The elementary step that generates force and sinusoidal analysis in striated muscle fibers [0.03%]
横纹肌纤维产生力的原初步骤和正弦分析
Masataka Kawai
Masataka Kawai
The elementary step that generates force by cross-bridges (CBs) in striated muscles is reviewed. A literature search focused on models with validating data to verify a CB scheme; models without substantiating data were briefly mentioned or ...
The impact of mitokine MOTS-c administration on the soleus muscle of rats subjected to a 7-day hindlimb suspension [0.03%]
线粒体因子MOTS-c对模拟微重力环境下大鼠腓肠肌的影响研究
Daria A Sidorenko,Irina D Lvova,Sergey A Tyganov et al.
Daria A Sidorenko et al.
The aim of the study was to investigate the effect of MOTS-c on the key functional alterations in the rat soleus muscle during 7-day unloading - the transformation of slow fibers into fast ones, atrophy and increased fatigue. We daily intra...
Terence Partridge
Terence Partridge
A brief discussion about skeletal muscle, aberrant expression of dystrophin from null mutations of the gene, potential explanations as to why this occurs, and how understanding this could be useful for potential therapies in the future. ...
Insights into human muscle biology from human primary skeletal muscle cell culture [0.03%]
人原代骨骼肌细胞培养的人肌肉生物学启示
Thomas Francis,Casper Soendenbroe,Norman R Lazarus et al.
Thomas Francis et al.
This review arises from the symposium held in honour of Prof Jenny Morgan at UCL in 2024 and the authors would like to acknowledge the outstanding contribution that Prof Morgan has made to the field of translational muscle cell biology. Pro...
RNA-seq and ChIP-seq unveils thyroid hormone receptor α deficiency affects skeletal muscle myoblast proliferation and differentiation via Col6a1 during aging [0.03%]
RNA测序和ChIP测序揭示甲状腺激素受体α缺乏通过胶原蛋白6a1影响衰老期间骨骼肌前体细胞的增殖和分化
Runqing Shi,Gong Chen,Yusheng Zhang et al.
Runqing Shi et al.
Primary sarcopenia, an age-related syndrome, is a serious threat to the health and longevity of the elderly. Our prior studies indicated that thyroid hormone (TH) activity within muscle tissue undergoes significant age-associated alteration...
Shuang Li,Jin Xu,Wenjia Zhang et al.
Shuang Li et al.
Rho guanine nucleotide exchange factor 9 (ARHGEF9), as a protein that assists small GTPases, is widely present in various tissues. It has been reported to play an important role mainly in neurological diseases and gliomas. However, there ha...
C Villella,M Ciccioli,I M Anton et al.
C Villella et al.
Under normal physiological conditions, leukocytes and other tissue resident immune cells have been shown to migrate using the mesenchymal (integrin/adhesion dependent) and/or ameboid (integrin/adhesion independent) modes of migration. The o...
Differential impact of substrates on myosin heavy and light chain expression in human stem cell-derived cardiomyocytes at single-cell level [0.03%]
底物对单细胞水平人干细胞衍生的心肌细胞肌球蛋白重链和轻链表达的差异影响
Felix Osten,Alea K Bodenschatz,Karina Ivaskevica et al.
Felix Osten et al.
To fully exploit the potential of human pluripotent stem cell-derived cardiomyocytes, ideally they should acquire a mature, adult ventricular-like phenotype. Predominant expression of the β-isoform of myosin heavy chain (β-MyHC) and the v...
Fluorescence lifetime imaging microscopy of endogenous fluorophores in health and disease [0.03%]
健康与疾病状态下自发荧光分子的荧光寿命成像显微scopy研究
Barbara Elsnicova
Barbara Elsnicova
Fluorescence Lifetime Imaging Microscopy (FLIM) of endogenous fluorophores has recently emerged as a powerful, marker-free, and non-invasive tool for investigating cellular metabolism. This cutting-edge imaging technique provides valuable i...
Progress and prospects in antisense oligonucleotide-mediated exon skipping therapies for Duchenne muscular dystrophy [0.03%]
反义寡核苷酸介导的外显子跳跃疗法治疗杜氏肌营养不良症的研究进展与前景
Katarzyna Chwalenia,Matthew J A Wood,Thomas C Roberts
Katarzyna Chwalenia
Recent years have seen enormous progress in the field of advanced therapeutics for the progressive muscle wasting disease Duchenne muscular dystrophy (DMD). In particular, four antisense oligonucleotide (ASO) therapies targeting various DMD...