Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy [0.03%]
原发性MYH7表达调节对肥厚型心肌病的组织等位基因失衡有贡献
Judith Montag,Mandy Syring,Julia Rose et al.
Judith Montag et al.
HCM, the most common inherited cardiac disease, is mainly caused by mutations in sarcomeric genes. More than a third of the patients are heterozygous for mutations in the MYH7 gene encoding for the β-myosin heavy chain. In HCM-patients, ex...
Anisotropic mechanosensitive pathways in the diaphragm and their implications in muscular dystrophies [0.03%]
膈肌中各向异性的机械敏感通路及其在肌肉营养不良中的影响
Patricia S Pardo,Michael A Lopez,Junaith S Mohamed et al.
Patricia S Pardo et al.
The diaphragm is the "respiratory pump;" the muscle that generates pressure to allow ventilation. Diaphragm muscles play a vital function and thus are subjected to continuous mechanical loading. One of its peculiarities is the ability to ge...
Kinetic coupling of phosphate release, force generation and rate-limiting steps in the cross-bridge cycle [0.03%]
磷酸释放、力产生及交联桥周期中限速步骤的动力学偶联关系
Robert Stehle,Chiara Tesi
Robert Stehle
A basic goal in muscle research is to understand how the cyclic ATPase activity of cross-bridges is converted into mechanical force. A direct approach to study the chemo-mechanical coupling between Pi release and the force-generating step i...
Spot light on skeletal muscles: optogenetic stimulation to understand and restore skeletal muscle function [0.03%]
骨骼肌的光遗传学刺激：从理解到修复功能
Tobias van Bremen,Thorsten Send,Philipp Sasse et al.
Tobias van Bremen et al.
Damage of peripheral nerves results in paralysis of skeletal muscle. Currently, the only treatment option to restore proper function is electrical stimulation of the innervating nerve or of the skeletal muscles directly. However this approa...
Are there two different binding sites for ATP on the myosin head, or only one that switches between two conformers? [0.03%]
肌球蛋白头部存在两个不同的ATP结合位点吗，还是只有一个在两种构象之间转换的位点？
Chiara Tesi,Tom Barman,Corinne Lionne
Chiara Tesi
Insight into muscle physiology through understanding mechanisms of muscle pathology [0.03%]
通过了解肌肉病理机制来洞察肌肉生理学
Olivier Cazorla,Stefan Matecki
Olivier Cazorla
Proteomic profiling of the dystrophin complex and membrane fraction from dystrophic mdx muscle reveals decreases in the cytolinker desmoglein and increases in the extracellular matrix stabilizers biglycan and fibronectin [0.03%]
蛋白组学分析 Duchenne 肌营养不良小鼠肌肉中的dystrophin复合体和膜组分发现胞内连接蛋白脱细胞粘附分子(desmoglein)减少，而细胞外基质稳定因子大乳酸蛋白(biglycan)和纤维连结蛋白增加
Sandra Murphy,Heinrich Brinkmeier,Mirjam Krautwald et al.
Sandra Murphy et al.
The almost complete loss of the membrane cytoskeletal protein dystrophin and concomitant drastic reduction in dystrophin-associated glycoproteins are the underlying mechanisms of the highly progressive neuromuscular disorder Duchenne muscul...
Mara Rusu,Zhongjun Hu,Kenneth A Taylor et al.
Mara Rusu et al.
The Z-disk is a complex structure comprising some 40 proteins that are involved in the transmission of force developed during muscle contraction and in important signalling pathways that govern muscle homeostasis. In the Z-disk the ends of ...
Lanette Fee,Weili Lin,Feng Qiu et al.
Lanette Fee et al.
We present the genomic and expressed myosin II sequences from the giant waterbug, Lethocerus indicus. The intron rich gene appears relatively ancient and contains six regions of mutually exclusive exons that are alternatively spliced. Alter...
The Secretory Leukocyte Protease Inhibitor mRNA expression is involved with inflammatory control after downhill exercise in the triceps brachii intermediary head in Wistar rats [0.03%]
Wistar大鼠负斜坡运动后三头肌中间头分泌型白细胞蛋白酶抑制剂mRNA表达的炎症调控作用研究
André Luis Araujo Minari,Lila Missae Oyama,Ronaldo Vagner Thomatieli Dos Santos
André Luis Araujo Minari
After severe skeletal muscle damage, communication between inflammatory macrophages, myogenic cells, and modulatory secretion factors is essential to induce re-establishment of skeletal muscle structure. To analyze when characteristic gene ...