Degenerative and regenerative features of myofibers differ among skeletal muscles in a murine model of muscular dystrophy [0.03%]
杜氏肌营养不良小鼠模型中骨骼肌的退行性和再生性特征各不相同
Teppei Ikeda,Osamu Ichii,Saori Otsuka-Kanazawa et al.
Teppei Ikeda et al.
Skeletal muscle myofibers constantly undergo degeneration and regeneration. Histopathological features of 6 skeletal muscles (cranial tibial [CT], gastrocnemius, quadriceps femoris, triceps brachii [TB], lumbar longissimus muscles, and cost...
Muscle fiber types composition and type identified endplate morphology of forepaw intrinsic muscles in the rat [0.03%]
大鼠前肢固有肌的肌纤维类型组成和类型的终板形态学特征
Feng Pan,Jing-Yi Mi,Yan Zhang et al.
Feng Pan et al.
The failure to accept reinnervation is considered to be one of the reasons for the poor motor functional recovery of intrinsic hand muscles (IHMs) after nerve injury. Rat could be a suitable model to be used in simulating motor function rec...
Exome sequencing identifies variants in two genes encoding the LIM-proteins NRAP and FHL1 in an Italian patient with BAG3 myofibrillar myopathy [0.03%]
外显子组测序鉴定到两个编码LIM蛋白（肢带肌营养不良样蛋白和角质细胞分化相关蛋白1）的基因中的变异：NRAP和FHL1在BAG3型肌原纤维肌病意大利患者中研究
Francesca D&#x;Avila,Mirella Meregalli,Sara Lupoli et al.
Francesca D&#x;Avila et al.
Myofibrillar myopathies (MFMs) are genetically heterogeneous dystrophies characterized by the disintegration of Z-disks and myofibrils and are associated with mutations in genes encoding Z-disk or Z-disk-related proteins. The c.626 C > T (p...
Johann Caspar Rüegg
Johann Caspar Rüegg
Wilhelm Hasselbach (1921-2015) is best known for his major contribution to the discovery and molecular elucidation of an ATP-driven active ion transport across a biological membrane. He had discovered SERCA, the calcium pump of the sarcopla...
Interplay between the effects of a Protein Kinase C phosphomimic (T204E) and a dilated cardiomyopathy mutation (K211Δ or R206W) in rat cardiac troponin T blunts the magnitude of muscle length-mediated crossbridge recruitment against the β-myosin heavy chain background [0.03%]
PKC磷基类似物(T204E)和扩张型心肌病突变(K211Δ或R206W)在大鼠心脏troponin T中的相互作用会减弱β-肌球蛋白重链背景下的肌肉长度介导的横桥募集量
John Jeshurun Michael,Sampath K Gollapudi,Murali Chandra
John Jeshurun Michael
Failing hearts of dilated cardiomyopathy (DCM)-patients reveal systolic dysfunction and upregulation of several Protein Kinase C (PKC) isoforms. Recently, we demonstrated that the functional effects of T204E, a PKC phosphomimic of cardiac t...
Investigating the effects of tropomyosin mutations on its flexibility and interactions with filamentous actin using molecular dynamics simulation [0.03%]
利用分子动力学模拟研究肌动蛋白突变对原肌球蛋白柔韧性及与肌动蛋白丝相互作用的影响
Wenjun Zheng,Sarah E Hitchcock-DeGregori,Bipasha Barua
Wenjun Zheng
Tropomyosin (Tpm) is a two-chained α-helical coiled-coil protein that binds to filamentous actin (F-actin), and regulates its interactions with myosin by occupying three average positions on F-actin (blocked, closed, and open). Mutations i...
Excitation contraction uncoupling by high intracellular [Ca2+] in frog skeletal muscle: a voltage clamp study [0.03%]
高细胞内钙离子引起的蛙骨骼肌兴奋收缩脱耦合：电压钳研究
J Fernando Olivera,Gonzalo Pizarro
J Fernando Olivera
Raising the intracellular [Ca2+] ([Ca2+]i) was previously found to produce uncoupling between the electrical depolarization of the transverse tubules and contraction in skinned muscle fibers. Here we study the effect of elevated [Ca2+]i in ...
Cloning, molecular characterization, and expression analysis of the unc45 myosin chaperone b(unc45b)gene of grass carp (Ctenopharyngodon idellus) [0.03%]
草鱼Unc45b基因的克隆、分子特性分析及表达研究
Jing Hu,Ting Guo,Wen-Qian Pan et al.
Jing Hu et al.
Unc45 myosin chaperone b(unc45b)gene is a molecular chaperone that mediates the folding, assembly and accumulation of thick-filament myosin in the formation of sarcomere, which plays an important role in the development of striated muscle a...
Sarcoplasmic reticulum is an intermediary of mitochondrial and myofibrillar growth at the intercalated disc [0.03%]
肌浆网是肌节中间盘区线粒体和肌丝生长的中介体
Pauline M Bennett,Elisabeth Ehler,Amanda J Wilson
Pauline M Bennett
In cardiomyocytes columns of intermyofibrillar mitochondria run up to the intercalated disc (ID); half are collinear with those in the neighbouring cell, suggesting coordinated addition of sarcomeres and mitochondria both within and between...
Comprehensive analysis of tropomyosin isoforms in skeletal muscles by top-down proteomics [0.03%]
基于顶端蛋白质组学的骨骼肌Troponin T同种型全面分析研究
Yutong Jin,Ying Peng,Ziqing Lin et al.
Yutong Jin et al.
Mammalian skeletal muscles are heterogeneous in nature and are capable of performing various functions. Tropomyosin (Tpm) is a major component of the thin filament in skeletal muscles and plays an important role in controlling muscle contra...