Extracellular stimulation with human "noisy" electromyographic patterns facilitates myotube activity [0.03%]
基于人体复杂的肌电图模式的外加电信号促进多核管状肌纤维生长和分化
M Sciancalepore,T Coslovich,P Lorenzon et al.
M Sciancalepore et al.
Electrical stimulation (ES) of skeletal muscle partially mimics the benefits of physical activity. However, the stimulation protocols applied clinically to date, often cause unpleasant symptoms and muscle fatigue. Here, we compared the effi...
Organization of junctional sarcoplasmic reticulum proteins in skeletal muscle fibers [0.03%]
骨骼肌纤维缝隙连接终池蛋白的组织方式
Virginia Barone,Davide Randazzo,Valeria Del Re et al.
Virginia Barone et al.
The sarcoplasmic reticulum (SR) of striated muscles is specialized for releasing Ca(2+) following sarcolemma depolarization in order to activate muscle contraction. To this end, the SR forms a network of longitudinal tubules and cisternae t...
Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin [0.03%]
静电相互作用图揭示了肌动蛋白纤维上肌节蛋白质的新结合位点
Michael J Rynkiewicz,Veronika Schott,Marek Orzechowski et al.
Michael J Rynkiewicz et al.
Azimuthal movement of tropomyosin around the F-actin thin filament is responsible for muscle activation and relaxation. Recently a model of αα-tropomyosin, derived from molecular-mechanics and electron microscopy of different contractile ...
Turnover of acetylcholine receptors at the endplate revisited: novel insights into nerve-dependent behavior [0.03%]
乙酰胆碱受体在终板的周转率：神经依赖行为的新见解
Siegfried Strack,Muzamil Majid Khan,Franziska Wild et al.
Siegfried Strack et al.
The turnover of nicotinic acetylcholine receptors (AChR) is a critical factor that determines function and safety of neuromuscular transmission at the nerve-muscle synapses, i.e. neuromuscular junctions (NMJs). Previously, three different p...
Chris Barclay,Nancy Curtin
Chris Barclay
A role for the Ca(2+)-dependent tyrosine kinase Pyk2 in tonic depolarization-induced vascular smooth muscle contraction [0.03%]
钙依赖性酪氨酸蛋白激酶Pyk2在血管平滑肌紧张性去极化收缩中的作用研究
Ryan D Mills,Mitsuo Mita,Michael P Walsh
Ryan D Mills
Depolarization of the plasma membrane is a key mechanism of activation of contraction of vascular smooth muscle. This is commonly achieved in isolated, de-endothelialized vascular smooth muscle strips by increasing extracellular [K(+)] (rep...
Zachary A Graham,Philip M Gallagher,Christopher P Cardozo
Zachary A Graham
Skeletal muscle has a remarkable ability to respond to different physical stresses. Loading muscle through exercise, either anaerobic or aerobic, can lead to increases in muscle size and function while, conversely, the absence of muscle loa...
C Snyman,C U Niesler
C Snyman
MMP-14 (also known as MT1-MMP) is a membrane-bound collagenase and member of the Matrix Metalloprotease (MMP) family known to target a broad range of extracellular matrix (ECM) proteins. Remodelling of the ECM is of particular importance fo...
Effects of fluvastatin and coenzyme Q10 on skeletal muscle in normo- and hypercholesterolaemic rats [0.03%]
氟伐他汀和辅酶Q10对正常和高胆固醇大鼠骨骼肌的影响
J Vincze,Á Jenes,M Füzi et al.
J Vincze et al.
Myalgia and muscle weakness may appreciably contribute to the poor adherence to statin therapy. Although the pathomechanism of statin-induced myopathy is not completely understood, changes in calcium homeostasis and reduced coenzyme Q10 lev...
High ionic strength depresses muscle contractility by decreasing both force per cross-bridge and the number of strongly attached cross-bridges [0.03%]
高离子强度通过减少每横桥张力和强相互作用横桥的数量来降低肌肉收缩能力
Li Wang,Anzel Bahadir,Masataka Kawai
Li Wang
An increase in ionic strength (IS) lowers Ca(2+) activated tension in muscle fibres, however, its molecular mechanism is not well understood. In this study, we used single rabbit psoas fibres to perform sinusoidal analyses. During Ca(2+) ac...