Three calpain isoforms are autolyzed in rat fast-twitch muscle after eccentric contractions [0.03%]
快速伸肌肌肉 eccentric 收缩后三种钙蛋白酶异构体的自水解
Keita Kanzaki,Mai Kuratani,Satoshi Matsunaga et al.
Keita Kanzaki et al.
The present study investigated changes in autolysis of three calpain isoforms in skeletal muscles undergoing eccentric contractions (ECC), leading to prolonged force deficits. Rat extensor digitorum longus and tibialis anterior muscles were...
Mohammed El-Mezgueldi
Mohammed El-Mezgueldi
Tropomyosin is a two chained α-helical coiled coil protein that binds actin filaments and interacts with various actin binding proteins. Tropomyosin function depends on its ability to move to distinct locations on the surface of actin in r...
Bert Blaauw,Carlo Reggiani
Bert Blaauw
The role of satellite cells in muscle hypertrophy has long been a debated issue. In the late 1980s it was shown that proteins remain close to the myonucleus responsible for its synthesis, giving rise to the idea of a nuclear domain. This, t...
Loop 2 of myosin is a force-dependent inhibitor of the rigor bond [0.03%]
肌球蛋白的环状结构域Ⅱ是调节横桥力依赖回旋的关键元件
Amy M Clobes,William H Guilford
Amy M Clobes
Myosin's actin-binding loop (loop 2) carries a charge opposite to that of its binding site on actin and is thought to play an important role in ionic interactions between the two molecules during the initial binding step. However, no subseq...
Muscle dysfunction in hypertrophic cardiomyopathy: what is needed to move to translation? [0.03%]
肥厚型心肌病的肌肉功能障碍：实现转化医学所需的内容是什么？
Corrado Poggesi,Carolyn Y Ho
Corrado Poggesi
Hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere genes. As such, HCM provides remarkable opportunities to study how changes to the heart's molecular motor apparatus may influence cardiac structure and function. Although...
Intrinsic cardiac adrenergic (ICA) cell density and MAO-A activity in failing rat hearts [0.03%]
心力衰竭大鼠心脏内在心脏肾上腺素能细胞密度和单胺氧化酶A活性的改变
Vincent W W van Eif,Sylvia J P Bogaards,Willem J van der Laarse
Vincent W W van Eif
The efficiency (work/oxygen consumption) of isolated papillary muscles from failing hearts is reduced. We investigated whether this can be due to an increase of intrinsic cardiac adrenergic (ICA) cell density. The number of ICA cells in the...
Avril Somlyo
Avril Somlyo
John Gergely (1919-2013): a pillar in the muscle protein field [0.03%]
约翰·杰勒吉（1919-2013）：肌丝蛋白研究领域的泰斗
Marion L Greaser,James D Potter,David D Thomas et al.
Marion L Greaser et al.
Dr. John Gergely passed away on July 26, 2013 after a long and distinguished career. His publications spanned 67 years. He founded the Department of Muscle Research in the Retina Foundation (which later became the Boston Biomedical Research...
Kenneth Holmes
Kenneth Holmes
Avril Somlyo
Avril Somlyo