Physiology and pathophysiology of excitation-contraction coupling: the functional role of ryanodine receptor [0.03%]
钙诱导钙释放介导兴奋收缩耦联的生理及病理生理功能研究
Gaetano Santulli,Daniel R Lewis,Andrew R Marks
Gaetano Santulli
Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in sk...
Follistatin treatment suppresses SERCA1b levels independently of other players of calcium homeostasis in C2C12 myotubes [0.03%]
抗肌萎缩蛋白转基因小鼠肌肉细胞中抑肌肽治疗抑制SERCA1b水平独立于钙稳态的其他参与者在C2C12肌管
János Fodor,Adrienn Gomba-Tóth,Tamás Oláh et al.
János Fodor et al.
Follistatin (FS) is a high affinity activin-binding protein, neutralizing the effects of the Transforming Growth Factor-beta (TGF-β) superfamily members, as myostatin (MSTN). Since MSTN emerged as a negative regulator, FS has been consider...
Acute high-caffeine exposure increases autophagic flux and reduces protein synthesis in C2C12 skeletal myotubes [0.03%]
急性高咖啡因暴露增加C2C12骨骼肌管的自噬流量并降低蛋白质合成
M A Hughes,R M Downs,G W Webb et al.
M A Hughes et al.
Caffeine is a highly catabolic dietary stimulant. High caffeine concentrations (1-10 mM) have previously been shown to inhibit protein synthesis and increase protein degradation in various mammalian cell lines. The purpose of this study was...
Cooperativity of myosin interaction with thin filaments is enhanced by stabilizing substitutions in tropomyosin [0.03%]
稳定变体肌浆球蛋白与细丝相互作用的协同性增强
Daniil V Shchepkin,Salavat R Nabiev,Galina V Kopylova et al.
Daniil V Shchepkin et al.
Muscle contraction is powered by myosin interaction with actin-based thin filaments containing Ca2+-regulatory proteins, tropomyosin and troponin. Coiled-coil tropomyosin molecules form a long helical strand that winds around actin filament...
Marked decrease of aquaporin-4 protein is independent of the changes in α1-syntrophin and TRPV4 levels in response to denervation-induced muscle atrophy in vivo [0.03%]
脱神经肌肉萎缩时水通道蛋白4的改变独立于α1- syntrophin和TRPV4的变化
Minenori Ishido,Tomohiro Nakamura
Minenori Ishido
Aquaporin-4 (AQP4) is a selective water channel mediating water transport across cell membranes in skeletal muscles. Recently, it was noted that AQP4 is one of the key molecules regulating muscle morphology. Indeed, the AQP4 accumulation le...
Esther Barreiro,Shahragim Tajbakhsh
Esther Barreiro
In eukaryote cells, chromatin appears in several forms and is composed of genomic DNA, protein and RNA. The protein content of chromatin is composed primarily of core histones that are packaged into nucleosomes resulting in the condensation...
C J Barclay
C J Barclay
The energy required for muscle contraction is provided by the breakdown of ATP but the amount of ATP in muscles cells is sufficient to power only a short duration of contraction. Buffering of ATP by phosphocreatine, a reaction catalysed by ...
Mouse soleus (slow) muscle shows greater intramyocellular lipid droplet accumulation than EDL (fast) muscle: fiber type-specific analysis [0.03%]
慢缩的鼠腓肠肌比快缩的鼠伸趾长屈肌表现出更多的细胞内脂滴蓄积：肌纤维类型特异性分析
Yusuke Komiya,Shoko Sawano,Daisuke Mashima et al.
Yusuke Komiya et al.
Skeletal muscle is the main tissue of lipid metabolism and accordingly is critical for homeostasis and energy production; however, the determinants of lipid accumulation in skeletal muscle are unknown. Here, we examined whether the soleus m...
Respiratory muscle contractile inactivity induced by mechanical ventilation in piglets leads to leaky ryanodine receptors and diaphragm weakness [0.03%]
机械通气引起的猪letype="sup">letype="sup">letype="sup">letype="sup">letype="sup">呼吸肌收缩不全导致ryanodine受体渗漏和膈肌无力
Stefan Matecki,Boris Jung,Nathalie Saint et al.
Stefan Matecki et al.
Respiratory muscle contractile inactivity during mechanical ventilation (MV) induces diaphragm muscle weakness, a condition referred to as ventilator-induced diaphragmatic dysfunction (VIDD). Although VIDD pathophysiological mechanisms are ...
Shortening speed dependent force potentiation is attenuated but not eliminated in skeletal muscles without myosin phosphorylation [0.03%]
肌球蛋白磷酸化缺失的骨骼肌中与缩短速度相关的力增强作用减弱但并未消失
William Gittings,Jordan Bunda,Rene Vandenboom
William Gittings
We investigated the influence of shortening speed on concentric force potentiation at different frequencies in muscles devoid of skeletal myosin light chain kinase (skMLCK-/-) and unable to phosphorylate myosin. EDL muscles from skMLCK-/- m...