Progression of inflammation during immunodeficient mouse skeletal muscle regeneration [0.03%]
免疫缺陷型小鼠骨骼肌再生过程中的炎症演变动力学
Iwona Grabowska,Magdalena A Mazur,K Kowalski et al.
Iwona Grabowska et al.
The skeletal muscle injury triggers the inflammatory response which is crucial for damaged muscle fiber degradation and satellite cell activation. Immunodeficient mice are often used as a model to study the myogenic potential of transplante...
Reduced expression of MyHC slow isoform in rat soleus during unloading is accompanied by alterations of endogenous inhibitors of calcineurin/NFAT signaling pathway [0.03%]
低重力下大鼠比目肌慢肌纤维萎缩及其内源性抑制剂表达变化
Yulia N Lomonosova,Olga V Turtikova,Boris S Shenkman
Yulia N Lomonosova
Under muscle disuse conditions decrease of expression of MyHC of slow type, and sometimes of type IIa, as well as upregulation of expression of IIb and IId/x isoforms were observed. Through dephosphorylation and entry of NFAT molecules to t...
Sandra Furlan,Simone Mosole,Marta Murgia et al.
Sandra Furlan et al.
Calsequestrin (Casq) is a high capacity, low affinity Ca(2+)-binding protein, critical for Ca(2+)-buffering in cardiac and skeletal muscle sarcoplasmic reticulum. All vertebrates have multiple genes encoding for different Casq isoforms. Inc...
BAG3-related myopathy, polyneuropathy and cardiomyopathy with long QT syndrome [0.03%]
与BAG3相关的肌病、多发性神经病变和长QT综合征的心肌病
Anna Kostera-Pruszczyk,Małgorzata Suszek,Rafał Płoski et al.
Anna Kostera-Pruszczyk et al.
BAG3 belongs to BAG family of molecular chaperone regulators interacting with HSP70 and anti-apoptotic protein Bcl-2. It is ubiquitously expressed with strong expression in skeletal and cardiac muscle, and is involved in a panoply of cellul...
Repeated bouts of fast velocity eccentric contractions induce atrophy of gastrocnemius muscle in rats [0.03%]
快速离心收缩引起大鼠腓肠肌萎缩
Eisuke Ochi,Kazunori Nosaka,Arata Tsutaki et al.
Eisuke Ochi et al.
One bout of exercise consisting of fast velocity eccentric contractions has been shown to increase muscle protein degradation in rats. The present study tested the hypothesis that muscle atrophy would be induced after four bouts of fast vel...
Cyclic mechanical strain of myocytes modifies CapZβ1 post translationally via PKCε [0.03%]
周期性机械拉伸通过PKCε对肌细胞中的CapZβ1进行翻译后修饰
Ying-Hsi Lin,Erik R Swanson,Jieli Li et al.
Ying-Hsi Lin et al.
The heart is exquisitely sensitive to mechanical stimuli and adapts to increased demands for work by enlarging the cardiomyocytes. In order to determine links between mechano-transduction mechanisms and hypertrophy, neonatal rat ventricular...
Nucleotide and protein sequences for dog masticatory tropomyosin identify a novel Tpm4 gene product [0.03%]
犬咀嚼肌原肌球蛋白的核苷酸和氨基酸序列鉴定出一个新的Tpm4基因产物
Elizabeth A Brundage,Brandon J Biesiadecki,Peter J Reiser
Elizabeth A Brundage
Jaw-closing muscles of several vertebrate species, including members of Carnivora, express a unique, "masticatory", isoform of myosin heavy chain, along with isoforms of other myofibrillar proteins that are not expressed in most other muscl...
Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations [0.03%]
与肌球蛋白轻链突变相关的心肌病表型的分子机制
Wenrui Huang,Danuta Szczesna-Cordary
Wenrui Huang
We discuss here the potential mechanisms of action associated with hypertrophic (HCM) or dilated (DCM) cardiomyopathy causing mutations in the myosin regulatory (RLC) and essential (ELC) light chains. Specifically, we focus on four HCM muta...
Phosphoinositides in Ca(2+) signaling and excitation-contraction coupling in skeletal muscle: an old player and newcomers [0.03%]
磷脂肌醇在骨骼肌钙信号及兴奋收缩偶联中的作用：一位老将和几位新秀
Laszlo Csernoch,Vincent Jacquemond
Laszlo Csernoch
Since the postulate, 30 years ago, that phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P 2) as the precursor of inositol 1,4,5-trisphosphate (Ins(1,4,5)P 3) would be critical for skeletal muscle excitation-contraction (EC) coupling, the ...