Skeletal muscle myopathy mutations at the actin tropomyosin interface that cause gain- or loss-of-function [0.03%]
作用于肌动蛋白-原肌球蛋白界面的肌肉病突变导致功能获得或丧失
Massimiliano Memo,Steven Marston
Massimiliano Memo
It is well known that the regulation of muscle contraction relies on the ability of tropomyosin to switch between different positions on the actin filament, but it is still not well understood which amino acids are directly involved in the ...
Tropomyosin isoform expression and phosphorylation in the human heart in health and disease [0.03%]
健康与疾病心脏中肌球蛋白异构体的表达和磷酸化
Steven B Marston,O&#x;Neal Copeland,Andrew E Messer et al.
Steven B Marston et al.
We determined the isoforms of tropomyosin expressed and the level of tropomyosin phosphorylation in donor, end-stage failing and hypertrophic obstructive cardiomyopathy samples of human heart muscle. Western blots and isoform-specific antib...
Complex tropomyosin and troponin T isoform expression patterns in orbital and global fibers of adult dog and rat extraocular muscles [0.03%]
成年狗和大鼠眼外肌的轨道纤维和全局纤维中复杂的原肌球蛋白和肌钙蛋白T异构体表达模式
Sabahattin Bicer,Peter J Reiser
Sabahattin Bicer
We reported marked differences in the myosin heavy and light chain (MHC and MLC) isoform composition of fast and slow fibers between the global and orbital layers of dog extraocular muscles. Many dog extraocular fibers, especially orbital f...
A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium [0.03%]
重组心肌中关于原肌球蛋白在心脏功能和疾病中的作用研究
Fan Bai,Li Wang,Masataka Kawai
Fan Bai
Tropomyosin (Tm) is the key regulatory component of the thin-filament and plays a central role in the cardiac muscle's cooperative activation mechanism. Many mutations of cardiac Tm are related to hypertrophic cardiomyopathy (HCM), dilated ...
Myofilament lattice structure in presence of a skeletal myopathy-related tropomyosin mutation [0.03%]
与骨骼肌病相关的原肌球蛋白突变下的肌节横截面排列结构改变
Julien Ochala,Hiroyuki Iwamoto
Julien Ochala
Human tropomyosin mutations deregulate skeletal muscle contraction at the cellular level. One key feature is the slowing of the kinetics of force development. The aim of the present study was to characterize the potential underlying molecul...
Gestalt-binding of tropomyosin on actin during thin filament activation [0.03%]
原肌球蛋白在细肌丝激活过程中的构象结合形式研究
William Lehman,Marek Orzechowski,Xiaochuan Edward Li et al.
William Lehman et al.
Our thesis is that thin filament function can only be fully understood and muscle regulation then elucidated if atomic structures of the thin filament are available to reveal the positions of tropomyosin on actin in all physiological states...
Impaired contractile responses and altered expression and phosphorylation of Ca(2+) sensitization proteins in gastric antrum smooth muscles from ob/ob mice [0.03%]
肥胖型(ob/ob)小鼠胃幽门平滑肌紧张性及收缩性的改变及热休克蛋白20表达和磷酸化水平的研究
Bhupal P Bhetwal,Changlong An,Salah A Baker et al.
Bhupal P Bhetwal et al.
Diabetic gastroparesis is a common complication of diabetes, adversely affecting quality of life with symptoms of abdominal discomfort, nausea, and vomiting. The pathogenesis of this complex disorder is not well understood, involving abnorm...
Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways [0.03%]
酪氨酸磷酸酶抑制剂Bpv(Hopic)通过激活PI3K/AKT和MAPK/ERK信号途径促进体外C2C12肌管迁移
Georgi A Dimchev,Nasser Al-Shanti,Claire E Stewart
Georgi A Dimchev
Muscle progenitor cell migration is an important step in skeletal muscle myogenesis and regeneration. Migration is required for muscle precursors to reach the site of damage and for the alignment of myoblasts prior to their fusion, which ul...
Myosin Mg-ATPase of molluscan muscles is slightly activated by F-actin under catch state in vitro [0.03%]
体外底栖动物肌肉肌球蛋白 Mg-ATP酶在捕获状态时略微被F-肌动蛋白激活
Akira Yamada,Maki Yoshio,Kazuhiro Oiwa
Akira Yamada
Molluscan muscle twitchin, a titin/connectin-related giant protein, regulates interactions between actin and myosin filaments at low Ca(2+) concentrations. When it is dephosphorylated, actin filaments tightly bind to myosin filaments, resul...
The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits magnesium binding to the C-domain of cardiac troponin C [0.03%]
绿茶儿茶素(-)-表棓儿茶素抑制镁与心肌原肌球蛋白调节轻链C区的结合
Franklin Fuchs,Zenon Grabarek
Franklin Fuchs
Cardiac muscle contraction is activated via the single Ca(2+)-binding site (site II) in the N-domain of troponin C (cTnC). The two Ca(2+)/Mg(2+) binding sites in the C-domain of cTnC (sites III and IV) have been considered to play a purely ...