak,LaDora V Thompson et al.
Jong-Hee Kim et al.
Duchenne muscular dystrophy (DMD) is a degenerative skeletal muscle disease that makes walking and breathing difficult. DMD is caused by an X-linked (Xp21) mutation in the dystrophin gene. Dystrophin is a scaffolding protein located in the ...
Anna V Dobrzhanskaya,Ilya G Vyatchin,Stanislav S Lazarev et al.
Anna V Dobrzhanskaya et al.
We isolated Ca(2+)-regulated thin filaments from the smooth muscle of the mussel Crenomytilus grayanus and studied the protein composition of different preparations from this muscle: whole muscle, heat-stable extract, fractions from heat-st...
A rat model study of atrophy of denervated musculature of the hand being faster than that of denervated muscles of the arm [0.03%]
关于手部肌肉萎缩快于前臂肌肉离体后萎缩的实验研究
Ji-xin Wu,Liang Chen,Fei Ding et al.
Ji-xin Wu et al.
There are no biological marks to indicate if denervated muscle atrophy after nerve injury is irreversible. Clinically in obstetric brachial plexus palsy (OBPP), atrophy of denervated intrinsic musculature of the hand is much faster to irrev...