The TRPM4 channel is functionally important for the beneficial cardiac remodeling induced by endurance training [0.03%]
端urance训练诱导的心脏有益重塑功能需要TRPM4通道
Mélanie Gueffier,Justin Zintz,Karen Lambert et al.
Mélanie Gueffier et al.
Cardiac hypertrophy (CH) is an adaptive process that exists in two distinct forms and allows the heart to adequately respond to an organism's needs. The first form of CH is physiological, adaptive and reversible. The second is pathological,...
Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only [0.03%]
钙调蛋白2(CASQ2)基因敲除鼠快肌和慢肌的特征：仅快肌出现非预期的适应性变化
Giorgia Valle,Barbara Vergani,Roberta Sacchetto et al.
Giorgia Valle et al.
This study investigates the functional role of calsequestrin 2 (CASQ2) in both fast-twitch and slow-twitch skeletal muscles by using CASQ2-/- mice; CASQ2 is expressed throughout life in slow-twitch muscles, but only in the developmental and...
Michelle L Munro,Christian Soeller
Michelle L Munro
The ventricular cardiomyocytes of adult mammals contain invaginations of the plasma membrane known as transverse (t)-tubules. These regular structures are essential for the synchronisation of excitation-contraction (EC) coupling throughout ...
L71F mutation in rat cardiac troponin T augments crossbridge recruitment and detachment dynamics against α-myosin heavy chain, but not against β-myosin heavy chain [0.03%]
大鼠心脏肌钙蛋白T L71F突变增强横桥募集和脱落动力学对抗α-肌球蛋白重链，但不抗β-肌球蛋白重链
Sherif M Reda,Sampath K Gollapudi,Murali Chandra
Sherif M Reda
The N-terminal extension of human cardiac troponin T (TnT), which modulates myofilament Ca2+ sensitivity, contains several hypertrophic cardiomyopathy (HCM)-causing mutations including S69F. However, the functional consequence of S69F mutat...
Comparison of elementary steps of the cross-bridge cycle in rat papillary muscle fibers expressing α- and β-myosin heavy chain with sinusoidal analysis [0.03%]
正弦分析法研究表达α-MHC和β-MHC大鼠乳头肌纤维交叉桥周期的基本过程的比较
Masataka Kawai,Tarek S Karam,John Jeshurun Michael et al.
Masataka Kawai et al.
In mammalian ventricles, two myosin heavy chain (MHC) isoforms have been identified. Small animals express α-MHC, whereas large animals express β-MHC, which contribute to a large difference in the heart rate. Sprague-Dawley rats possessin...
Cardioprotective effects of omega 3 fatty acids: origin of the variability [0.03%]
ω-3脂肪酸的心脏保护作用：变异性来源分析
Jérôme Roy,Jean-Yves Le Guennec
Jérôme Roy
Since 40 years, it is known that omega-3 poly-unsaturated fatty acids (ω3 PUFAs) have cardioprotective effects. These include antiarrhythmic effects, improvements of autonomic function, endothelial function, platelet anti-aggregation and i...
Actomyosin based contraction: one mechanokinetic model from single molecules to muscle? [0.03%]
以肌动蛋白为基础的收缩：从单一分子到肌肉的一个力学-动力学模型？
Alf Månsson
Alf Månsson
Bridging the gaps between experimental systems on different hierarchical scales is needed to overcome remaining challenges in the understanding of muscle contraction. Here, a mathematical model with well-characterized structural and biochem...
Differential effects of contractile potentiators on action potential-induced Ca2+ transients of frog and mouse skeletal muscle fibres [0.03%]
收缩增强剂对蛙和小鼠骨骼肌纤维的动作电位诱导的钙瞬变的不同影响
Caputo Carlo,Bolaños Pura,Ramos Magaly et al.
Caputo Carlo et al.
Muscle fibres, isolated from frog tibialis anterior and mouse flexor digitorum brevis (FDB) were loaded with the fast dye MagFluo-4 to study the effects of potentiators caffeine, nitrate, Zn2+ and perchlorate on Ca2+ transients elicited by ...
Pasquale Bianco,Massimo Reconditi,Gabriella Piazzesi et al.
Pasquale Bianco et al.