Charles Redwood,Paul Robinson
Charles Redwood
The inherited cardiac diseases hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) can both be caused by missense mutations in the TPM1 gene which encodes the thin filament regulatory protein α-tropomyosin. Different mutatio...
Nuclear tropomyosin and troponin in striated muscle: new roles in a new locale? [0.03%]
核肌动蛋白和肌钙蛋白在横纹肌中的新作用？
P Bryant Chase,Mark P Szczypinski,Elliott P Soto
P Bryant Chase
Tropomyosin and troponin have well known Ca(2+)-regulatory functions in the striated muscle sarcomere. In this review, we summarize experimental evidence that tropomyosin and troponin are localized, with as yet unidentified functional roles...
Cytoskeletal tropomyosins: choreographers of actin filament functional diversity [0.03%]
细胞骨架肌动蛋白调控蛋白：编排肌动蛋白丝功能多样性的舞者
Howard Vindin,Peter Gunning
Howard Vindin
The actin cytoskeleton plays a central role in many essential cellular processes. Its involvement requires actin filaments to form multiple populations with different structural and therefore functional properties in specific subcellular lo...
In-depth proteomic analysis of human tropomyosin by top-down mass spectrometry [0.03%]
利用顶部质量测定法对人类原肌球蛋白进行深入的蛋白质组学分析
Ying Peng,Deyang Yu,Zachery Gregorich et al.
Ying Peng et al.
Tropomyosins (Tms) are a family of highly conserved actin-binding proteins that play critical roles in a variety of processes, most notably, in the regulation of muscle contraction and relaxation. It is well known that different Tm isoforms...
John M Squire
John M Squire
Miro Janco,Worawit Suphamungmee,Xiaochuan Li et al.
Miro Janco et al.
Tropomyosins (Tm) in humans are expressed from four distinct genes and by alternate splicing >40 different Tm polypeptide chains can be made. The functional Tm unit is a dimer of two parallel polypeptide chains and these can be assembled fr...
Mert Colpan,Natalia A Moroz,Alla S Kostyukova
Mert Colpan
Actin filaments are major components of the cytoskeleton in eukaryotic cells and are involved in vital cellular functions such as cell motility and muscle contraction. Tmod and TM are crucial constituents of the actin filament network, maki...
David H Heeley
David H Heeley
An historical perspective of the phosphorylation of tropomyosin is provided. The effects of this covalent modification on the properties of striated muscle tropomyosin are summarised. Technical hurdles and findings in other systems are also...
Emily M Schulz,David F Wieczorek
Emily M Schulz
The focus of this review is on the very recent work we have conducted that addresses the molecular, morphological, and physiological significance of cardiac tropomyosin phosphorylation in the heart. We employ transgenic mice to address ques...
Increased sarcolipin expression and decreased sarco(endo)plasmic reticulum Ca2+ uptake in skeletal muscles of mouse models of Duchenne muscular dystrophy [0.03%]
杜氏肌营养不良小鼠模型骨骼肌中sarcolipin表达增强和肌浆网Ca2+摄取能力降低
Joel S Schneider,Mayilvahanan Shanmugam,James Patrick Gonzalez et al.
Joel S Schneider et al.
Abnormal intracellular Ca(2+) handling is an important factor in the progressive functional decline of dystrophic muscle. In the present study, we investigated the function of sarco(endo)plasmic reticulum (SR) Ca(2+) ATPase (SERCA) in vario...