A new mechanokinetic model for muscle contraction, where force and movement are triggered by phosphate release [0.03%]
一个新的肌动球蛋白机械动力学模型：磷酸释放引发力和运动
David A Smith
David A Smith
The atomic structure of myosin-S1 suggests that its working stroke, which generates tension and shortening in muscle, is triggered by the release of inorganic phosphate from the active site. This mechanism is the basis of a new mechanokinet...
Kinetics of cardiac myosin isoforms in mouse myocardium are affected differently by presence of myosin binding protein-C [0.03%]
心肌肌球蛋白结合蛋白-C对小鼠心脏各类型肌球蛋白动力学的不同影响
Bertrand C W Tanner,Yuan Wang,Jeffrey Robbins et al.
Bertrand C W Tanner et al.
We tested whether cardiac myosin binding protein-C (cMyBP-C) affects myosin cross-bridge kinetics in the two cardiac myosin heavy chain (MyHC) isoforms. Mice lacking cMyBP-C (t/t) and transgenic controls (WT(t/t)) were fed L-thyroxine (T4) ...
Tetanic Ca2+ transient differences between slow- and fast-twitch mouse skeletal muscle fibres: a comprehensive experimental approach [0.03%]
慢缩和快缩小鼠骨骼肌纤维的 tetanic Ca2+ 瞬变差异：一种全面的实验方法
Juan C Calderón,Pura Bolaños,Carlo Caputo
Juan C Calderón
One hundred and eighty six enzymatically dissociated murine muscle fibres were loaded with Mag-Fluo-4 AM, and adhered to laminin, to evaluate the effect of modulating cytosolic Ca(2+) buffers and sarcoendoplasmic reticulum Ca(2+) ATPase (SE...
The roles of troponin C isoforms in the mechanical function of Drosophila indirect flight muscle [0.03%]
节肢飞行肌肉中troponin C各异构体在机械功能中的作用
Catherine C Eldred,Anja Katzemich,Monica Patel et al.
Catherine C Eldred et al.
Stretch activation (SA) is a fundamental property of all muscle types that increases power output and efficiency, yet its mechanism is unknown. Recently, studies have implicated troponin isoforms as important in the SA mechanism. The highly...
Decrease in sarcoplasmic reticulum calcium content, not myofilament function, contributes to muscle twitch force decline in isolated cardiac trabeculae [0.03%]
孤立心脏心肌小梁中终池钙离子含量的降低而非肌丝功能导致了肌肉抽缩力的下降
Nima Milani-Nejad,Lucia Brunello,Sándor Gyorke et al.
Nima Milani-Nejad et al.
We set out to determine the factors responsible for twitch force decline in isolated intact rat cardiac trabeculae. The contractile force of trabeculae declined over extended periods of isometric twitch contractions. The force-frequency rel...
Chiao-Nan Joyce Chen,Ted G Graber,Wendy M Bratten et al.
Chiao-Nan Joyce Chen et al.
Increased proteasome activity has been implicated in the atrophy and deterioration associated with dystrophic muscles of Duchenne muscular dystrophy (DMD). While proteasome inhibitors show promise in the attenuation of muscle degeneration, ...
Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies [0.03%]
肌球蛋白C突变引起肥厚性心肌病和扩张型心肌病的生化特征分析
Athanasia Kalyva,Fragiskos I Parthenakis,Maria E Marketou et al.
Athanasia Kalyva et al.
Cardiac muscle contraction occurs through an interaction of the myosin head with the actin filaments, a process which is regulated by the troponin complex together with tropomyosin and is Ca(2+) dependent. Mutations in genes encoding sarcom...
The myosin-activated thin filament regulatory state, M⁻-open: a link to hypertrophic cardiomyopathy (HCM) [0.03%]
肌球蛋白激活的细丝调节状态M⁻-开放：与肥厚型心肌病(HCM)的关系
Sherwin S Lehrer,Michael A Geeves
Sherwin S Lehrer
This review proposes a link between the hypertrophic (HCM) and restrictive cardiomyopathies caused by mutations in several sarcomeric thin filament proteins, and the open state of the three-state muscle regulation theory. The three characte...
Coen A C Ottenheijm,Richard T Jaspers,Rob C I Wüst et al.
Coen A C Ottenheijm et al.
Oxidative stress in muscular dystrophy: from generic evidence to specific sources and targets [0.03%]
Duchenne肌营养不良症中的氧化应激：从泛在证据到具体来源和靶点
Marcella Canton,Sara Menazza,Fabio Di Lisa
Marcella Canton
Muscular dystrophies (MDs) are a heterogeneous group of diseases that share a common end-point represented by muscular wasting. MDs are caused by mutations in a variety of genes encoding for different molecules, including extracellular matr...